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学科主题: 基础医学
题名:
HLA-A*02:07 Is a Protective Allele for EBV Negative and a Susceptibility Allele for EBV Positive Classical Hodgkin Lymphoma in China
作者: Huang, Xin1,2; Hepkema, Bouke3; Nolte, Ilja4; Kushekhar, Kushi1; Jongsma, Theo3; Veenstra, Rianne1; Poppema, Sibrand1; Gao, Zifen2; Visser, Lydia1; Diepstra, Arjan1; van den Berg, Anke1
刊名: PLOS ONE
发表日期: 2012-02-15
DOI: 10.1371/journal.pone.0031865
卷: 7, 期:2
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: EPSTEIN-BARR-VIRUS ; HLA CLASS-I ; NASOPHARYNGEAL CARCINOMA ; INFECTIOUS-MONONUCLEOSIS ; T-LYMPHOCYTES ; EPITOPES ; IDENTIFICATION ; RESPONSES ; PEPTIDES ; DISEASE
英文摘要:

HLA-A2 protects from EBV+ classical Hodgkin lymphoma (cHL) in Western Europe, but it is unknown whether this protective effect also exists in the Chinese population. We investigated the association of HLA-A2 and specific common and well documented HLA-A2 subtypes with EBV stratified cHL patients (n = 161) from the northern part of China. Quantitative-PCR and sequence-based subtyping was performed to identify HLA-A2 positive samples and their subtypes. 67 (42%) of the cHL patients were EBV+. There were no significant differences in percentages of HLA-A2 positivity between cHL and controls (65% vs 66%) and between EBV+ and EBV- cHL patients (70% vs 61%). The frequency distribution of HLA-A2 subtypes was significantly different between EBV stratified cHL subgroups and controls. This difference was most striking for the HLAA*02:07 type with a frequency of 38% in EBV+ cHL, 8% in EBV- cHL and 20% in controls. Significant differences were also observed for the HLA-A*02:07, HLA-A2 (non-02:07) and the A2-negative typings between EBV+ cHL vs controls (p = 0.028), EBV- cHL vs controls (p = 0.045) and EBV+ vs EBV- cHL cases (p = 2 x 10(-5)). In conclusion, HLA-A*02: 07 is a predisposing allele for EBV+ cHL and a protective allele for EBV- cHL in the northern Chinese population.

语种: 英语
所属项目编号: KWF: RUG 2009-4313
项目资助者: University Medical Center Groningen ; Dutch Cancer Society
WOS记录号: WOS:000302741300100
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50499
Appears in Collections:基础医学院_病理学系_期刊论文

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作者单位: 1.Univ Groningen, Dept Pathol & Med Biol, Univ Med Ctr Groningen, Groningen, Netherlands
2.Peking Univ, Dept Pathol, Hlth Sci Ctr, Beijing 100871, Peoples R China
3.Univ Groningen, Dept Lab Med, Univ Med Ctr Groningen, Groningen, Netherlands
4.Univ Groningen, Unit Genet Epidemiol & Bioinformat, Univ Med Ctr Groningen, Dept Epidemiol, Groningen, Netherlands

Recommended Citation:
Huang, Xin,Hepkema, Bouke,Nolte, Ilja,et al. HLA-A*02:07 Is a Protective Allele for EBV Negative and a Susceptibility Allele for EBV Positive Classical Hodgkin Lymphoma in China[J]. PLOS ONE,2012,7(2).
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