IR@PKUHSC  > 北京大学第一临床医学院  > 肾脏内科
学科主题临床医学
Cellular pathophysiology of ischemic acute kidney injury
Bonventre, Joseph V.1,2; Yang, Li3
刊名JOURNAL OF CLINICAL INVESTIGATION
2011-11-01
DOI10.1172/JCI45161
121期:11页:4210-4221
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, Research & Experimental
研究领域[WOS]Research & Experimental Medicine
关键词[WOS]ACUTE-RENAL-FAILURE ; TUBULAR EPITHELIAL-CELLS ; GELATINASE-ASSOCIATED LIPOCALIN ; INDUCED FUNCTIONAL INJURY ; POSTISCHEMIC RAT-KIDNEY ; MAPK KINASE ACTIVATION ; INNATE IMMUNE-RESPONSE ; MESENCHYMAL STEM-CELLS ; TOLL-LIKE RECEPTORS ; REPERFUSION INJURY
英文摘要

Ischemic kidney injury often occurs in the context of multiple organ failure and sepsis. Here, we review the major components of this dynamic process, which involves hemodynamic alterations, inflammation, and endothelial and epithelial cell injury, followed by repair that can be adaptive and restore epithelial integrity or maladaptive, leading to chronic kidney disease. Better understanding of the cellular pathophysiological processes underlying kidney injury and repair will hopefully result in the design of more targeted therapies to prevent the injury, hasten repair, and minimize chronic progressive kidney disease.

语种英语
WOS记录号WOS:000296482700003
项目编号DK39773 ; DK38452 ; DK72381
资助机构Partners Healthcare ; Johnson Johnson ; BASF ; NIDDK-NIH
引用统计
被引频次:652[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50483
专题北京大学第一临床医学院_肾脏内科
作者单位1.Brigham & Womens Hosp, Div Renal, Boston, MA 02115 USA
2.Harvard Univ, Sch Med, Dept Med, Boston, MA USA
3.Peking Univ, Hosp 1, Div Renal, Beijing 100871, Peoples R China
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GB/T 7714
Bonventre, Joseph V.,Yang, Li. Cellular pathophysiology of ischemic acute kidney injury[J]. JOURNAL OF CLINICAL INVESTIGATION,2011,121(11):4210-4221.
APA Bonventre, Joseph V.,&Yang, Li.(2011).Cellular pathophysiology of ischemic acute kidney injury.JOURNAL OF CLINICAL INVESTIGATION,121(11),4210-4221.
MLA Bonventre, Joseph V.,et al."Cellular pathophysiology of ischemic acute kidney injury".JOURNAL OF CLINICAL INVESTIGATION 121.11(2011):4210-4221.
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