北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学药学院  > 期刊论文
学科主题: 药学
题名:
Microbial transformation of three bufadienolides by Penicillium aurantigriseum and its application for metabolite identification in rat
作者: Ma, Xiao-Chi1; Cui, Han1; Zheng, Han1; Guo, De-An1
关键词: bionansformation ; bufadienolides ; mammalian metabolism ; Penicillium aurantigriseum
刊名: JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC
发表日期: 2007-09-03
DOI: 10.1016/j.molcatb.2007.06.008
卷: 48, 期:1-2, 页:42-50
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Chemistry, Physical
研究领域[WOS]: Biochemistry & Molecular Biology ; Chemistry
关键词[WOS]: HUMAN LEUKEMIA-CELLS ; BUFALIN ; CINOBUFAGIN ; DIFFERENTIATION ; JANTHINELLUM
英文摘要:

Eighteen strains of filamentous fungi (from nine genera) were screened for their capabilities to transform three major bufadienolides, cinobufagin (1), bufalin (2) and resibufogenin (3), from the traditional Chinese medicine Chan Su. Penicillium aurantigriseum AS 3.4512 was found to be the most potent strain to transform these compounds into in vivo metabolites in rat. Ten transformation products were obtained with high yield and identified using chromatographic and spectral means. Among them, six products were found to be same with the in vitro metabolites transformed by rat liver microsome. Three compounds were the major in vivo metabolites of 1, 2 and 3, respectively. Compound 3a was a firstly reported metabolite of 3 in vivo. All of these suggested the bioconversion of 1, 2 and 3 by P aurantigriseum were very similar with the metabolism of them in vivo, and these transformed products could be used as the reference standards to investigate the mammalian metabolism of bufadienolides. (c) 2007 Elsevier B.V. All rights reserved.

语种: 英语
WOS记录号: WOS:000249091200008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50442
Appears in Collections:北京大学药学院_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China
2.Ctr Univ Natl, Coll Life & Environm Sci, Chinese Minor Tradit Med Ctr, Beijing 100081, Peoples R China
3.Natl Inst Control Biol & Pharmaceut Prod, Beijing 100050, Peoples R China

Recommended Citation:
Ma, Xiao-Chi,Cui, Han,Zheng, Han,et al. Microbial transformation of three bufadienolides by Penicillium aurantigriseum and its application for metabolite identification in rat[J]. JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC,2007,48(1-2):42-50.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Ma, Xiao-Chi]'s Articles
[Cui, Han]'s Articles
[Zheng, Han]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Ma, Xiao-Chi]‘s Articles
[Cui, Han]‘s Articles
[Zheng, Han]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace