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学科主题: 药学
题名:
Microbial transformation of three bufadienolides by Penicillium aurantigriseum and its application for metabolite identification in rat
作者: Ma, Xiao-Chi1; Cui, Han1; Zheng, Han1; Guo, De-An1
关键词: bionansformation ; bufadienolides ; mammalian metabolism ; Penicillium aurantigriseum
刊名: JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC
发表日期: 2007-09-03
DOI: 10.1016/j.molcatb.2007.06.008
卷: 48, 期:1-2, 页:42-50
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Chemistry, Physical
研究领域[WOS]: Biochemistry & Molecular Biology ; Chemistry
关键词[WOS]: HUMAN LEUKEMIA-CELLS ; BUFALIN ; CINOBUFAGIN ; DIFFERENTIATION ; JANTHINELLUM
英文摘要:

Eighteen strains of filamentous fungi (from nine genera) were screened for their capabilities to transform three major bufadienolides, cinobufagin (1), bufalin (2) and resibufogenin (3), from the traditional Chinese medicine Chan Su. Penicillium aurantigriseum AS 3.4512 was found to be the most potent strain to transform these compounds into in vivo metabolites in rat. Ten transformation products were obtained with high yield and identified using chromatographic and spectral means. Among them, six products were found to be same with the in vitro metabolites transformed by rat liver microsome. Three compounds were the major in vivo metabolites of 1, 2 and 3, respectively. Compound 3a was a firstly reported metabolite of 3 in vivo. All of these suggested the bioconversion of 1, 2 and 3 by P aurantigriseum were very similar with the metabolism of them in vivo, and these transformed products could be used as the reference standards to investigate the mammalian metabolism of bufadienolides. (c) 2007 Elsevier B.V. All rights reserved.

语种: 英语
WOS记录号: WOS:000249091200008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50442
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China
2.Ctr Univ Natl, Coll Life & Environm Sci, Chinese Minor Tradit Med Ctr, Beijing 100081, Peoples R China
3.Natl Inst Control Biol & Pharmaceut Prod, Beijing 100050, Peoples R China

Recommended Citation:
Ma, Xiao-Chi,Cui, Han,Zheng, Han,et al. Microbial transformation of three bufadienolides by Penicillium aurantigriseum and its application for metabolite identification in rat[J]. JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC,2007,48(1-2):42-50.
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