学科主题 | 药物依赖 |
Buspirone-induced antinociception is mediated by L-type calcium channels and calcium/caffeine-sensitive pools in mice | |
Liang, JH; Wang, XH; Liu, RK; Sun, HL; Ye, XF; Zheng, JW | |
关键词 | Buspirone Fluoxetine Calcium Channel Blocker Ryanodine Nociception The Hot-plate Test |
刊名 | PSYCHOPHARMACOLOGY
![]() |
2003-03-01 | |
DOI | 10.1007/s00213-002-1327-4 |
卷 | 166期:3页:276-283 |
收录类别 | SCI |
文章类型 | Article |
WOS标题词 | Science & Technology |
类目[WOS] | Neurosciences ; Pharmacology & Pharmacy ; Psychiatry |
研究领域[WOS] | Neurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry |
关键词[WOS] | RAT SPINAL-CORD ; N-TYPE ; DIVALENT-CATIONS ; 5-HT1A RECEPTORS ; CHOLINERGIC ANTINOCICEPTION ; SEROTONERGIC INHIBITION ; MORPHINE ANALGESIA ; SENSORY NEURONS ; XENOPUS LARVAE ; RAPHE NEURONS |
英文摘要 | Rationale: Previous studies have shown that buspirone, a partial 5-HT1A receptor agonist, produces antinociceptive effects in rats and mice; Ca2+ plays a critical role as a second messenger in mediating nociceptive transmission. 5-HT1A receptors have been proven to be coupled functionally with various types of Ca2+ channels in neurons, including N-, P/Q-, T-, or L-type. It was of interest to investigate the involvement of extracellular/intracellular Ca2+ in buspirone-induced antinociception. Objectives: To determine whether central serotonergic pathways participate in the antinociceptive processes of buspirone, and investigate the involvement of Ca2+ mechanisms, particularly L-voltage-gated Ca2+ channels and Ca2+/caffeine-sensitive pools, in buspironeinduced antinociception. Methods: Antinociception was assessed using the hot-plate test (55degreesC, hind-paw licking latency) in mice treated with either buspirone (1.25-20 mg/kg i.p.) alone or the combination of buspirone and fluoxetine (2.5-10 mg/kg i.p.), 5-HTP (25 mg/kg i.p.), nimodipine (2.5-10 mg/kg i.p.), nifedipine (2.5-10 mg/kg i.p.), CaCl2 (25-200 nmol per mouse i.c.v.), EGTA (530 nmol per mouse i.c.v.), or ryanodine (0.25-2 nmol per mouse i.c.v.). Results: Buspirone dose dependently increased the licking latency in the hot-plate test in mice. This effect of buspirone was enhanced by fluoxetine, 5-HTP, nimodipine, and nifedipine. Interestingly, central administration of Ca2+ reversed the antinociceptive effects of buspirone. In contrast to these, ryanodine or EGTA administered centrally potentiated buspirone-induced antinociception. Conclusions Decreasing neuronal Ca2+ levels potentiated buspirone-induced antinociception; conversely, increasing intracellular Ca2+ abolished the antinociceptive effects of buspirone. These results suggest that Ca2+ influx from extracellular fluid and release of Ca2+ from Ca2+/caffeine- sensitive microsomal pools may be involved in buspirone-induced antinociception. |
语种 | 英语 |
WOS记录号 | WOS:000182202000012 |
Citation statistics | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.bjmu.edu.cn/handle/400002259/50505 |
Collection | 中国药物依赖性研究所 |
作者单位 | Peking Univ, Natl Inst Drug Dependence, Dept Neuropharmacol, Beijing 100083, Peoples R China |
Recommended Citation GB/T 7714 | Liang, JH,Wang, XH,Liu, RK,et al. Buspirone-induced antinociception is mediated by L-type calcium channels and calcium/caffeine-sensitive pools in mice[J]. PSYCHOPHARMACOLOGY,2003,166(3):276-283. |
APA | Liang, JH,Wang, XH,Liu, RK,Sun, HL,Ye, XF,&Zheng, JW.(2003).Buspirone-induced antinociception is mediated by L-type calcium channels and calcium/caffeine-sensitive pools in mice.PSYCHOPHARMACOLOGY,166(3),276-283. |
MLA | Liang, JH,et al."Buspirone-induced antinociception is mediated by L-type calcium channels and calcium/caffeine-sensitive pools in mice".PSYCHOPHARMACOLOGY 166.3(2003):276-283. |
Files in This Item: | There are no files associated with this item. |
Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.
Edit Comment