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学科主题: 临床医学
题名:
The involvement of Helicobacter pylori thioredoxin-1 in gastric carcinogenesis
作者: Shi, Yanyan1; Liu, Linna1; Zhang, Ting2; Shen, Lijuan3; Liu, Lin2; Zhang, Jing1; Zhang, Yuexia1; Wang, Xuehong3; Yang, Shengsen3; Lu, Fengmin2; Chen, Xiangmei2; Ding, Shigang1
刊名: JOURNAL OF MEDICAL MICROBIOLOGY
发表日期: 2013-08-01
DOI: 10.1099/jmm.0.056903-0
卷: 62, 页:1226-1234
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Microbiology
研究领域[WOS]: Microbiology
关键词[WOS]: CANCER ; EXPRESSION ; LESIONS ; CAGA ; INFECTION ; APOPTOSIS ; SEQUENCE ; STOMACH ; MARKERS ; SYSTEM
英文摘要:

Helicobacter pylori infection is related to the development of gastric diseases. Various virulence factors are responsible for the pathogenic mechanisms of H. pylori infection. Our previous studies using two-dimensional gel electrophoresis showed that H. pylori thioredoxin-1 (Trx1) is overexpressed in gastric carcinomas. Here, we examined whether H. pylori Trx1 is a novel virulence factor associated with gastric tumorigenesis. We found that Trx1 expression in H. pylori isolated from gastric cancer tissues was significantly higher than that from tissues exhibiting gastritis. In the gastric epithelial cell line GES-1, infection of H. pylori with high Trx1 expression significantly induced cell apoptosis, decreased the expression of cyclin D1 and upregulated p21. However, in the gastric cancer cell line BGC823, high Trx1 expression in H. pylori significantly increased cell proliferation, and upregulated cyclin D1. The effects on cell lines were confirmed using the H. pylori Trx1-knockout mutant strain. Our observations indicate that high Trx1 expression in H. pylori is associated with gastric carcinogenesis. In H. pylon, Trx1 likely participates in the pathogenesis of gastric cancer and H. pylori expressing high levels of Trx1 would be expected to be highly pathogenic in gastric diseases in China.

语种: 英语
所属项目编号: 30770980
项目资助者: National Natural Science Foundation of China
WOS记录号: WOS:000323865200017
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50441
Appears in Collections:北京大学第三临床医学院_消化科_期刊论文

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作者单位: 1.Peking Univ, Hosp 3, Dept Gastroenterol, Beijing 100191, Peoples R China
2.Peking Univ, Dept Microbiol, Hlth Sci Ctr, Beijing 100191, Peoples R China
3.Qinghai Univ, Affiliated Hosp, Dept Gastroenterol, Xining 810001, Peoples R China

Recommended Citation:
Shi, Yanyan,Liu, Linna,Zhang, Ting,et al. The involvement of Helicobacter pylori thioredoxin-1 in gastric carcinogenesis[J]. JOURNAL OF MEDICAL MICROBIOLOGY,2013,62:1226-1234.
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