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学科主题: 临床医学
题名:
Sex Difference in the Prevalence of Left Ventricular Hypertrophy in Dialysis Patients
作者: Cheng, Li-Tao1; Gao, Yan-Li1,3; Tian, Jun-Ping1,2; Gu, Yue1; Zhang, Li1; Bi, Shu-Hong1; Tang, Wen1; Lindholm, Bengt4; Wang, Tao1
关键词: Comorbidity ; Diabetes ; Hemodialysis ; Hypertension, uncontrolled ; Left ventricular hypertrophy ; Left ventricular mass index ; Peritoneal dialysis
刊名: AMERICAN JOURNAL OF NEPHROLOGY
发表日期: 2009
DOI: 10.1159/000171378
卷: 29, 期:5
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Urology & Nephrology
研究领域[WOS]: Urology & Nephrology
关键词[WOS]: STAGE RENAL-DISEASE ; AMBULATORY PERITONEAL-DIALYSIS ; LONG-TERM CAPD ; HEMODIALYSIS-PATIENTS ; CARDIOVASCULAR RISK ; BLOOD-PRESSURE ; UNITED-STATES ; MASS ; WOMEN ; GENDER
英文摘要:

Background: Left ventricular hypertrophy (LVH) is an important, independent negative predictor of cardiovascular morbidity and mortality in the general population and in dialysis patients. Previous studies suggest a sex dimorphism in the prevalence of LVH; however, this issue has never been approached in dialysis patients. Methods: This study enrolled 237 prevalent dialysis patients: 49 on hemodialysis (HD) and 188 on peritoneal dialysis (PD) from a single center. LVH was defined by echocardiography measurements, which were normalized to body surface area (BSA) and height(2.7), respectively. Results: The mean ages in HD and PD patients were 60 +/- 14 and 60 +/- 13 years, with a median dialysis vintage of 43 and 20 months, respectively. Although there was no significant difference in age, diabetes, proportion of uncontrolled hypertension, antihypertensive medication and blood pressure between male and female patients within each dialysis modality, the prevalence of LVH (whether indexed to BSA or height(2.7)) was consistently higher in females than in males. When these patients were divided into LVH or non-LVH groups, a significant difference in sex distribution was observed between the two groups (62.0% vs. 41.0% when the BSA-indexed standard was used, p < 0.01; 62.8% vs. 37.1% when the height(2.7)-indexed standard was used, p < 0.001). In logistic regression analysis, female sex was identified as a risk factor of LVH (odds ratio, OR = 2.48, 95% confidence interval, Cl = 1.33-4.59; when BSA-indexed LVH was treated as dependent variable, and OR = 4.05, 95% Cl = 1.96-8.38, when height(2.7)-indexed LVH was treated as dependent variable) even after adjustment for age, diabetes, blood pressure and antihypertensive medication. Conclusion: This study showed that the prevalence of LVH determined by echocardiography was significantly higher in female dialysis patients than in male dialysis patients. Compared with males, female patients had a 2.5- to 4-fold higher risk to develop LVH even after adjustment for other potential confounding factors, which may indicate that elderly females in the uremic scenario are more prone to develop LVH than elderly males. Copyright (c) 2008 S. Karger AG, Basel

语种: 英语
所属项目编号: 36-1
项目资助者: Ministry of Education ; People&prime ; s Republic of China
WOS记录号: WOS:000264870200008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50512
Appears in Collections:北京大学第三临床医学院_肾内科_期刊论文

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作者单位: 1.Peking Univ, Hosp 3, Div Nephrol, Beijing 100083, Peoples R China
2.Capital Med Univ, Beijing Tiantan Hosp, Div Cardiol, Beijing, Peoples R China
3.Guangzhou Univ Tradit Chinese Med, Clin Coll 2, Div Cardiol, Guangzhou, Guangdong, Peoples R China
4.Karolinska Inst, Dept Clin Sci, Div Baxter Novum & Renal Med, Stockholm, Sweden

Recommended Citation:
Cheng, Li-Tao,Gao, Yan-Li,Tian, Jun-Ping,et al. Sex Difference in the Prevalence of Left Ventricular Hypertrophy in Dialysis Patients[J]. AMERICAN JOURNAL OF NEPHROLOGY,2009,29(5).
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