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学科主题: 药学
题名:
NBS-mediated sequential one-pot synthesis of multifunctionalized thiazoles and thiophenes from 1,3-dicarbonyl compounds and mercaptonitrile salts
作者: Luo, Laichun; Meng, Lanlan; Sun, Qi; Ge, Zemei; Li, Runtao
关键词: Multifunctionalized thiazoles and thiophenes ; Sequential one-pot synthesis ; Thorpe-Ziegler cyclization ; 1,3-Dicarbonyl compounds ; NBS
刊名: TETRAHEDRON LETTERS
发表日期: 2014
DOI: 10.1016/j.tetlet.2013.11.014
卷: 55, 期:1, 页:259-263
收录类别: SCI ; IC ; CCR
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Organic
研究领域[WOS]: Chemistry
关键词[WOS]: SOLID-PHASE SYNTHESIS ; THORPE-ZIEGLER CYCLIZATION ; BIOLOGICAL EVALUATION ; MULTICOMPONENT REACTION ; ALPHA-HALOGENATION ; PI3K INHIBITORS ; DERIVATIVES ; BROMINATION ; DISCOVERY ; DESIGN
英文摘要:

A NBS-mediated sequential one-pot synthesis of multifunctionalized thiazoles and thiophenes from 1,3-dicarbonyl compounds and mercaptonitrile salts has been developed under mild conditions. This transformation involves sequential bromination/S(N)2 alkylation/Thorpe-Ziegler cyclization/regio-selective elimination of a -COR group, affording the desired products in moderate to good yields. The sequence of the leaving reactivity of -COR groups was determined and a possible mechanism was proposed. (C) 2013 Elsevier Ltd. All rights reserved.

语种: 英语
所属项目编号: NSFC 21172011 ; 21272009
项目资助者: National Natural Science Foundation of China
WOS记录号: WOS:000329960500058
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50465
Appears in Collections:北京大学药学院_期刊论文

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作者单位: Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China

Recommended Citation:
Luo, Laichun,Meng, Lanlan,Sun, Qi,et al. NBS-mediated sequential one-pot synthesis of multifunctionalized thiazoles and thiophenes from 1,3-dicarbonyl compounds and mercaptonitrile salts[J]. TETRAHEDRON LETTERS,2014,55(1):259-263.
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