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Effects of Ifenprodil on Morphine-Induced Conditioned Place Preference and Spatial Learning and Memory in Rats
Ma, Yao-Ying; Yu, Peng; Guo, Chang-Yong; Cui, Cai-Lian
关键词Ifenprodil Morphine Conditioned place preference Spatial learning and memory NMDA receptor Rats
刊名NEUROCHEMICAL RESEARCH
2011-03-01
DOI10.1007/s11064-010-0342-9
36期:3页:383-391
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Neurosciences
研究领域[WOS]Biochemistry & Molecular Biology ; Neurosciences & Neurology
关键词[WOS]DRUG-INDUCED REINSTATEMENT ; ELECTRICAL STIMULATIONS SUPPRESS ; NMDA RECEPTOR ANTAGONISTS ; COCAINE-SEEKING BEHAVIOR ; NUCLEUS-ACCUMBENS ; MOLECULAR-MECHANISMS ; SYNAPTIC PLASTICITY ; DENDRITIC SPINES ; INDUCED CPP ; ADDICTION
英文摘要

Drug addiction, as well as learning and memory, share common mechanisms in terms of neural circuits and intracellular signaling pathways. In the present study, the role of N-methyl-D-aspartate (NMDA) receptors, particularly those containing NR2B subunits, in morphine-induced conditioned place preference (CPP) and Morris water maze (MWM) learning and memory task was investigated. CPP was used as a paradigm for assessing the rewarding effect of morphine, and MWM was used to measure spatial learning and memory in male Sprague-Dawley rats. We found that ifenprodil, an antagonist highly selective for NR2B-containing NMDA receptors, dose-dependently blocked the development, maintenance and reinstatement of morphine-induced CPP, without evident impairment of the acquisition and retrieval of spatial memory in the MWM task. However, the consolidation of spatial memory was disrupted by a high dose (10 mg/kg) of ifenprodil. These results clearly demonstrate that NR2B-containing NMDA receptors are actively involved in addiction memory induced by morphine conditioning, but not in the acquisition and retrieval of spatial learning and memory. In conclusion, NR2B-containing NMDA receptors can be considered potential targets for the treatment of opiate addiction.

语种英语
WOS记录号WOS:000286990100004
项目编号30970933 ; 2009CB522003
资助机构National Natural Science Foundation ; National Basic Research Program of China
引用统计
被引频次:26[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50536
专题北京大学基础医学院_神经生物学系
北京大学基础医学院
作者单位Peking Univ, Neurosci Res Inst, Dept Neurobiol,Minist Educ, Sch Basic Med Sci,Minist Publ Hlth,Key Lab Neuros, Beijing 100083, Peoples R China
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Ma, Yao-Ying,Yu, Peng,Guo, Chang-Yong,et al. Effects of Ifenprodil on Morphine-Induced Conditioned Place Preference and Spatial Learning and Memory in Rats[J]. NEUROCHEMICAL RESEARCH,2011,36(3):383-391.
APA Ma, Yao-Ying,Yu, Peng,Guo, Chang-Yong,&Cui, Cai-Lian.(2011).Effects of Ifenprodil on Morphine-Induced Conditioned Place Preference and Spatial Learning and Memory in Rats.NEUROCHEMICAL RESEARCH,36(3),383-391.
MLA Ma, Yao-Ying,et al."Effects of Ifenprodil on Morphine-Induced Conditioned Place Preference and Spatial Learning and Memory in Rats".NEUROCHEMICAL RESEARCH 36.3(2011):383-391.
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