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学科主题: 基础医学
题名:
THE ROLE OF STRIATAL NMDA RECEPTORS IN DRUG ADDICTION
作者: Ma, Yao-Ying1; Cepeda, Carlos2; Cui, Cai-Lian3,4; Lu, XH1
刊名: NOVEL APPROACHES TO STUDYING BASAL GANGLIA AND RELATED NEUROPSYCHIATRIC DISODERS
发表日期: 2009
DOI: 10.1016/S0074-7742(09)89006-5
卷: 89, 页:131-146
收录类别: BSCI ; SCI
文章类型: Book Chapter
WOS标题词: Science & Technology
类目[WOS]: Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: D-ASPARTATE RECEPTOR ; SIGNAL-REGULATED KINASE ; SUBUNIT MESSENGER-RNAS ; RAT NUCLEUS-ACCUMBENS ; VENTRAL TEGMENTAL AREA ; GLUTAMATE RECEPTORS ; MOLECULAR-BIOLOGY ; PLACE PREFERENCE ; TYROSINE KINASE ; BASAL GANGLIA
英文摘要:

The past decade has witnessed an impressive accumulation of evidence indicating that the excitatory amino acid glutamate and its receptors, in particular the N-methyl-D-aspartate (NMDA) receptor subtype, play ail important role in drug addiction. Various lines of research using animal models of drug addiction have demonstrated that drug-induced craving is accompanied by significant upregulation of NR2B subunit expression. Furthermore, selective blockade of NR2B-containing NMDA receptors in the striatum, especially in the nucleus accumbens (NAc) call inhibit drug craving and reinstatement. The purpose of this review is to examine the role of striatal NMDA receptors in drug addiction. After a brief description of glutamatergic innervation and NMDA receptor subunit distribution ill the striatum, we discuss potential mechanisms to explain the role of striatal NMDA receptors in drug addiction by elucidating signaling cascades involved in the regulation of subunit expression and redistribution, phosphorylation of receptor subunits, as well as activation of intracellular signals triggered by drug experience. Understanding the mechanisms regulating striatal NMDA receptor changes in drug addiction will provide more specific and rational targets to counteract the deleterious effects of drug addiction.

语种: 英语
WOS记录号: WOS:000272436500007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50477
Appears in Collections:基础医学院_神经生物学系_期刊论文

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作者单位: 1.Peking Univ, Hlth Sci Ctr, Dept Neurobiol, Beijing, Peoples R China
2.Univ Calif Los Angeles, Stefan & Shirley Hatos Ctr Neuropharmacol, Los Angeles, CA 90095 USA
3.Univ Calif Los Angeles, Mental Retardat Res Ctr, Semel Inst Neurosci & Human Behav, Los Angeles, CA 90024 USA
4.Peking Univ, Hlth Sci Ctr, Neurosci Res Inst, Beijing, Peoples R China

Recommended Citation:
Ma, Yao-Ying,Cepeda, Carlos,Cui, Cai-Lian,et al. THE ROLE OF STRIATAL NMDA RECEPTORS IN DRUG ADDICTION[J]. NOVEL APPROACHES TO STUDYING BASAL GANGLIA AND RELATED NEUROPSYCHIATRIC DISODERS,2009,89:131-146.
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