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学科主题临床医学
Modified C-Reactive Protein Might be a Target Autoantigen of TINU Syndrome
Tan, Ying1,3; Yu, Feng1,3; Qu, Zhen1,3; Su, Tao1,3; Xing, Guang-Qun1,3; Wu, Li-Hua1,3; Wang, Feng-Mei1,3; Liu, Gang1,3; Yang, Liu2; Zhao, Ming-Hui1,3
刊名CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
2011
DOI10.2215/CJN.09051209
6期:1页:93-100
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Urology & Nephrology
资助者National Natural Science Foundation for Distinguished Young Scholars ; Beijing Natural Science Foundation ; Program for New Century Excellent Talent in University ; National Natural Science Foundation for Distinguished Young Scholars ; Beijing Natural Science Foundation ; Program for New Century Excellent Talent in University
研究领域[WOS]Urology & Nephrology
关键词[WOS]TUBULAR BASEMENT-MEMBRANE ; TUBULOINTERSTITIAL NEPHRITIS ; UVEITIS SYNDROME ; INTERSTITIAL NEPHRITIS ; COMPLEMENT ACTIVATION ; ANTERIOR UVEITIS ; CELLS ; KIDNEY ; AUTOANTIBODIES ; PATHOLOGY
英文摘要

Background and objectives The cross-reactive antigen(s) of tubulointerstitial nephritis and uveitis (TINU) syndrome from renal tubulointerstitia and ocular tissue remain unidentified. The authors′ recent study demonstrated that the presence of serum IgG autoantibodies against modified C-reactive protein (mCRP) was closely associated with the intensity of tubulointerstitial lesions in lupus nephritis. The study presented here investigates the possible role of IgG autoantibodies against mCRP in patients with TINU syndrome.

Design, setting, participants, & measurements mCRP autoantibodies were screened by ELISA with purified human C-reactive protein in 9 patients with TINU syndrome, 11 with drug-associated acute interstitial nephritis, 20 with IgA nephropathy, 19 with minimal change disease, 20 with ANCA-associated vasculitis, 6 with Sjogren′s syndrome, and 12 with amyloidosis. mCRP expression was analyzed by immunohistochemistry in renal biopsy specimens from the 9 patients with TINU syndrome and 40 from disease controls. Frozen normal human kidney and iris were used to demonstrate co-localization of human IgG and mCRP from patients with TINU syndrome with laser scanning confocal microscopy.

Results The mCRP autoantibodies were detected in all nine patients with TINU syndrome, significantly higher than that of those with disease controls (P < 0.05). The renal histologic score of mCRP in TINU syndrome was significantly higher than that in disease controls (P < 0.05). The staining of mCRP and human IgG were co-localized in renal and ocular tissues.

Conclusions It is concluded that mCRP might be a target autoantigen in TINU syndrome. Clin J Am Soc Nephrol 6: 93-100, 2011. doi: 10.2215/CJN.09051209

语种英语
所属项目编号30725034 ; 7102150 ; BMU 20100013
资助者National Natural Science Foundation for Distinguished Young Scholars ; Beijing Natural Science Foundation ; Program for New Century Excellent Talent in University ; National Natural Science Foundation for Distinguished Young Scholars ; Beijing Natural Science Foundation ; Program for New Century Excellent Talent in University
WOS记录号WOS:000286452900014
Citation statistics
Cited Times:31[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50472
Collection北京大学第一临床医学院_肾脏内科
作者单位1.Peking Univ, Hosp 1, Div Renal, Dept Med, Beijing, Peoples R China
2.Peking Univ, Hosp 1, Dept Ophthalmol, Beijing, Peoples R China
3.Minist Hlth China, Peking Univ Key Lab Renal Dis, Inst Nephrol, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Tan, Ying,Yu, Feng,Qu, Zhen,et al. Modified C-Reactive Protein Might be a Target Autoantigen of TINU Syndrome[J]. CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY,2011,6(1):93-100.
APA Tan, Ying.,Yu, Feng.,Qu, Zhen.,Su, Tao.,Xing, Guang-Qun.,...&Zhao, Ming-Hui.(2011).Modified C-Reactive Protein Might be a Target Autoantigen of TINU Syndrome.CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY,6(1),93-100.
MLA Tan, Ying,et al."Modified C-Reactive Protein Might be a Target Autoantigen of TINU Syndrome".CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY 6.1(2011):93-100.
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