学科主题 | 药学 |
Long-term studies on the stability and oral bioavailability of cyclosporine A nanoparticle colloid | |
Dai, Jun-dong1; Zhang, Tao1; Lu, Wan-liang1; Zhang, Hua1; Zhang, Xuan1; Wang, Jian-cheng1; Zhang, Qiang1; Wang, Xue-qing1; Huang, Jia1 | |
关键词 | Cyclosporine a Nanoparticles Stability Bioavailability Pharmacokinetics |
刊名 | INTERNATIONAL JOURNAL OF PHARMACEUTICS
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2006-09-28 | |
DOI | 10.1016/j.ijpharm.2006.05.021 |
卷 | 322期:1-2页:146-153 |
收录类别 | SCI |
文章类型 | Article |
WOS标题词 | Science & Technology |
类目[WOS] | Pharmacology & Pharmacy |
研究领域[WOS] | Pharmacology & Pharmacy |
关键词[WOS] | PH-SENSITIVE NANOPARTICLES ; PARTICLE-SIZE ; RELEASE RATES ; DOSAGE FORMS ; PHARMACOKINETICS ; MICROSPHERES ; POLYCAPROLACTONE ; NANOSPHERES |
英文摘要 | The present study was geared at the long-term stability and the changes in oral bioavailability of CyA Eudragit (R) S100 nanoparticles stabilized by suspending agents. CyA Eudragit (R) S100 nanoparticle colloids were prepared by quasi-emulsion solvent diffusion technique and they were mixed with Xanthan gum to obtain suspended nanoparticle colloids. The suspended nanoparticle colloids were preserved at different temperatures for different period of time, as long as 18 months. During the storage period, the CyA concentration, particle size, pH and viscosity were determined. The results indicated that CyA concentration, particle size and viscosity of the colloids had no obvious change. However, the pH increased slightly from 5.5 to about 6.4. The results of bioavailability and pharmacokinetic study revealed that all formulations of nanoparticles showed higher C-max and higher AUC(0-24) values than that of reference (Neoral (R)). The relative bioavailability of S-CyA-S100 NP initial compared with Neoral (R) was 162.8%. The C-max and AUC(0-24) values of nanoparticle formulations at 12 and 18 months were both lower than that of the initial. The bioequivalency was suggested between the tested nanoparticle formulations at the initial and 12 months. It was deduced by surface analysis, TEM observation, in vitro release as well as the characteristics of Eudragit (R) S100 that the decrease in bioavailability might be due to the pH change of the nanoparticle colloid. (c) 2006 Elsevier B.V. All rights reserved. |
语种 | 英语 |
WOS记录号 | WOS:000241081100019 |
Citation statistics | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.bjmu.edu.cn/handle/400002259/50488 |
Collection | 北京大学药学院 |
作者单位 | 1.Peking Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, Beijing 100083, Peoples R China 2.Peking Univ, Hlth Sci Ctr, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China 3.N China Pharmaceut Grp, New Drugs R&D Ctr, Shijiazhuang 050015, Peoples R China |
Recommended Citation GB/T 7714 | Dai, Jun-dong,Zhang, Tao,Lu, Wan-liang,et al. Long-term studies on the stability and oral bioavailability of cyclosporine A nanoparticle colloid[J]. INTERNATIONAL JOURNAL OF PHARMACEUTICS,2006,322(1-2):146-153. |
APA | Dai, Jun-dong.,Zhang, Tao.,Lu, Wan-liang.,Zhang, Hua.,Zhang, Xuan.,...&Huang, Jia.(2006).Long-term studies on the stability and oral bioavailability of cyclosporine A nanoparticle colloid.INTERNATIONAL JOURNAL OF PHARMACEUTICS,322(1-2),146-153. |
MLA | Dai, Jun-dong,et al."Long-term studies on the stability and oral bioavailability of cyclosporine A nanoparticle colloid".INTERNATIONAL JOURNAL OF PHARMACEUTICS 322.1-2(2006):146-153. |
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