IR@PKUHSC  > 北京大学第一临床医学院
学科主题临床医学
Overexpression of ROCK1 and ROCK2 inhibits human laryngeal squamous cell carcinoma
Zhang, Junbo1; He, Xue2; Ma, Yueying4; Liu, Yanli2; Shi, Huaiyin3; Guo, Weiwei2; Liu, Liangfa4
关键词Laryngeal Squamous Cell Carcinoma Rock Y-27632 Tumor Growth Lymph Node Metastasis
刊名INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY
2015
8期:1页:244-251
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology ; Pathology
研究领域[WOS]Oncology ; Pathology
关键词[WOS]RHO-KINASE ; IN-VIVO ; RHO/ROCK PATHWAY ; CANCER CELLS ; INVASION ; TUMOR ; METASTASIS ; EXPRESSION ; MIGRATION ; PROTEIN
英文摘要

Rho-associated coiled-coil containing protein kinase (ROCK) over-expression has been implicated in the progression of many tumor types. The aim of this study was to explore the roles of ROCK1 and ROCK2 in human laryngeal squamous cell carcinoma (LSCC). ROCK1 and ROCK2 expression levels were examined in 50 cases of human LSCC samples by immunohistochemistry. Effects of ROCK1 and ROCK2 on LSCC cell proliferation and motility were investigated in the presence of the ROCK inhibitor Y-27632. The results showed that ROCK1 expression was positively correlated with tumor size and lymph node metastasis (P < 0.05); ROCK2 positively correlated with tumor size (P < 0.05). Inhibition of ROCK1 and ROCK2 by Y-27632 significantly inhibits proliferation, migration, and invasion of LSCC cells. Our data indicate that expression of ROCK1 and ROCK2 are closely associated with tumor growth and lymph node metastasis of LSCC. Thus, these two ROCK isoforms may be useful as molecular makers for LSCC diagnosis and may be useful therapeutic targets as well.

语种英语
WOS记录号WOS:000349838700024
引用统计
被引频次:10[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50424
专题北京大学第一临床医学院
作者单位1.Peking Univ, Hosp 1, Dept Otolaryngol Head & Neck Surg, Beijing 100034, Peoples R China
2.Chinese Peoples Liberat Army Gen Hosp, Dept Otolaryngol Head & Neck Surg, Beijing 100853, Peoples R China
3.Chinese Peoples Liberat Army Gen Hosp, Dept Pathol, Beijing 100853, Peoples R China
4.Capital Med Univ, Beijing Friendship Hosp, Dept Otolaryngol Head & Neck Surg, Beijing 100050, Peoples R China
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GB/T 7714
Zhang, Junbo,He, Xue,Ma, Yueying,et al. Overexpression of ROCK1 and ROCK2 inhibits human laryngeal squamous cell carcinoma[J]. INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY,2015,8(1):244-251.
APA Zhang, Junbo.,He, Xue.,Ma, Yueying.,Liu, Yanli.,Shi, Huaiyin.,...&Liu, Liangfa.(2015).Overexpression of ROCK1 and ROCK2 inhibits human laryngeal squamous cell carcinoma.INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY,8(1),244-251.
MLA Zhang, Junbo,et al."Overexpression of ROCK1 and ROCK2 inhibits human laryngeal squamous cell carcinoma".INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY 8.1(2015):244-251.
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