IR@PKUHSC  > 北京大学基础医学院  > 病理学系
学科主题基础医学
Pathology of the thyroid in severe acute respiratory syndrome
Wei, Lan1; Sun, Shen1; Xu, Cai-hong1; Zhang, Jing1; Xu, Yun1; Zhu, Hong1; Peh, Suat-cheng1; Korteweg, Christine1; McNutt, Michael A.1; Gu, Jiang1
关键词SARS thyroid calcitonin TUNEL
刊名HUMAN PATHOLOGY
2007
DOI10.1016/j.humpath.2006.06.011
38期:1页:95-102
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pathology
研究领域[WOS]Pathology
关键词[WOS]SYNDROME-ASSOCIATED CORONAVIRUS ; SYNDROME SARS ; IMMUNE-SYSTEM ; CELL-DEATH ; THYROCALCITONIN ; APOPTOSIS ; BONE ; PROTEIN ; PATHOGENESIS ; NECROSIS
英文摘要

The severe acute respiratory syndrome (SARS) epidemic started in November 2002 and spread worldwide. The pathological changes in several human organs of patients with SARS have been extensively described. However, to date, little has been reported about the effects of this infection on the thyroid gland. Femoral head necrosis and low serum triiodothyronine and thyroxine levels, commonly found in patients with SARS, raise the possibility of thyroid dysfunction. We have undertaken this study to evaluate for any potential injury to the thyroid gland caused by SARS on tissue samples obtained from 5 SARS autopsies. The terminal deoxynucleotidyl transferase-mediated dUPT nick end-labeling assay was performed to identify apoptotic cells. The follicular epithelium was found to be damaged with large numbers of cells exfoliated into the follicle. The terminal deoxyntrcleotidyl transferase-mediated dUPT nick end-labeling assay demonstrated many cells undergoing apoptosis. Follicular architecture was altered and showed distortion, dilatation, and collapse. No distinct calcitonin-positive cells were detectable in the SARS thyroids. In conclusion, both parafollicular and follicular cells were injured. This may provide an explanation both for low serum triiodothyronine and thyroxine levels and the osteonecrosis of the femoral head associated with patients with SARS. Apoptosis may play a role in the pathogenesis of SARS associated coronavirus infection in the thyroid gland. (c) 2007 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000243267000012
引用统计
被引频次:12[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50523
专题北京大学基础医学院_病理学系
作者单位1.Peking Univ, Sch Basic Med Sci, Dept Pathol, Beijing 100083, Peoples R China
2.Peking Univ, Sch Basic Med Sci, Dept Anat Histol & Embryol, Beijing 100083, Peoples R China
3.Xuzhou Med Coll, Dept Histol & Embryol, Xuzhou 221002, Jiangsu, Peoples R China
4.Chinese Acad Sci, Natl Ctr Nanosci & Technol, Beijing 100080, Peoples R China
推荐引用方式
GB/T 7714
Wei, Lan,Sun, Shen,Xu, Cai-hong,et al. Pathology of the thyroid in severe acute respiratory syndrome[J]. HUMAN PATHOLOGY,2007,38(1):95-102.
APA Wei, Lan.,Sun, Shen.,Xu, Cai-hong.,Zhang, Jing.,Xu, Yun.,...&Gu, Jiang.(2007).Pathology of the thyroid in severe acute respiratory syndrome.HUMAN PATHOLOGY,38(1),95-102.
MLA Wei, Lan,et al."Pathology of the thyroid in severe acute respiratory syndrome".HUMAN PATHOLOGY 38.1(2007):95-102.
条目包含的文件 下载所有文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
Pathology of the thy(1322KB)期刊论文出版稿开放获取CC BY-NC-SA浏览 下载
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Wei, Lan]的文章
[Sun, Shen]的文章
[Xu, Cai-hong]的文章
百度学术
百度学术中相似的文章
[Wei, Lan]的文章
[Sun, Shen]的文章
[Xu, Cai-hong]的文章
必应学术
必应学术中相似的文章
[Wei, Lan]的文章
[Sun, Shen]的文章
[Xu, Cai-hong]的文章
相关权益政策
暂无数据
收藏/分享
文件名: Pathology of the thyroid in severe acute respiratory syndrome.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。