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NBS-mediated sequential one-pot synthesis of multifunctionalized thiazoles and thiophenes from 1,3-dicarbonyl compounds and mercaptonitrile salts
Luo, Laichun; Meng, Lanlan; Sun, Qi; Ge, Zemei; Li, Runtao
关键词Multifunctionalized Thiazoles And Thiophenes Sequential One-pot Synthesis Thorpe-ziegler Cyclization Nbs 1 3-dicarbonyl Compounds
刊名TETRAHEDRON LETTERS
2014
DOI10.1016/j.tetlet.2013.11.014
55期:1页:259-263
收录类别SCI ; IC ; CCR
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Organic
研究领域[WOS]Chemistry
关键词[WOS]SOLID-PHASE SYNTHESIS ; THORPE-ZIEGLER CYCLIZATION ; BIOLOGICAL EVALUATION ; MULTICOMPONENT REACTION ; ALPHA-HALOGENATION ; PI3K INHIBITORS ; DERIVATIVES ; BROMINATION ; DISCOVERY ; DESIGN
英文摘要

A NBS-mediated sequential one-pot synthesis of multifunctionalized thiazoles and thiophenes from 1,3-dicarbonyl compounds and mercaptonitrile salts has been developed under mild conditions. This transformation involves sequential bromination/S(N)2 alkylation/Thorpe-Ziegler cyclization/regio-selective elimination of a -COR group, affording the desired products in moderate to good yields. The sequence of the leaving reactivity of -COR groups was determined and a possible mechanism was proposed. (C) 2013 Elsevier Ltd. All rights reserved.

语种英语
WOS记录号WOS:000329960500058
项目编号NSFC 21172011 ; 21272009
资助机构National Natural Science Foundation of China
引用统计
被引频次:15[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50465
专题北京大学药学院
北京大学药学院_化学生物学系
作者单位Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Luo, Laichun,Meng, Lanlan,Sun, Qi,et al. NBS-mediated sequential one-pot synthesis of multifunctionalized thiazoles and thiophenes from 1,3-dicarbonyl compounds and mercaptonitrile salts[J]. TETRAHEDRON LETTERS,2014,55(1):259-263.
APA Luo, Laichun,Meng, Lanlan,Sun, Qi,Ge, Zemei,&Li, Runtao.(2014).NBS-mediated sequential one-pot synthesis of multifunctionalized thiazoles and thiophenes from 1,3-dicarbonyl compounds and mercaptonitrile salts.TETRAHEDRON LETTERS,55(1),259-263.
MLA Luo, Laichun,et al."NBS-mediated sequential one-pot synthesis of multifunctionalized thiazoles and thiophenes from 1,3-dicarbonyl compounds and mercaptonitrile salts".TETRAHEDRON LETTERS 55.1(2014):259-263.
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