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The role of muscarinic acetylcholine receptor type 3 polypeptide (M3RP(205-220)) antibody in the saliva of patients with primary Sjogren′s syndrome
He, J.1; Qiang, L.2,3; Ding, Y.1; Wei, P.2,3; Li, Y. -N.1; Hua, H.2,3; Li, Z. -G.1
关键词Primary Sjogren&Prime s Syndrome Saliva Type 3 Muscarinic Acetylcholine Receptor
刊名CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
2012-05-01
30期:3页:322-326
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Rheumatology
研究领域[WOS]Rheumatology
关键词[WOS]REVISED CRITERIA ; AUTOANTIBODIES ; CLASSIFICATION
英文摘要

Background

Sjogren′s syndrome (SS) is a chronic autoimmune disorder of unknown cause. Recent studies have shown that anti-muscarinic acetylcholine type 3 receptor (M3R) antibodies can be detected in patients with Sjogren′s syndrome (SS), but little is known about the diagnostic value of this antibody.

Objective

To assess the clinical correlations of anti-M3R (muscarinic acetylcholine receptor type 3) polypeptide (M3RP(205-220)) antibodies in saliva from patients of primary Sjogren′s syndrome (pSS).

Methods

Serum samples and unstimulated mixed saliva from 100 patients with SS were collected and examined. Their mean (SD) age was 54.2 (13.4) years, and the mean (SD) disease duration was 6.2 (3.8) years. Serum samples from 40 patients with systemic lupus erythematosus (SLE), 40 with rheumatoid arthritis (RA), and 60 healthy subjects were analysed as controls. All the patients with SS were carefully evaluated according to European and American criteria. A circular M3RP(205-220) peptide sequence was synthesized using solid-phase techniques on an applied biosytems peptide synthesizer. The correlation between anti-M3RP(205-220) antibodies and clinical manifestations of pSS was analysed.

Results

The IgG of anti-M3RP(205-220) antibodies was present in 69% of patients with pSS, 27.5% with SLE, 22.5% with RA, and 23.3% of normal saliva donors. The prevalence of anti-M3RP(205-220) antibodies in pSS was significantly higher than in SLE, RA, and normal controls. The specificity of anti-M3RP(205-220) antibodies in pSS was 75%. The salivary flow rate in the group positive for anti-M3RP(205-220) was 436 mu l/10 min, compared to a rate of 658 mu l/10 min for the negative group (p<0.05).

Conclusion

The anti-M3RP(205-220) antibody was detected in most patients with pSS. The presence of the antibody was closely associated with the salivary flow rate. This indicated that it may act as an autoantigen, with a role in the pathogenesis of pSS.

语种英语
WOS记录号WOS:000306380100002
引用统计
被引频次:16[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50428
专题北京大学第二临床医学院
北京大学口腔医学院_口腔黏膜科
北京大学临床肿瘤学院_药剂科
作者单位1.Peking Univ, Peoples Hosp, Dept Rheumatol & Immunol, Beijing 100044, Peoples R China
2.Peking Univ, Dept Oral Med, Sch Stomatol, Beijing 100081, Peoples R China
3.Peking Univ, Dept Oral Med, Hosp Stomatol, Beijing 100081, Peoples R China
推荐引用方式
GB/T 7714
He, J.,Qiang, L.,Ding, Y.,et al. The role of muscarinic acetylcholine receptor type 3 polypeptide (M3RP(205-220)) antibody in the saliva of patients with primary Sjogren&prime;s syndrome[J]. CLINICAL AND EXPERIMENTAL RHEUMATOLOGY,2012,30(3):322-326.
APA He, J..,Qiang, L..,Ding, Y..,Wei, P..,Li, Y. -N..,...&Li, Z. -G..(2012).The role of muscarinic acetylcholine receptor type 3 polypeptide (M3RP(205-220)) antibody in the saliva of patients with primary Sjogren′s syndrome.CLINICAL AND EXPERIMENTAL RHEUMATOLOGY,30(3),322-326.
MLA He, J.,et al."The role of muscarinic acetylcholine receptor type 3 polypeptide (M3RP(205-220)) antibody in the saliva of patients with primary Sjogren′s syndrome".CLINICAL AND EXPERIMENTAL RHEUMATOLOGY 30.3(2012):322-326.
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