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学科主题临床医学
EGFR mutations are associated with prognosis but not with the response to front-line chemotherapy in the Chinese patients with advanced non-small cell lung cancer
Wu, Meina1; Zhao, Jun1; Song, Sonya Wei3; Zhuo, Minglei1; Wang, Xin1; Bai, Hua1; Wang, Shuhang1; Yang, Lu1; An, Tongtong1; Zhang, Yan2; Duan, Jianchun1; Wang, Yuyan1; Guo, Qingzhi1; Liu, Xuyi1; Liu, Ninghong1; Wang, Jie1
关键词Non-small Cell Lung Cancer Egfr Mutation Front-line Chemotherapy Prognosis Targeted Therapy Gefitinib
刊名LUNG CANCER
2010-03-01
DOI10.1016/j.lungcan.2009.04.011
67期:3页:343-347
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology ; Respiratory System
研究领域[WOS]Oncology ; Respiratory System
关键词[WOS]FACTOR-RECEPTOR MUTATIONS ; PHASE-III TRIAL ; GENE COPY NUMBER ; GEFITINIB ; ERLOTINIB ; THERAPY
英文摘要

The study aimed to investigate associations of tumor tissue EGFR mutations with response to the front-line chemotherapy and prognosis in advanced non-small cell lung cancer (NSCLC) patients EGFR genotypes of 145 chemotherapy-naive patients with Stage IIIB and IV NSCLC were examined by using denaturing high-performance liquid chromatography (DHPLC). All patients received the front-line chemotherapy There were 69 patients who received gefitinib therapy (32 as second-line and 37 as third-line therapy) About 379% (55/145) of the patients was detected to have EGFR mutations in their tumor tissue DNA The response rate (RR, complete response plus partial response) to the chemotherapy for mutated EGFR carriers was 34.5% (19/55), similar to 33 3% (30/90) for wild-type EGFR carriers (P=0 881) The patients with EGFR mutations had increased median survival time and 1- and 2-year survival rate than those with wild-type EGFR (23 vs 16 months, 86 38% vs 62.64%, 38 78% vs 27.16%. P= 0 0273) Among Stage IV NSCLC patients, mutated EGFR carriers had a longer progression-free survival (PFS) than wild-type EGFR carriers (5 vs 3 months, P= 0 040) Cox multivariate regression analysis showed that response to the frontline chemotherapy (RR vs PD) and EGFR mutation were Independent prognostic factors (HR = 0 461,95% CI: 0 271-0 783, P= 00042, HR =0598. 95% CI: 0 372-0 961, P= 00335, respectively) for patients with advanced NSCLC We conclude that EGFR mutations in the Chinese patients with advanced NSCLC were not associated with response to the front-line chemotherapy, but Stage IV NSCLC patients with mutated EGFR had a longer PFS after the front-line chemotherapy. EGFR mutation is an independent prognostic factor for Chinese advanced NSCLC (C) 2009 Elsevier Ireland Ltd All rights reserved

语种英语
WOS记录号WOS:000275776000014
项目编号2006AA02A401 ; 30772472 ; 2-013-39
资助机构National High Technology Research and Development Program of China ; Capital Development Foundation ; Peking University
引用统计
被引频次:39[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50486
专题北京大学临床肿瘤学院_病案统计室
北京大学临床肿瘤学院_胸部肿瘤内科
作者单位1.Peking Univ, Beijing Canc Hosp & Inst, Key Lab Carcinogenesis & Translat Res, Dept Thorac Med Oncol,Sch Oncol,Minist Educ, Beijing 100142, Peoples R China
2.Peking Univ, Beijing Canc Hosp & Inst, Dept Med Stat, Sch Oncol, Beijing 100142, Peoples R China
3.Capital Med Univ, Beijing Shijitan Hosp, Canc Res Lab, Beijing 100038, Peoples R China
推荐引用方式
GB/T 7714
Wu, Meina,Zhao, Jun,Song, Sonya Wei,et al. EGFR mutations are associated with prognosis but not with the response to front-line chemotherapy in the Chinese patients with advanced non-small cell lung cancer[J]. LUNG CANCER,2010,67(3):343-347.
APA Wu, Meina.,Zhao, Jun.,Song, Sonya Wei.,Zhuo, Minglei.,Wang, Xin.,...&Wang, Jie.(2010).EGFR mutations are associated with prognosis but not with the response to front-line chemotherapy in the Chinese patients with advanced non-small cell lung cancer.LUNG CANCER,67(3),343-347.
MLA Wu, Meina,et al."EGFR mutations are associated with prognosis but not with the response to front-line chemotherapy in the Chinese patients with advanced non-small cell lung cancer".LUNG CANCER 67.3(2010):343-347.
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