IR@PKUHSC  > 中国药物依赖性研究所
学科主题药物依赖
Buspirone-induced antinociception is mediated by L-type calcium channels and calcium/caffeine-sensitive pools in mice
Liang, JH; Wang, XH; Liu, RK; Sun, HL; Ye, XF; Zheng, JW
关键词Buspirone Fluoxetine Calcium Channel Blocker Ryanodine Nociception The Hot-plate Test
刊名PSYCHOPHARMACOLOGY
2003-03-01
DOI10.1007/s00213-002-1327-4
166期:3页:276-283
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences ; Pharmacology & Pharmacy ; Psychiatry
研究领域[WOS]Neurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry
关键词[WOS]RAT SPINAL-CORD ; N-TYPE ; DIVALENT-CATIONS ; 5-HT1A RECEPTORS ; CHOLINERGIC ANTINOCICEPTION ; SEROTONERGIC INHIBITION ; MORPHINE ANALGESIA ; SENSORY NEURONS ; XENOPUS LARVAE ; RAPHE NEURONS
英文摘要

Rationale: Previous studies have shown that buspirone, a partial 5-HT1A receptor agonist, produces antinociceptive effects in rats and mice; Ca2+ plays a critical role as a second messenger in mediating nociceptive transmission. 5-HT1A receptors have been proven to be coupled functionally with various types of Ca2+ channels in neurons, including N-, P/Q-, T-, or L-type. It was of interest to investigate the involvement of extracellular/intracellular Ca2+ in buspirone-induced antinociception. Objectives: To determine whether central serotonergic pathways participate in the antinociceptive processes of buspirone, and investigate the involvement of Ca2+ mechanisms, particularly L-voltage-gated Ca2+ channels and Ca2+/caffeine-sensitive pools, in buspironeinduced antinociception. Methods: Antinociception was assessed using the hot-plate test (55degreesC, hind-paw licking latency) in mice treated with either buspirone (1.25-20 mg/kg i.p.) alone or the combination of buspirone and fluoxetine (2.5-10 mg/kg i.p.), 5-HTP (25 mg/kg i.p.), nimodipine (2.5-10 mg/kg i.p.), nifedipine (2.5-10 mg/kg i.p.), CaCl2 (25-200 nmol per mouse i.c.v.), EGTA (530 nmol per mouse i.c.v.), or ryanodine (0.25-2 nmol per mouse i.c.v.). Results: Buspirone dose dependently increased the licking latency in the hot-plate test in mice. This effect of buspirone was enhanced by fluoxetine, 5-HTP, nimodipine, and nifedipine. Interestingly, central administration of Ca2+ reversed the antinociceptive effects of buspirone. In contrast to these, ryanodine or EGTA administered centrally potentiated buspirone-induced antinociception. Conclusions Decreasing neuronal Ca2+ levels potentiated buspirone-induced antinociception; conversely, increasing intracellular Ca2+ abolished the antinociceptive effects of buspirone. These results suggest that Ca2+ influx from extracellular fluid and release of Ca2+ from Ca2+/caffeine- sensitive microsomal pools may be involved in buspirone-induced antinociception.

语种英语
WOS记录号WOS:000182202000012
Citation statistics
Cited Times:9[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50505
Collection中国药物依赖性研究所
作者单位Peking Univ, Natl Inst Drug Dependence, Dept Neuropharmacol, Beijing 100083, Peoples R China
Recommended Citation
GB/T 7714
Liang, JH,Wang, XH,Liu, RK,et al. Buspirone-induced antinociception is mediated by L-type calcium channels and calcium/caffeine-sensitive pools in mice[J]. PSYCHOPHARMACOLOGY,2003,166(3):276-283.
APA Liang, JH,Wang, XH,Liu, RK,Sun, HL,Ye, XF,&Zheng, JW.(2003).Buspirone-induced antinociception is mediated by L-type calcium channels and calcium/caffeine-sensitive pools in mice.PSYCHOPHARMACOLOGY,166(3),276-283.
MLA Liang, JH,et al."Buspirone-induced antinociception is mediated by L-type calcium channels and calcium/caffeine-sensitive pools in mice".PSYCHOPHARMACOLOGY 166.3(2003):276-283.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
谷歌学术
谷歌学术Similar articles in
[Liang, JH]'s Articles
[Wang, XH]'s Articles
[Liu, RK]'s Articles
百度学术
百度学术Similar articles in
[Liang, JH]'s Articles
[Wang, XH]'s Articles
[Liu, RK]'s Articles
必应学术
必应学术Similar articles in
[Liang, JH]'s Articles
[Wang, XH]'s Articles
[Liu, RK]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.