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Long-term studies on the stability and oral bioavailability of cyclosporine A nanoparticle colloid
Dai, Jun-dong1; Zhang, Tao1; Lu, Wan-liang1; Zhang, Hua1; Zhang, Xuan1; Wang, Jian-cheng1; Zhang, Qiang1; Wang, Xue-qing1; Huang, Jia1
关键词Cyclosporine a Nanoparticles Stability Bioavailability Pharmacokinetics
刊名INTERNATIONAL JOURNAL OF PHARMACEUTICS
2006-09-28
DOI10.1016/j.ijpharm.2006.05.021
322期:1-2页:146-153
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pharmacology & Pharmacy
研究领域[WOS]Pharmacology & Pharmacy
关键词[WOS]PH-SENSITIVE NANOPARTICLES ; PARTICLE-SIZE ; RELEASE RATES ; DOSAGE FORMS ; PHARMACOKINETICS ; MICROSPHERES ; POLYCAPROLACTONE ; NANOSPHERES
英文摘要

The present study was geared at the long-term stability and the changes in oral bioavailability of CyA Eudragit (R) S100 nanoparticles stabilized by suspending agents. CyA Eudragit (R) S100 nanoparticle colloids were prepared by quasi-emulsion solvent diffusion technique and they were mixed with Xanthan gum to obtain suspended nanoparticle colloids. The suspended nanoparticle colloids were preserved at different temperatures for different period of time, as long as 18 months. During the storage period, the CyA concentration, particle size, pH and viscosity were determined. The results indicated that CyA concentration, particle size and viscosity of the colloids had no obvious change. However, the pH increased slightly from 5.5 to about 6.4. The results of bioavailability and pharmacokinetic study revealed that all formulations of nanoparticles showed higher C-max and higher AUC(0-24) values than that of reference (Neoral (R)). The relative bioavailability of S-CyA-S100 NP initial compared with Neoral (R) was 162.8%. The C-max and AUC(0-24) values of nanoparticle formulations at 12 and 18 months were both lower than that of the initial. The bioequivalency was suggested between the tested nanoparticle formulations at the initial and 12 months. It was deduced by surface analysis, TEM observation, in vitro release as well as the characteristics of Eudragit (R) S100 that the decrease in bioavailability might be due to the pH change of the nanoparticle colloid. (c) 2006 Elsevier B.V. All rights reserved.

语种英语
WOS记录号WOS:000241081100019
Citation statistics
Cited Times:6[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50488
Collection北京大学药学院
作者单位1.Peking Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, Beijing 100083, Peoples R China
2.Peking Univ, Hlth Sci Ctr, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China
3.N China Pharmaceut Grp, New Drugs R&D Ctr, Shijiazhuang 050015, Peoples R China
Recommended Citation
GB/T 7714
Dai, Jun-dong,Zhang, Tao,Lu, Wan-liang,et al. Long-term studies on the stability and oral bioavailability of cyclosporine A nanoparticle colloid[J]. INTERNATIONAL JOURNAL OF PHARMACEUTICS,2006,322(1-2):146-153.
APA Dai, Jun-dong.,Zhang, Tao.,Lu, Wan-liang.,Zhang, Hua.,Zhang, Xuan.,...&Huang, Jia.(2006).Long-term studies on the stability and oral bioavailability of cyclosporine A nanoparticle colloid.INTERNATIONAL JOURNAL OF PHARMACEUTICS,322(1-2),146-153.
MLA Dai, Jun-dong,et al."Long-term studies on the stability and oral bioavailability of cyclosporine A nanoparticle colloid".INTERNATIONAL JOURNAL OF PHARMACEUTICS 322.1-2(2006):146-153.
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