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学科主题临床医学
The involvement of Helicobacter pylori thioredoxin-1 in gastric carcinogenesis
Shi, Yanyan1; Liu, Linna1; Zhang, Ting2; Shen, Lijuan3; Liu, Lin2; Zhang, Jing1; Zhang, Yuexia1; Wang, Xuehong3; Yang, Shengsen3; Lu, Fengmin2; Chen, Xiangmei2; Ding, Shigang1
刊名JOURNAL OF MEDICAL MICROBIOLOGY
2013-08-01
DOI10.1099/jmm.0.056903-0
62页:1226-1234
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Microbiology
研究领域[WOS]Microbiology
关键词[WOS]CANCER ; EXPRESSION ; LESIONS ; CAGA ; INFECTION ; APOPTOSIS ; SEQUENCE ; STOMACH ; MARKERS ; SYSTEM
英文摘要

Helicobacter pylori infection is related to the development of gastric diseases. Various virulence factors are responsible for the pathogenic mechanisms of H. pylori infection. Our previous studies using two-dimensional gel electrophoresis showed that H. pylori thioredoxin-1 (Trx1) is overexpressed in gastric carcinomas. Here, we examined whether H. pylori Trx1 is a novel virulence factor associated with gastric tumorigenesis. We found that Trx1 expression in H. pylori isolated from gastric cancer tissues was significantly higher than that from tissues exhibiting gastritis. In the gastric epithelial cell line GES-1, infection of H. pylori with high Trx1 expression significantly induced cell apoptosis, decreased the expression of cyclin D1 and upregulated p21. However, in the gastric cancer cell line BGC823, high Trx1 expression in H. pylori significantly increased cell proliferation, and upregulated cyclin D1. The effects on cell lines were confirmed using the H. pylori Trx1-knockout mutant strain. Our observations indicate that high Trx1 expression in H. pylori is associated with gastric carcinogenesis. In H. pylon, Trx1 likely participates in the pathogenesis of gastric cancer and H. pylori expressing high levels of Trx1 would be expected to be highly pathogenic in gastric diseases in China.

语种英语
WOS记录号WOS:000323865200017
项目编号30770980
资助机构National Natural Science Foundation of China
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50441
专题北京大学第三临床医学院_眼科
北京大学基础医学院
医学人文研究院/公共教学部_哲学与社会科学系
北京大学第三临床医学院_临床流行病学研究中心
北京大学第三临床医学院_消化科
作者单位1.Peking Univ, Hosp 3, Dept Gastroenterol, Beijing 100191, Peoples R China
2.Peking Univ, Dept Microbiol, Hlth Sci Ctr, Beijing 100191, Peoples R China
3.Qinghai Univ, Affiliated Hosp, Dept Gastroenterol, Xining 810001, Peoples R China
推荐引用方式
GB/T 7714
Shi, Yanyan,Liu, Linna,Zhang, Ting,et al. The involvement of Helicobacter pylori thioredoxin-1 in gastric carcinogenesis[J]. JOURNAL OF MEDICAL MICROBIOLOGY,2013,62:1226-1234.
APA Shi, Yanyan.,Liu, Linna.,Zhang, Ting.,Shen, Lijuan.,Liu, Lin.,...&Ding, Shigang.(2013).The involvement of Helicobacter pylori thioredoxin-1 in gastric carcinogenesis.JOURNAL OF MEDICAL MICROBIOLOGY,62,1226-1234.
MLA Shi, Yanyan,et al."The involvement of Helicobacter pylori thioredoxin-1 in gastric carcinogenesis".JOURNAL OF MEDICAL MICROBIOLOGY 62(2013):1226-1234.
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