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学科主题: 临床医学
题名:
Relationship between myocardial ultrasonic integrated backscatter and mitochondria of the myocardium in dogs
作者: Gong, Lin1; Wang, Zhi Gang1; Ran, Hai Tao1; Ling, Zhi Yu1; Tang, Hai Ling1; Zheng, Yuan Yi1; Xu, Chuan Shan1; Zhang, Qun Xia1; Pu, Shi Yu1
关键词: ultrasound ; ultrasonic integrated backscatter ; myocardium ; mitochondria ; stereological analysis
刊名: CLINICAL IMAGING
发表日期: 2006-11-01
DOI: 10.1016/j.clinimag.2006.08.021
卷: 30, 期:6, 页:402-408
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Radiology, Nuclear Medicine & Medical Imaging
研究领域[WOS]: Radiology, Nuclear Medicine & Medical Imaging
关键词[WOS]: LEFT-VENTRICULAR DYSFUNCTION ; CORONARY-ARTERY-DISEASE ; TISSUE CHARACTERIZATION ; CYCLIC VARIATION ; CONTRACTILE RESERVE ; WALL THICKNESS ; VIABILITY ; CARDIOMYOPATHY ; INFARCTION ; ISCHEMIA
英文摘要:

Objective: This study aimed to explore the relationship between integrated backscatter (IBS) and mitochondria in arrested myocardium. Methods: Twelve open-chest dogs were randomly divided into two groups: one group with cardiac arrest in systole and the other with cardiac arrest in diastole. IBS images at parasternal papillary muscle short-axis view were stored at different time frames (0, 30, and 60 min after cardiac arrest). The values of ultrasonic IBS were obtained using the acoustic densitometry technique. After ultrasound examination, tissue samples of corresponding times were harvested and observed under the transmission electron microscope. The microscopic images were analyzed using a computer imaging analysis system to obtain the stereological parameters of mitochondria. The correlation between IBS and the stereological parameters was analyzed. Results: After cardiac arrest, swollen mitochondria with electron-lucent matrix could be observed in some myofibers following the progression of time. The alteration of IBS correlated well with that of mitochondrial stereological parameters, such as volume density (Vv), surface density (Sv), average volume ((nu) over bar), average surface area ((s) over bar), and specific surface (Rsv, ratio between surface and volume). Conclusion: Mitochondria might be an important scatterer in the myocardium for IBS. (C) 2006 Elsevier Inc. All rights reserved.

语种: 英语
WOS记录号: WOS:000242424100005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50515
Appears in Collections:北京大学深圳医院_期刊论文

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作者单位: 1.Chongqing Univ Med Sci, Affiliated Hosp 2, Inst Ultrason Image, Dept Ultrasound, Chongqing 400010, Peoples R China
2.Peking Univ, Shenzhen Hosp, Dept Ultrasound Med, Shenzhen 518036, Peoples R China

Recommended Citation:
Gong, Lin,Wang, Zhi Gang,Ran, Hai Tao,et al. Relationship between myocardial ultrasonic integrated backscatter and mitochondria of the myocardium in dogs[J]. CLINICAL IMAGING,2006,30(6):402-408.
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