北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 中国药物依赖性研究所  > 期刊论文
学科主题: 药物依赖
题名:
Calmodulin inhibitor trifluoperazine attenuates the development and expression of morphine-induced conditioned place preference in rats
作者: Ye, XF; Lu, Y; Zhang, P; Liang, JH
关键词: morphine ; conditioned place preference ; calmodulin ; trifluoperazine
刊名: EUROPEAN JOURNAL OF PHARMACOLOGY
发表日期: 2004-02-23
DOI: 10.1016/j.ejphar.2004.01.002
卷: 486, 期:3, 页:265-271
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: PROTEIN-KINASE-II ; OPIOID RECEPTORS ; DRUGS ; ANTAGONISTS ; DEPENDENCE ; TOLERANCE ; COCAINE ; BRAIN ; NEUROTRANSMITTER ; INVOLVEMENT
英文摘要:

The effect of trifluoperazine, a calmodulin inhibitor, on morphine-induced conditioned place preference was examined in rats. Morphine (5, 10 mg/kg, i.p.) produced significant place preference for the drug-associated place. Trifluoperazine significantly suppressed the development as well as the expression of morphine-induced place preference in a dose-dependent manner, but it neither produced place preference or aversion, nor affected locomotor activity. Injection of 0.5 and 1.0 mg/kg apomorphine, a dopamine receptor agonist, did not alter the inhibition by trifluoperazine of morphine-induced place preference. Verapamil, at the dose that failed to change the place preference induced by morphine, enhanced the inhibition by trifluoperazine of morphine-induced place preference. These findings provide the first demonstration that trifluoperazine attenuates morphine-induced conditioned place preference in rats. The action of trifluoperazine might be produced through its inhibition of calmodulin, but is probably not related to dopamine receptor blockade. (C) 2004 Elsevier B.V. All rights reserved.

语种: 英语
WOS记录号: WOS:000220018400004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50530
Appears in Collections:中国药物依赖性研究所_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: Peking Univ, Natl Inst Drug Dependence, Dept Neuropharmacol, Beijing 100083, Peoples R China

Recommended Citation:
Ye, XF,Lu, Y,Zhang, P,et al. Calmodulin inhibitor trifluoperazine attenuates the development and expression of morphine-induced conditioned place preference in rats[J]. EUROPEAN JOURNAL OF PHARMACOLOGY,2004,486(3):265-271.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Ye, XF]'s Articles
[Lu, Y]'s Articles
[Zhang, P]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Ye, XF]‘s Articles
[Lu, Y]‘s Articles
[Zhang, P]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace