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Microbial transformation of three bufadienolides by Penicillium aurantigriseum and its application for metabolite identification in rat
Ma, Xiao-Chi1; Cui, Han1; Zheng, Han1; Guo, De-An1
关键词Bionansformation Bufadienolides Mammalian Metabolism Penicillium Aurantigriseum
刊名JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC
2007-09-03
DOI10.1016/j.molcatb.2007.06.008
48期:1-2页:42-50
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Chemistry, Physical
研究领域[WOS]Biochemistry & Molecular Biology ; Chemistry
关键词[WOS]HUMAN LEUKEMIA-CELLS ; BUFALIN ; CINOBUFAGIN ; DIFFERENTIATION ; JANTHINELLUM
英文摘要

Eighteen strains of filamentous fungi (from nine genera) were screened for their capabilities to transform three major bufadienolides, cinobufagin (1), bufalin (2) and resibufogenin (3), from the traditional Chinese medicine Chan Su. Penicillium aurantigriseum AS 3.4512 was found to be the most potent strain to transform these compounds into in vivo metabolites in rat. Ten transformation products were obtained with high yield and identified using chromatographic and spectral means. Among them, six products were found to be same with the in vitro metabolites transformed by rat liver microsome. Three compounds were the major in vivo metabolites of 1, 2 and 3, respectively. Compound 3a was a firstly reported metabolite of 3 in vivo. All of these suggested the bioconversion of 1, 2 and 3 by P aurantigriseum were very similar with the metabolism of them in vivo, and these transformed products could be used as the reference standards to investigate the mammalian metabolism of bufadienolides. (c) 2007 Elsevier B.V. All rights reserved.

语种英语
WOS记录号WOS:000249091200008
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50442
专题北京大学药学院
北京大学药学院_天然药物与仿生药物国家重点实验室
作者单位1.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China
2.Ctr Univ Natl, Coll Life & Environm Sci, Chinese Minor Tradit Med Ctr, Beijing 100081, Peoples R China
3.Natl Inst Control Biol & Pharmaceut Prod, Beijing 100050, Peoples R China
推荐引用方式
GB/T 7714
Ma, Xiao-Chi,Cui, Han,Zheng, Han,et al. Microbial transformation of three bufadienolides by Penicillium aurantigriseum and its application for metabolite identification in rat[J]. JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC,2007,48(1-2):42-50.
APA Ma, Xiao-Chi,Cui, Han,Zheng, Han,&Guo, De-An.(2007).Microbial transformation of three bufadienolides by Penicillium aurantigriseum and its application for metabolite identification in rat.JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC,48(1-2),42-50.
MLA Ma, Xiao-Chi,et al."Microbial transformation of three bufadienolides by Penicillium aurantigriseum and its application for metabolite identification in rat".JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC 48.1-2(2007):42-50.
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