北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学临床肿瘤学院  > 核医学科  > 期刊论文
学科主题: 临床医学
题名:
Synthesis and radiolabeling of In-111-core-cross linked polymeric micelle-octreotide for near-infrared fluoroscopy and single photon emission computed tomography imaging
作者: Hong, Ye1,2; Zhu, Hua1; Hu, Ji2; Lin, Xinfeng1; Wang, Feng1; Li, Chun3; Yang, Zhi1
关键词: Dual-modality imaging ; Tumor detection ; Octreotide ; Near-infrared fluoroscopy ; Single photon emission computed ; tomography
刊名: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
发表日期: 2014-06-15
DOI: 10.1016/j.bmcl.2014.03.050
卷: 24, 期:12, 页:2781-2785
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Medicinal ; Chemistry, Organic
研究领域[WOS]: Pharmacology & Pharmacy ; Chemistry
关键词[WOS]: BIOLOGICAL EVALUATION ; INDOCYANINE GREEN ; PEPTIDE ; SOMATOSTATIN ; CANCER ; PROLIFERATION ; NANOPARTICLES ; CONJUGATION ; INHIBITION ; SURGERY
英文摘要:

The objective of this study was the development of a dual-modality imaging device, namely In-111-core-cross-linked polymeric micelle (CCPM)-octreotide, for neuroendocrine tumor detection, using near-infrared fluoroscopy (NIRF) and single photon emission computed tomography (SPECT). The tumor targeting ability of the In-111-labeled CCPM-octreotide was evaluated in a tumor mouse model. SPECT/CT, NIRF and gamma imaging results showed high tumor uptake of In-111-labeled CCPM-octreotide. In contrast, there was a much lower signal in the same mouse model injected with In-111-labeled CCPM. The high accumulation of In-111-labeled CCPM-octreotide in U87 tumor was reduced after co-injection with an excess amount of CCPM-octreotide. These results suggested CCPM-octreotide′s potential applications in tumor diagnosis, drug delivery and molecular imaging. (C) 2014 Elsevier Ltd. All rights reserved.

语种: 英语
所属项目编号: 81071198 ; 81172082 ; 81371592 ; 7132040
项目资助者: National Natural Science Foundation of China ; Beijing Natural Science Foundation
WOS记录号: WOS:000335921200040
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50457
Appears in Collections:北京大学临床肿瘤学院_核医学科_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Peking Univ, Canc Hosp & Inst, Dept Nucl Med, Key Lab Carcinogenesis & Translat Res,Minist Educ, Beijing 100142, Peoples R China
2.China Inst Atom Energy, Dept Isotope, Beijing 102413, Peoples R China
3.Univ Texas MD Anderson Canc Ctr, Dept Expt Diagnost Imaging, Houston, TX 77030 USA

Recommended Citation:
Hong, Ye,Zhu, Hua,Hu, Ji,et al. Synthesis and radiolabeling of In-111-core-cross linked polymeric micelle-octreotide for near-infrared fluoroscopy and single photon emission computed tomography imaging[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2014,24(12):2781-2785.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Hong, Ye]'s Articles
[Zhu, Hua]'s Articles
[Hu, Ji]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Hong, Ye]‘s Articles
[Zhu, Hua]‘s Articles
[Hu, Ji]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace