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学科主题: 临床医学
题名:
Homocysteine induces production of monocyte chemoattractant protein-1 and interleukin-8 in cultured human whole blood
作者: Zeng, XK1; Remick, DG1; Wang, X1
关键词: atherosclerosis ; monocyte chemoattractant protein-1 ; interleukin-8 ; homocysteine ; monocytes
刊名: ACTA PHARMACOLOGICA SINICA
发表日期: 2004-11-01
卷: 25, 期:11, 页:1419-1425
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Multidisciplinary ; Pharmacology & Pharmacy
研究领域[WOS]: Chemistry ; Pharmacology & Pharmacy
关键词[WOS]: SMOOTH-MUSCLE CELLS ; RISK-FACTOR ; ENDOTHELIAL DYSFUNCTION ; PLASMA HOMOCYST(E)INE ; ATHEROMATOUS PLAQUES ; VENOUS THROMBOSIS ; VASCULAR-DISEASE ; KAPPA-B ; EXPRESSION ; HYPERHOMOCYSTEINEMIA
英文摘要:

AIM: To investigate whether increased plasma L-homocysteine (Hcy) level could promote monocyte chemoattractant protein-1 (MCP-1) and interleukin-8 (IL-8) in cultured whole blood.

METHODS: Human whole blood or different type of peripheral blood cells from health volunteers were incubated with Hcy and/or the inhibitors. MCP-1 and IL-8 level were measured by ELISA assay.

RESULTS: Hcy 10-1000 mumol/L induced production of MCP-1 and IL-8 in cultured human whole blood (P<0.05). The major cellular source of these chemokines comed from monocytes. Meanwhile,Hcy also promoted the upregulation of MPO level even at the 10 mumol/L in the cultured whole blood. The intracellular ROS, particular the OH′ radicals, play extremely important role in the Hcy-induced MCP-1 and IL8 production.

CONCLUSION: Increased Hcy level in plasma (hyperhomocysteinemia) induced MCP-1 and IL-8 secretion in cultured human whole blood, especially in monocytes via oxidative stress mechanism.

语种: 英语
WOS记录号: WOS:000224947400006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50470
Appears in Collections:北京大学第三临床医学院_心血管内科_期刊论文

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作者单位: 1.Peking Univ, Hosp 3, Inst Vasc Med, Beijing 100083, Peoples R China
2.Peking Univ, Basic Med Coll, Dept Physiol, Beijing 100083, Peoples R China
3.Peking Univ, Key Lab Mol Cardiovasc Sci Educ Minist, Beijing 100083, Peoples R China
4.Univ Michigan, Sch Med, Dept Pathol, Ann Arbor, MI 48109 USA

Recommended Citation:
Zeng, XK,Remick, DG,Wang, X. Homocysteine induces production of monocyte chemoattractant protein-1 and interleukin-8 in cultured human whole blood[J]. ACTA PHARMACOLOGICA SINICA,2004,25(11):1419-1425.
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