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学科主题: 临床医学
题名:
Overexpression of ROCK1 and ROCK2 inhibits human laryngeal squamous cell carcinoma
作者: Zhang, Junbo1; He, Xue2; Ma, Yueying4; Liu, Yanli2; Shi, Huaiyin3; Guo, Weiwei2; Liu, Liangfa4
关键词: Laryngeal squamous cell carcinoma ; ROCK ; Y-27632 ; tumor growth ; lymph node metastasis
刊名: INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY
发表日期: 2015
卷: 8, 期:1, 页:244-251
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology ; Pathology
研究领域[WOS]: Oncology ; Pathology
关键词[WOS]: RHO-KINASE ; IN-VIVO ; RHO/ROCK PATHWAY ; CANCER CELLS ; INVASION ; TUMOR ; METASTASIS ; EXPRESSION ; MIGRATION ; PROTEIN
英文摘要:

Rho-associated coiled-coil containing protein kinase (ROCK) over-expression has been implicated in the progression of many tumor types. The aim of this study was to explore the roles of ROCK1 and ROCK2 in human laryngeal squamous cell carcinoma (LSCC). ROCK1 and ROCK2 expression levels were examined in 50 cases of human LSCC samples by immunohistochemistry. Effects of ROCK1 and ROCK2 on LSCC cell proliferation and motility were investigated in the presence of the ROCK inhibitor Y-27632. The results showed that ROCK1 expression was positively correlated with tumor size and lymph node metastasis (P < 0.05); ROCK2 positively correlated with tumor size (P < 0.05). Inhibition of ROCK1 and ROCK2 by Y-27632 significantly inhibits proliferation, migration, and invasion of LSCC cells. Our data indicate that expression of ROCK1 and ROCK2 are closely associated with tumor growth and lymph node metastasis of LSCC. Thus, these two ROCK isoforms may be useful as molecular makers for LSCC diagnosis and may be useful therapeutic targets as well.

语种: 英语
WOS记录号: WOS:000349838700024
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50424
Appears in Collections:北京大学第一临床医学院_期刊论文

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作者单位: 1.Peking Univ, Hosp 1, Dept Otolaryngol Head & Neck Surg, Beijing 100034, Peoples R China
2.Chinese Peoples Liberat Army Gen Hosp, Dept Otolaryngol Head & Neck Surg, Beijing 100853, Peoples R China
3.Chinese Peoples Liberat Army Gen Hosp, Dept Pathol, Beijing 100853, Peoples R China
4.Capital Med Univ, Beijing Friendship Hosp, Dept Otolaryngol Head & Neck Surg, Beijing 100050, Peoples R China

Recommended Citation:
Zhang, Junbo,He, Xue,Ma, Yueying,et al. Overexpression of ROCK1 and ROCK2 inhibits human laryngeal squamous cell carcinoma[J]. INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY,2015,8(1):244-251.
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