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Central Sensitization and MAPKs Are Involved in Occlusal Interference-Induced Facial Pain in Rats
Cao, Ye1; Li, Kai2,3; Fu, Kai-Yuan2; Xie, Qiu-Fei1; Chiang, Chen-Yu4; Sessle, Barry J.4
关键词Occlusal Interference Hypersensitivity Trigeminal Subnucleus Caudalis Central Sensitization Glia Mitogen-activated Protein Kinases
刊名JOURNAL OF PAIN
2013-08-01
DOI10.1016/j.jpain.2013.02.005
14期:8页:793-807
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Clinical Neurology ; Neurosciences
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]MEDULLARY DORSAL-HORN ; SPINAL SUBNUCLEUS CAUDALIS ; INFERIOR ALVEOLAR NERVE ; NOCICEPTIVE NEURONS ; NEUROPATHIC PAIN ; TEMPOROMANDIBULAR DISORDERS ; MECHANICAL ALLODYNIA ; INFRAORBITAL NERVE ; PATHOLOGICAL PAIN ; GLIAL ACTIVATION
英文摘要

We previously developed a rat dental occlusal interference model of facial pain that was produced by bonding a crown onto the right maxillary first molar and was reflected in sustained facial hypersensitivity that was suggestive of the involvement of central sensitization mechanisms. The aim of the present study was to investigate potential central mechanisms involved in the occlusal interference-induced facial hypersensitivity. A combination of behavioral, immunohistochemical, Western blot, and electrophysiological recording procedures was used in 98 male adult Sprague Dawley rats that either received the occlusal interference or were sham-operated or naive rats. Immunohistochemically labeled astrocytes and microglia in trigeminal subnucleus caudalis (Vc) showed morphological changes indicative of astrocyte and microglial activation after the occlusal interference. Prolonged upregulation of p38 mitogen-activated protein kinase (MAPK) and extracellular signal-regulated kinase (ERK) was also documented in Vc after placement of the occlusal interference and was expressed in both neurons and glial cells at time points when rats showed peak mechanical facial hypersensitivity. The intrathecal administration of the p38 MAPK inhibitor 5B203580 to the medulla significantly inhibited the occlusal interference-induced hypersensitivity, and the ERK inhibitor PD98059 produced an even stronger effect. Central sensitization of functionally identified Vc nociceptive neurons following placement of the occlusal interference was also documented by extracellular electrophysiological recordings, and intrathecal administration of PD98059 could reverse the neuronal central sensitization. These novel findings suggest that central mechanisms including central sensitization of trigeminal nociceptive neurons and non-neuronal processes involving MAPKs play significant roles in the production of occlusal interference-induced facial pain.

Perspective: Central mechanisms including trigeminal nociceptive neuronal sensitization, non-neuronal processes involving glial activation, and MAPKs play significant roles in occlusal interference-induced facial pain. These mechanisms may be Involved in clinical manifestations of facial pain that have been reported in patients with an occlusal interference. (C) 2013 by the American Pain Society

语种英语
WOS记录号WOS:000323020300003
项目编号81000452 ; 30973337 ; bmu2009139 ; DE04786 ; MOP4918
资助机构National Natural Science Foundation of Youth Fund ; National Natural Science Foundation ; Talent Introduction Project of Peking University Health Science Center ; US National Institutes of Health ; CIHR
引用统计
被引频次:15[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50469
专题北京大学口腔医学院_口腔修复科
北京大学公共卫生学院_公共卫生学院
北京大学口腔医学院_口腔放射科
作者单位1.Peking Univ, Dept Prosthodont, Sch & Hosp Stomatol, Beijing 100081, Peoples R China
2.Peking Univ, Ctr TMD & Orofacial Pain, Sch & Hosp Stomatol, Beijing 100081, Peoples R China
3.Peking Univ, Dept Gen Dent 2, Sch & Hosp Stomatol, Beijing 100081, Peoples R China
4.Univ Toronto, Fac Dent, Toronto, ON, Canada
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GB/T 7714
Cao, Ye,Li, Kai,Fu, Kai-Yuan,et al. Central Sensitization and MAPKs Are Involved in Occlusal Interference-Induced Facial Pain in Rats[J]. JOURNAL OF PAIN,2013,14(8):793-807.
APA Cao, Ye,Li, Kai,Fu, Kai-Yuan,Xie, Qiu-Fei,Chiang, Chen-Yu,&Sessle, Barry J..(2013).Central Sensitization and MAPKs Are Involved in Occlusal Interference-Induced Facial Pain in Rats.JOURNAL OF PAIN,14(8),793-807.
MLA Cao, Ye,et al."Central Sensitization and MAPKs Are Involved in Occlusal Interference-Induced Facial Pain in Rats".JOURNAL OF PAIN 14.8(2013):793-807.
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