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学科主题基础医学
The biomarker N-terminal pro-brain natriuretic peptide and liver diseases
Wang, Ling1; Geng, Jiabao1,3; Li, Jie1; Li, Tong1; Matsumori, Akira2; Chang, Yibin1; Lu, Fengmin1; Zhuang, Hui1
刊名CLINICAL AND INVESTIGATIVE MEDICINE
2011
34期:1页:E30-E37
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, Research & Experimental
研究领域[WOS]Research & Experimental Medicine
关键词[WOS]LEFT-VENTRICULAR DYSFUNCTION ; ACUTE PULMONARY-EMBOLISM ; HEART-FAILURE ; SYSTOLIC DYSFUNCTION ; PROGNOSTIC ROLE ; CHILDREN ; INFANTS ; SECRETION ; MORTALITY ; MARKER
英文摘要

Purpose: NT-proBNP has emerged as a powerful diagnostic and prognostic biomarker in heart disease. Studies showed that NT-proBNP is a sensitive biomarker for identifying patients with heart failure caused by hepatitis C virus (HCV) related myocarditis. The purpose of this study was to evaluate the correlation between the serum concentration of NT-proBNP and hepatitis virus infection/liver disease.

Methods: 223 serum samples from blood donors (aged 19 similar to 50 years old) were collected as a control group, and 644 samples were obtained from patients infected by hepatitis viruses including 493 HBV: 364 chronic hepatitis (CH), 86 hepatocellular carcinoma (HCC) and 43 liver cirrhosis (LC) and 151 HCV (85 CH, 14 HCC, 52 LC). All samples were assayed with an Elecsys immunoassay analyzer for NT-proBNP concentration.

Results: The mean concentration of NT-proBNP in the control group was 21.77 pg/ml and showed no significant variation with either age or gender. Both the mean value and the rate of abnormality of NT-proBNP were significantly higher for the HBV-and HCV-infected groups in comparison with the control group. The mean NT-proBNP value (380.24 pg/ml) and abnormality rate (38.41%) in the HCV group were higher than that of the HBV group. For samples from patients with HBV/HCV-related hepatic disease/pathology, the mean NT-proBNP value (517.19 pg/ml/597.18 pg/ml) were the highest in the liver cirrhosis group.

Conclusions: Hepatic pathologic lesions, particularly cirrhosis, may contribute to the elevation of NT-proBNP in subjects with HBV/HCV infection.

语种英语
WOS记录号WOS:000287413600005
项目编号30771996 ; 2008ZX10002-012 ; 2008ZX10002-013
资助机构National Science Foundation of China ; Ministry of Science and Technology of China
引用统计
被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50498
专题北京大学基础医学院_病原生物学系
北京大学基础医学院
作者单位1.Peking Univ, Hlth Sci Ctr, Dept Microbiol, Beijing 100191, Peoples R China
2.Kyoto Univ, Dept Cardiovasc Med, Kyoto 6068501, Japan
3.81st Hosp PLA, Inst Hepatol, Nanjing, Jiangsu Prov, Peoples R China
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GB/T 7714
Wang, Ling,Geng, Jiabao,Li, Jie,et al. The biomarker N-terminal pro-brain natriuretic peptide and liver diseases[J]. CLINICAL AND INVESTIGATIVE MEDICINE,2011,34(1):E30-E37.
APA Wang, Ling.,Geng, Jiabao.,Li, Jie.,Li, Tong.,Matsumori, Akira.,...&Zhuang, Hui.(2011).The biomarker N-terminal pro-brain natriuretic peptide and liver diseases.CLINICAL AND INVESTIGATIVE MEDICINE,34(1),E30-E37.
MLA Wang, Ling,et al."The biomarker N-terminal pro-brain natriuretic peptide and liver diseases".CLINICAL AND INVESTIGATIVE MEDICINE 34.1(2011):E30-E37.
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