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学科主题临床医学
Homocysteine induces production of monocyte chemoattractant protein-1 and interleukin-8 in cultured human whole blood
Zeng, XK1; Remick, DG1; Wang, X1
关键词Atherosclerosis Monocyte Chemoattractant Protein-1 Interleukin-8 Homocysteine Monocytes
刊名ACTA PHARMACOLOGICA SINICA
2004-11-01
25期:11页:1419-1425
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Multidisciplinary ; Pharmacology & Pharmacy
研究领域[WOS]Chemistry ; Pharmacology & Pharmacy
关键词[WOS]SMOOTH-MUSCLE CELLS ; RISK-FACTOR ; ENDOTHELIAL DYSFUNCTION ; PLASMA HOMOCYST(E)INE ; ATHEROMATOUS PLAQUES ; VENOUS THROMBOSIS ; VASCULAR-DISEASE ; KAPPA-B ; EXPRESSION ; HYPERHOMOCYSTEINEMIA
英文摘要

AIM: To investigate whether increased plasma L-homocysteine (Hcy) level could promote monocyte chemoattractant protein-1 (MCP-1) and interleukin-8 (IL-8) in cultured whole blood.

METHODS: Human whole blood or different type of peripheral blood cells from health volunteers were incubated with Hcy and/or the inhibitors. MCP-1 and IL-8 level were measured by ELISA assay.

RESULTS: Hcy 10-1000 mumol/L induced production of MCP-1 and IL-8 in cultured human whole blood (P<0.05). The major cellular source of these chemokines comed from monocytes. Meanwhile,Hcy also promoted the upregulation of MPO level even at the 10 mumol/L in the cultured whole blood. The intracellular ROS, particular the OH′ radicals, play extremely important role in the Hcy-induced MCP-1 and IL8 production.

CONCLUSION: Increased Hcy level in plasma (hyperhomocysteinemia) induced MCP-1 and IL-8 secretion in cultured human whole blood, especially in monocytes via oxidative stress mechanism.

语种英语
WOS记录号WOS:000224947400006
引用统计
被引频次:13[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50470
专题北京大学第三临床医学院_心血管内科
北京大学基础医学院
作者单位1.Peking Univ, Hosp 3, Inst Vasc Med, Beijing 100083, Peoples R China
2.Peking Univ, Basic Med Coll, Dept Physiol, Beijing 100083, Peoples R China
3.Peking Univ, Key Lab Mol Cardiovasc Sci Educ Minist, Beijing 100083, Peoples R China
4.Univ Michigan, Sch Med, Dept Pathol, Ann Arbor, MI 48109 USA
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GB/T 7714
Zeng, XK,Remick, DG,Wang, X. Homocysteine induces production of monocyte chemoattractant protein-1 and interleukin-8 in cultured human whole blood[J]. ACTA PHARMACOLOGICA SINICA,2004,25(11):1419-1425.
APA Zeng, XK,Remick, DG,&Wang, X.(2004).Homocysteine induces production of monocyte chemoattractant protein-1 and interleukin-8 in cultured human whole blood.ACTA PHARMACOLOGICA SINICA,25(11),1419-1425.
MLA Zeng, XK,et al."Homocysteine induces production of monocyte chemoattractant protein-1 and interleukin-8 in cultured human whole blood".ACTA PHARMACOLOGICA SINICA 25.11(2004):1419-1425.
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