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学科主题临床医学
Association between human atrial natriuretic peptide Val7Met polymorphism and baseline blood pressure, plasma trough irbesartan concentrations, and the antihypertensive efficacy of irbesartan in rural chinese patients with essential hypertension
Zhang, SC1; Mao, GY1; Zhang, Y1; Tang, GF1; Wen, YF1; Hong, XM1; Jiang, SQ1; Yu, YX1; Xu, XP1
关键词Irbesartan Antihypertensive Efficacy Hypertension Atrial Natriuretic Peptide Polymorphism Chinese
刊名CLINICAL THERAPEUTICS
2005-11-01
DOI10.1016/j.clinthera.2005.11.008
27期:11页:1774-1784
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pharmacology & Pharmacy
研究领域[WOS]Pharmacology & Pharmacy
关键词[WOS]RECEPTOR GENE ; DRUG-THERAPY ; RISK-FACTORS ; MANAGEMENT ; RENIN ; ANP ; ALDOSTERONE ; POPULATION ; EXCRETION ; VARIANTS
英文摘要

Background: Individual variations in the pharmacokinetics and pharmacodynamics of antihypertensive drugs are influenced by genetic and environmental factors. The ANP gene, which encodes the precursor of atrial natriuretic peptide (ANP), is among the candidate genes for genetic susceptibility to hypertension.

Objective: This study examined the relationship between ANP Val7Met polymorphism (Single Nucleotide Polymorphism database ID: rs5063) and baseline blood pressure (BP), plasma trough irbesartan concentrations, and the antihypertensive efficacy of irbesartan in rural Chinese patients with essential hypertension.

Methods: Patients with essential hypertension who had taken no antihypertensive medications within 4 weeks of study initiation received oral irbesartan 150 mg/d for 4 weeks. Genotyping was performed for all patients. BP was measured before dosing on the 1st and 28th days of treatment. Plasma irbesartan concentrations were measured using high-performance liquid chromatography with fluorescent detection. Antihypertensive efficacy was defined as attainment of a diastolic BP (DBP) <90 mm Hg (DBP analysis), a systolic BP (SBP) <140 mm Hg (SBP analysis), and a DBP <90 mm Hg and SBP <140 mm Hg (DBP and SBP analysis).

Results: The study included 756 patients, 621 with the Val/Val genotype and 135 with the Val/Met+Met/Met genotypes. There were no significant differences in age, body mass index, sex, education level, occupation, alcohol consumption, or smoking status between the 2 groups. Patients with the Val/Met+Met/Met genotypes had a significantly lower mean baseline DBP compared with those with the Val/Val genotype (adjusted regression coefficient [SE]: -2.5 [1.0] mm Hg; P = 0.012) and significantly lower mean steady-state plasma trough irbesartan concentrations (adjusted regression coefficient: -12.6 [4.1]; P = 0.002). No significant association was found between antihypertensive efficacy and Val7Met polymorphism in the overall population, but in an analysis by baseline DBP status, patients with the Val/Met+Met/Met genotype and a baseline DBP a:100 mm Hg had significantly smaller reductions in DBP (adjusted regression coefficient: -5.7 [1.4] mm Hg; P < 0.001) and SBP compared with those with the Val/Val genotype and a baseline DBP a:100 mm Hg (adjusted regression coefficient: -9.8 [2.9] mm Hg; P < 0.001).

Conclusion: The findings of this study suggest that in these rural Chinese patients with essential hypertension, ANP Val/Met polymorphism may be a genetic marker for baseline DBP, plasma irbesartan concentrations, and the antihypertensive efficacy of short-term irbesartan therapy.

语种英语
WOS记录号WOS:000234126000008
引用统计
被引频次:21[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50538
专题北京大学第一临床医学院_心血管内科
作者单位1.Univ Sci & Technol China, Sch Life Sci, Hefei 230026, Anhui, Peoples R China
2.Anhui Med Univ, Inst Biomed, Hefei 230026, Anhui, Peoples R China
3.Peking Univ, Hosp 1, Dept Cardiovasc Dis, Beijing, Peoples R China
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GB/T 7714
Zhang, SC,Mao, GY,Zhang, Y,et al. Association between human atrial natriuretic peptide Val7Met polymorphism and baseline blood pressure, plasma trough irbesartan concentrations, and the antihypertensive efficacy of irbesartan in rural chinese patients with essential hypertension[J]. CLINICAL THERAPEUTICS,2005,27(11):1774-1784.
APA Zhang, SC.,Mao, GY.,Zhang, Y.,Tang, GF.,Wen, YF.,...&Xu, XP.(2005).Association between human atrial natriuretic peptide Val7Met polymorphism and baseline blood pressure, plasma trough irbesartan concentrations, and the antihypertensive efficacy of irbesartan in rural chinese patients with essential hypertension.CLINICAL THERAPEUTICS,27(11),1774-1784.
MLA Zhang, SC,et al."Association between human atrial natriuretic peptide Val7Met polymorphism and baseline blood pressure, plasma trough irbesartan concentrations, and the antihypertensive efficacy of irbesartan in rural chinese patients with essential hypertension".CLINICAL THERAPEUTICS 27.11(2005):1774-1784.
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