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学科主题: 临床医学
题名:
Synthesis and radiolabeling of In-111-core-cross linked polymeric micelle-octreotide for near-infrared fluoroscopy and single photon emission computed tomography imaging
作者: Hong, Ye1,2; Zhu, Hua1; Hu, Ji2; Lin, Xinfeng1; Wang, Feng1; Li, Chun3; Yang, Zhi1
关键词: Dual-modality imaging ; Tumor detection ; Octreotide ; Near-infrared fluoroscopy ; Single photon emission computed ; tomography
刊名: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
发表日期: 2014-06-15
DOI: 10.1016/j.bmcl.2014.03.050
卷: 24, 期:12, 页:2781-2785
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Medicinal ; Chemistry, Organic
研究领域[WOS]: Pharmacology & Pharmacy ; Chemistry
关键词[WOS]: BIOLOGICAL EVALUATION ; INDOCYANINE GREEN ; PEPTIDE ; SOMATOSTATIN ; CANCER ; PROLIFERATION ; NANOPARTICLES ; CONJUGATION ; INHIBITION ; SURGERY
英文摘要:

The objective of this study was the development of a dual-modality imaging device, namely In-111-core-cross-linked polymeric micelle (CCPM)-octreotide, for neuroendocrine tumor detection, using near-infrared fluoroscopy (NIRF) and single photon emission computed tomography (SPECT). The tumor targeting ability of the In-111-labeled CCPM-octreotide was evaluated in a tumor mouse model. SPECT/CT, NIRF and gamma imaging results showed high tumor uptake of In-111-labeled CCPM-octreotide. In contrast, there was a much lower signal in the same mouse model injected with In-111-labeled CCPM. The high accumulation of In-111-labeled CCPM-octreotide in U87 tumor was reduced after co-injection with an excess amount of CCPM-octreotide. These results suggested CCPM-octreotide′s potential applications in tumor diagnosis, drug delivery and molecular imaging. (C) 2014 Elsevier Ltd. All rights reserved.

语种: 英语
所属项目编号: 81071198 ; 81172082 ; 81371592 ; 7132040
项目资助者: National Natural Science Foundation of China ; Beijing Natural Science Foundation
WOS记录号: WOS:000335921200040
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50457
Appears in Collections:北京大学临床肿瘤学院_核医学科_期刊论文

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作者单位: 1.Peking Univ, Canc Hosp & Inst, Dept Nucl Med, Key Lab Carcinogenesis & Translat Res,Minist Educ, Beijing 100142, Peoples R China
2.China Inst Atom Energy, Dept Isotope, Beijing 102413, Peoples R China
3.Univ Texas MD Anderson Canc Ctr, Dept Expt Diagnost Imaging, Houston, TX 77030 USA

Recommended Citation:
Hong, Ye,Zhu, Hua,Hu, Ji,et al. Synthesis and radiolabeling of In-111-core-cross linked polymeric micelle-octreotide for near-infrared fluoroscopy and single photon emission computed tomography imaging[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2014,24(12):2781-2785.
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