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学科主题: 口腔医学
题名:
Immunoexpression of matrix metalloproteinase-2 and matrix metalloproteinase-9 in the metastasis of squamous cell carcinoma of the human tongue
作者: Zhou, C. X.1,2,3; Gao, Y.3; Johnson, N. W.1,2; Gao, J.1,2
关键词: Matrix metalloproteinase-2 ; matrix metalloproteinase-9 ; oral squamous cell carcinoma ; tongue cancer ; metastasis
刊名: AUSTRALIAN DENTAL JOURNAL
发表日期: 2010-12-01
DOI: 10.1111/j.1834-7819.2010.01258.x
卷: 55, 期:4, 页:385-389
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Dentistry, Oral Surgery & Medicine
研究领域[WOS]: Dentistry, Oral Surgery & Medicine
关键词[WOS]: TISSUE INHIBITORS ; GENE-EXPRESSION ; TUMOR INVASION ; ORAL-CAVITY ; CANCER ; TIMP-2 ; ROLES ; MMP-2 ; NECK
英文摘要:

Background: Squamous cell carcinoma of the tongue has frequent lymph node metastases and poor prognosis. Matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9) are reported to degrade basement membrane, facilitating invasion and metastasis. This study determined the expression of MMP-2/MMP-9 in primary tongue cancer with or without cervical metastases and analysed the significance of such expression in relation to the presence or absence of metastases.

Methods: Expressions of MMP-2/MMP-9 were detected by immunohistochemistry in 10 specimens of normal oral mucosa, 20 lymph node-negative tongue cancers, 41 lymph node-positive tongue cancers and their metastasized tumours in cervical lymph nodes.

Results: MMP-2/MMP-9 expression was seldom found in normal epithelium. In lymph node-negative tongue cancer, 45% and 40% of these primary tumours were positively stained for MMP-2/MMP-9, respectively. Importantly, in lymph node-positive tongue cancer, 71% and 79% of these primary tumours were positive for MMP-2/MMP-9, respectively. Overexpression of MMP-2/MMP-9 was present in the metastatic lymph nodes.

Conclusions: Our results imply that MMP-2 and/or MMP-9 play an important role in invasion and metastasis in tongue cancer, and that analysis of MMP expression and/or activity in primary tumours may have a predictive value for the actual or potential presence of cervical metastases.

语种: 英语
项目资助者: National Health and Medical Research Council Australia ; Australian Dental Research Foundation
WOS记录号: WOS:000285062700006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50447
Appears in Collections:北京大学口腔医学院_口腔病理科_期刊论文

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作者单位: 1.Griffith Univ, Sch Dent & Oral Hlth, Gold Coast, Qld, Australia
2.Griffith Univ, Griffith Hlth Inst, Gold Coast, Qld, Australia
3.Peking Univ, Sch Stomatol, Dept Oral Pathol, Beijing 100871, Peoples R China

Recommended Citation:
Zhou, C. X.,Gao, Y.,Johnson, N. W.,et al. Immunoexpression of matrix metalloproteinase-2 and matrix metalloproteinase-9 in the metastasis of squamous cell carcinoma of the human tongue[J]. AUSTRALIAN DENTAL JOURNAL,2010,55(4):385-389.
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