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Synthesis and radiolabeling of In-111-core-cross linked polymeric micelle-octreotide for near-infrared fluoroscopy and single photon emission computed tomography imaging
Hong, Ye1,2; Zhu, Hua1; Hu, Ji2; Lin, Xinfeng1; Wang, Feng1; Li, Chun3; Yang, Zhi1
关键词Dual-modality Imaging Tumor Detection Octreotide Near-infrared Fluoroscopy Single Photon Emission Computed Tomography
刊名BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
2014-06-15
DOI10.1016/j.bmcl.2014.03.050
24期:12页:2781-2785
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Medicinal ; Chemistry, Organic
研究领域[WOS]Pharmacology & Pharmacy ; Chemistry
关键词[WOS]BIOLOGICAL EVALUATION ; INDOCYANINE GREEN ; PEPTIDE ; SOMATOSTATIN ; CANCER ; PROLIFERATION ; NANOPARTICLES ; CONJUGATION ; INHIBITION ; SURGERY
英文摘要

The objective of this study was the development of a dual-modality imaging device, namely In-111-core-cross-linked polymeric micelle (CCPM)-octreotide, for neuroendocrine tumor detection, using near-infrared fluoroscopy (NIRF) and single photon emission computed tomography (SPECT). The tumor targeting ability of the In-111-labeled CCPM-octreotide was evaluated in a tumor mouse model. SPECT/CT, NIRF and gamma imaging results showed high tumor uptake of In-111-labeled CCPM-octreotide. In contrast, there was a much lower signal in the same mouse model injected with In-111-labeled CCPM. The high accumulation of In-111-labeled CCPM-octreotide in U87 tumor was reduced after co-injection with an excess amount of CCPM-octreotide. These results suggested CCPM-octreotide′s potential applications in tumor diagnosis, drug delivery and molecular imaging. (C) 2014 Elsevier Ltd. All rights reserved.

语种英语
WOS记录号WOS:000335921200040
项目编号81071198 ; 81172082 ; 81371592 ; 7132040
资助机构National Natural Science Foundation of China ; Beijing Natural Science Foundation
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50457
专题北京大学临床肿瘤学院_核医学科
作者单位1.Peking Univ, Canc Hosp & Inst, Dept Nucl Med, Key Lab Carcinogenesis & Translat Res,Minist Educ, Beijing 100142, Peoples R China
2.China Inst Atom Energy, Dept Isotope, Beijing 102413, Peoples R China
3.Univ Texas MD Anderson Canc Ctr, Dept Expt Diagnost Imaging, Houston, TX 77030 USA
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GB/T 7714
Hong, Ye,Zhu, Hua,Hu, Ji,et al. Synthesis and radiolabeling of In-111-core-cross linked polymeric micelle-octreotide for near-infrared fluoroscopy and single photon emission computed tomography imaging[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2014,24(12):2781-2785.
APA Hong, Ye.,Zhu, Hua.,Hu, Ji.,Lin, Xinfeng.,Wang, Feng.,...&Yang, Zhi.(2014).Synthesis and radiolabeling of In-111-core-cross linked polymeric micelle-octreotide for near-infrared fluoroscopy and single photon emission computed tomography imaging.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,24(12),2781-2785.
MLA Hong, Ye,et al."Synthesis and radiolabeling of In-111-core-cross linked polymeric micelle-octreotide for near-infrared fluoroscopy and single photon emission computed tomography imaging".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 24.12(2014):2781-2785.
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