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Immunoexpression of matrix metalloproteinase-2 and matrix metalloproteinase-9 in the metastasis of squamous cell carcinoma of the human tongue
Zhou, C. X.1,2,3; Gao, Y.3; Johnson, N. W.1,2; Gao, J.1,2
关键词Matrix Metalloproteinase-2 Matrix Metalloproteinase-9 Oral Squamous Cell Carcinoma Tongue Cancer Metastasis
刊名AUSTRALIAN DENTAL JOURNAL
2010-12-01
DOI10.1111/j.1834-7819.2010.01258.x
55期:4页:385-389
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Dentistry, Oral Surgery & Medicine
研究领域[WOS]Dentistry, Oral Surgery & Medicine
关键词[WOS]TISSUE INHIBITORS ; GENE-EXPRESSION ; TUMOR INVASION ; ORAL-CAVITY ; CANCER ; TIMP-2 ; ROLES ; MMP-2 ; NECK
英文摘要

Background: Squamous cell carcinoma of the tongue has frequent lymph node metastases and poor prognosis. Matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9) are reported to degrade basement membrane, facilitating invasion and metastasis. This study determined the expression of MMP-2/MMP-9 in primary tongue cancer with or without cervical metastases and analysed the significance of such expression in relation to the presence or absence of metastases.

Methods: Expressions of MMP-2/MMP-9 were detected by immunohistochemistry in 10 specimens of normal oral mucosa, 20 lymph node-negative tongue cancers, 41 lymph node-positive tongue cancers and their metastasized tumours in cervical lymph nodes.

Results: MMP-2/MMP-9 expression was seldom found in normal epithelium. In lymph node-negative tongue cancer, 45% and 40% of these primary tumours were positively stained for MMP-2/MMP-9, respectively. Importantly, in lymph node-positive tongue cancer, 71% and 79% of these primary tumours were positive for MMP-2/MMP-9, respectively. Overexpression of MMP-2/MMP-9 was present in the metastatic lymph nodes.

Conclusions: Our results imply that MMP-2 and/or MMP-9 play an important role in invasion and metastasis in tongue cancer, and that analysis of MMP expression and/or activity in primary tumours may have a predictive value for the actual or potential presence of cervical metastases.

语种英语
WOS记录号WOS:000285062700006
资助机构National Health and Medical Research Council Australia ; Australian Dental Research Foundation
引用统计
被引频次:35[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50447
专题北京大学口腔医学院_口腔病理科
作者单位1.Griffith Univ, Sch Dent & Oral Hlth, Gold Coast, Qld, Australia
2.Griffith Univ, Griffith Hlth Inst, Gold Coast, Qld, Australia
3.Peking Univ, Sch Stomatol, Dept Oral Pathol, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Zhou, C. X.,Gao, Y.,Johnson, N. W.,et al. Immunoexpression of matrix metalloproteinase-2 and matrix metalloproteinase-9 in the metastasis of squamous cell carcinoma of the human tongue[J]. AUSTRALIAN DENTAL JOURNAL,2010,55(4):385-389.
APA Zhou, C. X.,Gao, Y.,Johnson, N. W.,&Gao, J..(2010).Immunoexpression of matrix metalloproteinase-2 and matrix metalloproteinase-9 in the metastasis of squamous cell carcinoma of the human tongue.AUSTRALIAN DENTAL JOURNAL,55(4),385-389.
MLA Zhou, C. X.,et al."Immunoexpression of matrix metalloproteinase-2 and matrix metalloproteinase-9 in the metastasis of squamous cell carcinoma of the human tongue".AUSTRALIAN DENTAL JOURNAL 55.4(2010):385-389.
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