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Effects of Chinese herbs combined with in vitro fertilization and embryo transplantation on infertility: a clinical randomized controlled trial
Guo, Jia1; Li, Dong1; Liu, Cheng1; Ji, Xiaolan1; Li, Rang2; Du, Xiaoguo2
关键词Embryo Transfer Fertilization In Vitro Pregnancy Rate Infertility Female Randomized Controlled Trial Drugs Chinese Herbal
刊名JOURNAL OF TRADITIONAL CHINESE MEDICINE
2014-06-15
34期:3页:267-273
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Integrative & Complementary Medicine
研究领域[WOS]Integrative & Complementary Medicine
英文摘要

OBJECTIVE: To assess the effects of using Chinese herbs in assisted reproductive technology.

METHODS: Four hundred and thirty-three subjects aged less than 42 years with infertility due to Fallopian tube or male-related factors who were willing to undertake in vitro fertilization and embryo transplantation were randomly allocated to a Chinese herb intervention group (n=216) or a conventional treatment control group (n=217). All subjects received one of four routine ultra-ovulation-promoting therapies at the Reproductive Center in the Third Hospital Affiliated to Beijing University according to their physician′s assessments. The subjects in the intervention group received various Chinese herbs depending on their conventional treatment. Endometrial thickness, number of acquired eggs, and rates of normal fertility, high-quality embryos, biochemical and clinical pregnancy of subjects were assessed in both groups.

RESULTS: The high-quality embryo rate of 51.9%, biochemical pregnancy rate of 51.0%, clinical pregnancy rate of 44.2% and endometrial thickness of (10.84 +/- 1.75) mm in the intervention group were all significantly higher than those in the control group [48.7%, 38.9%, 34.8%, and (10.52 +/- 1.50) mm, respectively; P<0.05]. The normal fertility rate of 58.5% in the Chinese herb group was also significantly superior to the 54.7% achieved in the control group (P<0.01). There were no statistically significant differences (P>0.05) in the average number of acquired eggs within a single cycle, incidence of excessive stimulation of ovary, rates of embryo transplantation or early abortion and birth of living babies between the two groups.

CONCLUSION: Our findings indicate that Chinese herbs increase endometrial thickness, improve the quality of fertility and embryo, and promote embryonic nidation, thus enhancing the success rate of in vitro fertilization/intracytoplasmic sperm injection-embryo transplantation cycle. Using Chinese herbs improves the outcomes and safety of assisted reproductive technologies. (C) 2014 JTCM. All rights reserved.

语种英语
WOS记录号WOS:000337656700004
项目编号SF-2009-III-33
资助机构Capital Fund for Development of Medical Science and Technology
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50443
专题北京大学第三临床医学院_中医科
北京大学第一临床医学院_病理科
作者单位1.Beijing Univ, Hosp 3, Dept Tradit Chinese Med, Beijing 100191, Peoples R China
2.Beijing Univ, Hosp 3, Reprod Ctr, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Guo, Jia,Li, Dong,Liu, Cheng,et al. Effects of Chinese herbs combined with in vitro fertilization and embryo transplantation on infertility: a clinical randomized controlled trial[J]. JOURNAL OF TRADITIONAL CHINESE MEDICINE,2014,34(3):267-273.
APA Guo, Jia,Li, Dong,Liu, Cheng,Ji, Xiaolan,Li, Rang,&Du, Xiaoguo.(2014).Effects of Chinese herbs combined with in vitro fertilization and embryo transplantation on infertility: a clinical randomized controlled trial.JOURNAL OF TRADITIONAL CHINESE MEDICINE,34(3),267-273.
MLA Guo, Jia,et al."Effects of Chinese herbs combined with in vitro fertilization and embryo transplantation on infertility: a clinical randomized controlled trial".JOURNAL OF TRADITIONAL CHINESE MEDICINE 34.3(2014):267-273.
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