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学科主题临床医学
Hyperhomocysteinemia predicts renal function decline: a prospective study in hypertensive adults
Xie, Di1; Yuan, Yan1; Guo, Jiangnan1; Yang, Shenglin1; Xu, Xin1; Wang, Qin1; Li, Youbao1; Qin, Xianhui1; Tang, Genfu2; Huo, Yong3; Deng, Guangpu1; Wu, Shengjie1; Wang, Binyan1,4; Zhang, Qin1; Wang, Xiaobin5; Fang, Pu6; Wang, Hong6; Xu, Xiping1; Hou, Fanfan1
刊名SCIENTIFIC REPORTS
2015-11-10
DOI10.1038/srep16268
5
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]CHRONIC KIDNEY-DISEASE ; GLOMERULAR-FILTRATION-RATE ; VASCULAR-DISEASE ; FOLIC-ACID ; HOMOCYSTEINE LEVELS ; CARDIOVASCULAR-DISEASE ; BLOOD-PRESSURE ; RISK-FACTOR ; PLASMA HOMOCYSTEINE ; SERUM CREATININE
英文摘要

Hyper-homocysteinemia (HHcy) is associated with microalbuminuria and glomerular injury in general and diabetic populations. However, HHcy′s role in hypertensive patients was not studied. We investigated whether HHcy is an independent risk factor for renal function decline and development of chronic kidney disease (CKD) in hypertensive men and women. This was a community-based prospective cohort study of 2,387 hypertensive adults without CKD at baseline, with a mean follow-up of 4.4 years. Baseline and follow-up levels of plasma Hcy, folate, vitamin B12, blood pressure and other pertinent covariables were obtained. CKD was defined as an estimated glomerular filtration rate (eGFR) < 60 ml/min/per 1.73 m(2) and an eGFR decline rate > 1 ml/min/per 1.73 m(2)/year. There was a graded association between Hcy tertiles and eGFR decline. Subjects in the 3rd tertile of Hcy levels had an accelerated rate of eGFR decline and an increased risk of incident CKD, as compared with those in the 1st tertile, after adjusting for age, gender, baseline diabetes, SBP, BMI, smoking, dyslipidemia, eGFR, folate and vitamin B12 levels. In conclusion, in this prospective cohort of Chinese hypertensive adults, elevated baseline plasma Hcy can serve as an independent biomarker to predict renal function decline and incident CKD.

语种英语
WOS记录号WOS:000364448300001
项目编号2012CB517703 ; 2011BAI10B02 ; 2010U1-E00821 ; 81202280 ; S201204006973
资助机构Major State Basic Research Development Program of China (973 program) ; National Key Technologies RD program ; Major Scientific and Technological Planning Project of Guangzhou City ; National Nature and Science Grant ; PhD Start-up Fund of the Natural Science Foundation of Guangdong Province
引用统计
被引频次:14[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50473
专题北京大学第一临床医学院_心血管内科
作者单位1.Southern Med Univ, Nanfang Hosp, State Key Lab Organ Failure Res, Nat Clin Res Ctr Kidney Dis,Div Nephrol, Guangzhou, Guangdong, Peoples R China
2.Anhui Med Univ, Sch Hlth Adm, Hefei, Peoples R China
3.Peking Univ, Hosp 1, Dept Cardiol, Beijing 100871, Peoples R China
4.Anhui Med Univ, Inst Biomed, Hefei, Peoples R China
5.Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Dept Populat Family & Reprod Hlth, Baltimore, MD USA
6.Temple Univ, Dept Pharmacol, Ctr Metab Dis Res, Sch Med, Philadelphia, PA 19122 USA
推荐引用方式
GB/T 7714
Xie, Di,Yuan, Yan,Guo, Jiangnan,et al. Hyperhomocysteinemia predicts renal function decline: a prospective study in hypertensive adults[J]. SCIENTIFIC REPORTS,2015,5.
APA Xie, Di.,Yuan, Yan.,Guo, Jiangnan.,Yang, Shenglin.,Xu, Xin.,...&Hou, Fanfan.(2015).Hyperhomocysteinemia predicts renal function decline: a prospective study in hypertensive adults.SCIENTIFIC REPORTS,5.
MLA Xie, Di,et al."Hyperhomocysteinemia predicts renal function decline: a prospective study in hypertensive adults".SCIENTIFIC REPORTS 5(2015).
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