IR@PKUHSC  > 北京大学第一临床医学院  > 肾脏内科
学科主题临床医学
Prediction of two-sample Tc-99m-diethylene triamine pentaacetic acid plasma clearance from single-sample method
Zuo, L1; Ma, YC1; Wang, M1; Zhang, CL1; Wang, RF1; Wang, HY1
关键词Glomerular Filtration Rate Tc-99m-dtpa Plasma Clearance Single Plasma Sample Method Dual Plasma Sample Method
刊名ANNALS OF NUCLEAR MEDICINE
2005-07-01
19期:5页:399-405
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Radiology, Nuclear Medicine & Medical Imaging
研究领域[WOS]Radiology, Nuclear Medicine & Medical Imaging
关键词[WOS]GLOMERULAR-FILTRATION-RATE ; CHRONIC KIDNEY-DISEASE ; SERUM CREATININE ; RENAL CLEARANCE ; TC-99M-DTPA ; INULIN ; EQUATIONS ; ACID ; GFR
英文摘要

Objectives: To develop an equation to predict dual plasma sample method (DPSM) Tc-99m-diethylene triamine pentaacetic acid (Tc-99m-DTPA) plasma clearance from single plasma sample method (SPSM), and to clarify the condition in which DPSM can be substituted by SPSM in measurement of glomerular filtration rate (GFR). Methods: Patients with chronic kidney disease (CKD) were selected. Watson modified Christensen and Groth equation was used to calculate Tc-99m-DTPA plasma clearance by SPSM (sGFR). The equation recommended by the Nephrourology Committee of the Society of Nuclear Medicine was used to calculate Tc-99m-DTPA plasma clearance by DPSM (tGFR) in each patient. The difference between sGFR and tGFR was expressed as percent of the average of these two methods, and tGFR was predicted from sGFR. Plasma creatinine was measured by the kinetic picrate method, and GFR estimated by abbreviated modification of diet in renal disease (MDRD) equation (aGFR) and Cockcroft-Gault equation (cGFR) were evaluated as criteria in selection of DPSM and SPSM. Results: Three hundred and sixty-nine patients with CKD were selected (208 male and 161 female). The average age and body weight were 51.4 +/- 15.5 years and 67.2 +/- 12.5 kg, respectively. The causes of CKD were glomerular disease, renal arterial stenosis, chronic tubulointerstitial disease, and other causes or causes unknown. The average tGFR was 62.9 +/- 36.5 ml/min/1.73 m(2), ranging from 1-180 ml/min/1.73 m(2). sGFR was significantly correlated with tGFR (r = 0.9194, p < 0.001), but widely scattered when tGFR < 30 ml/min/1.73 m(2); in contrast, then tGFR was 30 ml/min/1.73 m(2), the difference was constant (-1.1%, 95% confidence interval -18.3%, 16.1%), and tGFR could be predicted from sGFR using the equation: predicted tGFR (ml/min/1.73 m(2)) = 7.4244 + 0.7318 X sGFR + 0.0022 x sGFR(2) (n = 299, r(2) = 0.9428, p < 0.001), and the difference decreased to 0.1%, 95% confidence interval (-15.8%, 16.0%). aGFR was better than cGFR in diagnosis of tGFR < 30ml/min/1.73 m(2). the diagnostic sensitivity of a cut off value of a GFR = 45 ml/min/1.73 m(2) was 91.8%, and recommended as a criterion in the selection of DPSM and SPSM. Conclusion: When GFR 30 ml/min/1.73 m(2), tGFR can be predicted from sGFR, which will simplify the reference GFR measurement in clinical trials. sGFR becomes widely scattered when tGFR is less than 30 ml/min/1.73 m(2). To obtain reliable reference GFR values, it is 2 recommended that DPSM be used in clinical trials when aGFR is less than 45 ml/min/1.73 m.

语种英语
WOS记录号WOS:000231516100007
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50517
专题北京大学第一临床医学院_肾脏内科
作者单位1.Peking Univ, Hosp 1, Inst Nephrol, Beijing 100034, Peoples R China
2.Peking Univ, Hosp 1, Inst Nucl Med, Beijing 100034, Peoples R China
推荐引用方式
GB/T 7714
Zuo, L,Ma, YC,Wang, M,et al. Prediction of two-sample Tc-99m-diethylene triamine pentaacetic acid plasma clearance from single-sample method[J]. ANNALS OF NUCLEAR MEDICINE,2005,19(5):399-405.
APA Zuo, L,Ma, YC,Wang, M,Zhang, CL,Wang, RF,&Wang, HY.(2005).Prediction of two-sample Tc-99m-diethylene triamine pentaacetic acid plasma clearance from single-sample method.ANNALS OF NUCLEAR MEDICINE,19(5),399-405.
MLA Zuo, L,et al."Prediction of two-sample Tc-99m-diethylene triamine pentaacetic acid plasma clearance from single-sample method".ANNALS OF NUCLEAR MEDICINE 19.5(2005):399-405.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Zuo, L]的文章
[Ma, YC]的文章
[Wang, M]的文章
百度学术
百度学术中相似的文章
[Zuo, L]的文章
[Ma, YC]的文章
[Wang, M]的文章
必应学术
必应学术中相似的文章
[Zuo, L]的文章
[Ma, YC]的文章
[Wang, M]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。