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学科主题: 临床医学
题名:
Different post label delay cerebral blood flow measurements in patients with Alzheimer′s disease using 3D arterial spin labeling
作者: Liu, Ying1; Zeng, Xiangzhu1; Wang, Zheng1; Zhang, Na2; Fan, Dongsheng2; Yuan, Huishu1
关键词: Alzheimer&prime ; s disease ; Arterial spin labeling (ASL) ; Cerebral blood flow ; Post label delay
刊名: MAGNETIC RESONANCE IMAGING
发表日期: 2015-11-01
DOI: 10.1016/j.mri.2015.05.001
卷: 33, 期:9, 页:1019-1025
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Radiology, Nuclear Medicine & Medical Imaging
研究领域[WOS]: Radiology, Nuclear Medicine & Medical Imaging
关键词[WOS]: MILD COGNITIVE IMPAIRMENT ; POSITRON-EMISSION-TOMOGRAPHY ; PERFUSION MRI ; INITIAL-EXPERIENCE ; TRANSIT-TIME ; RELIABILITY ; BRAIN ; PET ; REPRODUCIBILITY ; HYPOPERFUSION
英文摘要:

Purpose: To evaluate cerebral blood flow (CBF) in patients with Alzheimer′s disease (AD) using a three-dimensional pseudocontinuous arterial spin labeling (PCASL). We aimed to study the effects of different post label delay on the resulting CBF maps and to investigate the characteristics and clinical applications of brain perfusion.

Materials and methods: Sixteen AD patients and nineteen healthy control subjects were recruited. 3D PCASL was performed using a 3.0 TMR scanner. ASL was performed twice with different post label delays (PLD). Comparisons of CBF were made between AD patients and healthy control subjects respectively with PLD of 1.5 s and PLO of 2.5 s. Relationship between the CBF values and cognition was investigated using correlation analysis. A receiver operating characteristic (ROC) curve was generated for CBF measurements in posterior cingulate region.

Result: AD patients with PLD of 1.5 s showed lower CBF values primarily in bilateral temporal lobes, precuneus, middle and posterior cingulate gyri, left inferior parietal gyrus, left angular gyrus and left superior frontal gyrus. Lowered cerebral values were also observed in similar regions with PLD of 2.5 s, but the clusters of voxel were smaller. CBF values were associated with cognition scores in most of gyri mentioned above.

Conclusion: Hypoperfusion areas were observed in AD patients. PLO of 1.5 s was sufficient to display CBF. Considering the complicated AD pathology, multiple PLDs are strongly recommended. (C) 2015 Elsevier Inc. All rights reserved.

语种: 英语
WOS记录号: WOS:000363831200001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50494
Appears in Collections:北京大学第三临床医学院_放射科_期刊论文

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作者单位: 1.Peking Univ, Dept Radiol, Hosp 3, Beijing 100871, Peoples R China
2.Peking Univ, Dept Neurol, Hosp 3, Beijing 100871, Peoples R China

Recommended Citation:
Liu, Ying,Zeng, Xiangzhu,Wang, Zheng,et al. Different post label delay cerebral blood flow measurements in patients with Alzheimer′s disease using 3D arterial spin labeling[J]. MAGNETIC RESONANCE IMAGING,2015,33(9):1019-1025.
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