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学科主题: 口腔医学
题名:
Dissecting the Akt/Mammalian target of rapamycin signaling network: Emerging results from the head and neck cancer tissue array initiative
作者: Molinolo, Alfredo A.1; Hewitt, Stephen M.1; Amornphimoltham, Panomwat1; Keelawat, Somboon1; Rangdaeng, Samraeung1; Garcia, Abelardo Meneses1; Raimondi, Ana R.1; Jufe, Rafael1; Itoiz, Maria1; Gao, Yan1; Saranath, Dhananjaya1; Kaleebi, George S.1; Yoo, George H.1; Leak, Lee1; Myers, Ernest M.1; Shintan, Satoru1; Wong, David1; Massey, H. Davis1; Yeudall, W. Andrew1; Lonardo, Fulvio1; Ensley, John1; Gutkind, J. Silvio1
刊名: CLINICAL CANCER RESEARCH
发表日期: 2007-09-01
DOI: 10.1158/1078-0432.CCR-07-1041
卷: 13, 期:17, 页:4964-4973
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: SQUAMOUS-CELL CARCINOMA ; GROWTH-FACTOR RECEPTOR ; IN-SITU HYBRIDIZATION ; THERAPEUTIC TARGET ; CIGARETTE-SMOKING ; MOLECULAR TARGET ; PROGNOSTIC VALUE ; P53 MUTATIONS ; TONGUE CANCER ; ORAL-CANCER
英文摘要:

Purpose: As an approach to evaluate the expression pattern and status of activation of signaling pathways in clinical specimens from head and neck squamous cell carcinoma (HNSCC) patients, we established the Head and Neck Cancer Tissue Array Initiative, an international consortium aimed at developing a high-density HNSCC tissue microarray, with a high representation of oral squamous cell carcinoma.

Experimental Design: These tissue arrays were constructed by acquiring cylindrical biopsies from multiple individual tumor tissues and transferring them into tissue microarray blocks. From a total of 1,300 cases, 547 cores, including controls, were selected and used to build the array.

Results: Emerging information by the use of phosphospecific antibodies detecting the activated state of signaling molecules indicates that the Akt-mammalian target of rapamycin (mTOR) pathway is frequently activated in HNSCC, but independently from the activation of epidermal growth factor receptor or the detection of mutant p53. Indeed, we identified a large group of tissue samples displaying active Akt and mTOR in the absence of epidermal growth factor receptor activation. Furthermore, we have also identified a small subgroup of patients in which the mTOR pathway is activated but not Akt, suggesting the existence of an Akt-independent signaling route stimulating mTOR.

Conclusions: These findings provide important information about the nature of the dysregulated signaling networks in HNSCC and may also provide the rationale for the future development of novel mechanism-based therapies for HNSCC patients.

语种: 英语
WOS记录号: WOS:000249287700006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50509
Appears in Collections:北京大学口腔医学院_口腔病理科_期刊论文

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作者单位: 1.Natl Inst Dent & Craniofacial Res, Oral & Pharyngeal Canc Branch, NIH, Bethesda, MD 20892 USA
2.NCI, Tissue Array Res Program, Pathol Lab, Ctr Canc Res,NIH, Bethesda, MD 20892 USA
3.Chulalongkorn Univ, Fac Med, Dept Pathol, Bangkok 10330, Thailand
4.Chiang Mai Univ, Fac Med, Dept Pathol, Chieng Mai, Thailand
5.Inst Nacl Cancerol, Mexico City, DF, Mexico
6.Univ Buenos Aires, Sch Dent, Lab Patol, Buenos Aires, DF, Argentina
7.Univ Buenos Aires, Sch Dent, Dept Pathol, Buenos Aires, DF, Argentina
8.Peking Univ, Sch Stomatol, Dept Oral Pathol, Beijing 100871, Peoples R China
9.Reliance Ind Ltd, Bombay, Maharashtra, India
10.MEDUNSA, Limpopo, South Africa
11.Wayne State Univ, Dept Otolaryngol Head & Neck Surg & Oncol, Detroit, MI USA
12.Howard Univ, Coll Med, Washington, DC 20059 USA
13.Ehime Univ, Sch Med, Matsuyama, Ehime 790, Japan
14.Univ Calif Los Angeles, Sch Dent, Los Angeles, CA 90024 USA
15.Virginia Commonwealth Univ, Phillips Inst Oral & Cranofacial Mol Biol, Richmond, VA USA

Recommended Citation:
Molinolo, Alfredo A.,Hewitt, Stephen M.,Amornphimoltham, Panomwat,et al. Dissecting the Akt/Mammalian target of rapamycin signaling network: Emerging results from the head and neck cancer tissue array initiative[J]. CLINICAL CANCER RESEARCH,2007,13(17):4964-4973.
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