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Clinicopathologic spectrum of the so-called calcifying odontogenic cysts - A study of 21 intraosseous cases with reconsideration of the terminology and classification
Li, TJ; Yu, SF
关键词Calcifying Odontogenic Cyst Odontogenic Tumor Odontogenic Carcinoma Jaws
刊名AMERICAN JOURNAL OF SURGICAL PATHOLOGY
2003-03-01
27期:3页:372-384
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pathology ; Surgery
研究领域[WOS]Pathology ; Surgery
关键词[WOS]GHOST CELL TUMOR ; CARCINOMA ; AMELOBLASTOMA ; ODONTOMA
英文摘要

The so-called calcifying odontogenic cyst (COC) represents a heterogeneous group of lesions that exhibit a variety of clinicopathologic and behavioral features. Because of this diversity, there has been confusion and disagreement on the terminology and classification of these lesions. We reviewed the clinicopathologic features of 21 intraosseous cases that were previously diagnosed as COC or under related diagnostic terms. Based on the biologic behavior, the lesions of the present series were divided into three subgroups: cyst, benign tumor, and malignant tumor. Sixteen cases (nine men and seven women) proved to be unicystic lesions with (five cases) or without associated odontoma. The lining epithelium of the cystic lesions fulfilled the histologic criteria for COC proposed by the World Health Organization, and their overall clinicopathologic features were consistent with that of developmental odontogenic cysts. The age of patients from the cyst group peaked at the second decade. The maxilla was affected more often (69%) than the mandible, with a predilection for the canine-premolar region (62.5%). Thirteen patients with follow-up information revealed no recurrence following enucleation. The four cases in the benign tumor group had variable clinicopathologic features. Two cases were solid tumors consisting of ameloblastoma-like sheets of odontogenic epithelium that contained ghost cells/calcification foci and juxtaepithelial dentinoid. Both patients experienced multiple recurrences following conservative surgeries. The other two lesions contained typical areas of COC and other types of odontogenic tumors (one ameloblastoma and one odontogenic myxofibroma). All four lesions occurred in the mandible and were relatively large. In the present series one case identified as malignant tumor arose from a previously benign COC. The tumor shared some features of COC (ghost cell foci and dystrophic calcification) but also had prominent mitotic activity, nuclear and cytoplasmic pleomorphism, areas of tumor necrosis, and infiltrative/destructive growth. Recognizing the extreme diversity in clinicopathologic features and biologic behavior among the so-called COCs, we suggest that the term COC should be used to specifically designate the unicystic lesions with or without an associated odontoma, i.e., lesions of the cyst group, and other related lesions identified as benign tumor and malignant tumor should be termed and classified separately. A tentative scheme with respect to the terminology and classification for this group of disparately behaving lesions was herein proposed to reflect the likely difference of their nature.

语种英语
WOS记录号WOS:000181245900011
引用统计
被引频次:51[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50539
专题北京大学口腔医学院_口腔病理科
作者单位Peking Univ, Sch Stomatol, Dept Oral Pathol, Beijing 100081, Peoples R China
推荐引用方式
GB/T 7714
Li, TJ,Yu, SF. Clinicopathologic spectrum of the so-called calcifying odontogenic cysts - A study of 21 intraosseous cases with reconsideration of the terminology and classification[J]. AMERICAN JOURNAL OF SURGICAL PATHOLOGY,2003,27(3):372-384.
APA Li, TJ,&Yu, SF.(2003).Clinicopathologic spectrum of the so-called calcifying odontogenic cysts - A study of 21 intraosseous cases with reconsideration of the terminology and classification.AMERICAN JOURNAL OF SURGICAL PATHOLOGY,27(3),372-384.
MLA Li, TJ,et al."Clinicopathologic spectrum of the so-called calcifying odontogenic cysts - A study of 21 intraosseous cases with reconsideration of the terminology and classification".AMERICAN JOURNAL OF SURGICAL PATHOLOGY 27.3(2003):372-384.
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