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学科主题: 基础医学
题名:
Pathology of the thyroid in severe acute respiratory syndrome
作者: Wei, Lan1; Sun, Shen1; Xu, Cai-hong1; Zhang, Jing1; Xu, Yun1; Zhu, Hong1; Peh, Suat-cheng1; Korteweg, Christine1; McNutt, Michael A.1; Gu, Jiang1
关键词: SARS ; thyroid ; calcitonin ; TUNEL
刊名: HUMAN PATHOLOGY
发表日期: 2007
DOI: 10.1016/j.humpath.2006.06.011
卷: 38, 期:1, 页:95-102
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pathology
研究领域[WOS]: Pathology
关键词[WOS]: SYNDROME-ASSOCIATED CORONAVIRUS ; SYNDROME SARS ; IMMUNE-SYSTEM ; CELL-DEATH ; THYROCALCITONIN ; APOPTOSIS ; BONE ; PROTEIN ; PATHOGENESIS ; NECROSIS
英文摘要:

The severe acute respiratory syndrome (SARS) epidemic started in November 2002 and spread worldwide. The pathological changes in several human organs of patients with SARS have been extensively described. However, to date, little has been reported about the effects of this infection on the thyroid gland. Femoral head necrosis and low serum triiodothyronine and thyroxine levels, commonly found in patients with SARS, raise the possibility of thyroid dysfunction. We have undertaken this study to evaluate for any potential injury to the thyroid gland caused by SARS on tissue samples obtained from 5 SARS autopsies. The terminal deoxynucleotidyl transferase-mediated dUPT nick end-labeling assay was performed to identify apoptotic cells. The follicular epithelium was found to be damaged with large numbers of cells exfoliated into the follicle. The terminal deoxyntrcleotidyl transferase-mediated dUPT nick end-labeling assay demonstrated many cells undergoing apoptosis. Follicular architecture was altered and showed distortion, dilatation, and collapse. No distinct calcitonin-positive cells were detectable in the SARS thyroids. In conclusion, both parafollicular and follicular cells were injured. This may provide an explanation both for low serum triiodothyronine and thyroxine levels and the osteonecrosis of the femoral head associated with patients with SARS. Apoptosis may play a role in the pathogenesis of SARS associated coronavirus infection in the thyroid gland. (c) 2007 Elsevier Inc. All rights reserved.

语种: 英语
WOS记录号: WOS:000243267000012
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50523
Appears in Collections:基础医学院_病理学系_期刊论文

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作者单位: 1.Peking Univ, Sch Basic Med Sci, Dept Pathol, Beijing 100083, Peoples R China
2.Peking Univ, Sch Basic Med Sci, Dept Anat Histol & Embryol, Beijing 100083, Peoples R China
3.Xuzhou Med Coll, Dept Histol & Embryol, Xuzhou 221002, Jiangsu, Peoples R China
4.Chinese Acad Sci, Natl Ctr Nanosci & Technol, Beijing 100080, Peoples R China

Recommended Citation:
Wei, Lan,Sun, Shen,Xu, Cai-hong,et al. Pathology of the thyroid in severe acute respiratory syndrome[J]. HUMAN PATHOLOGY,2007,38(1):95-102.
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