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Telbivudine treatment is associated with high hepatitis B e antigen seroconversion and immune modulatory effects in chronic hepatitis B patients
Wang, G. -Q.1,2; Ding, Y. -P.1,2; Dong, Y. -H.3
关键词Chronic Hepatitis b Hbeag Seroconversion Immune Modulatory Telbivudine
刊名JOURNAL OF VIRAL HEPATITIS
2013-04-01
DOI10.1111/jvh.12059
suppl.1期:SI页:9-17
收录类别SCI
文章类型Review
WOS标题词Science & Technology
类目[WOS]Gastroenterology & Hepatology ; Infectious Diseases ; Virology
研究领域[WOS]Gastroenterology & Hepatology ; Infectious Diseases ; Virology
关键词[WOS]DEATH-LIGAND 1 ; REGULATORY T-CELLS ; DOUBLE-BLIND TRIAL ; TERM-FOLLOW-UP ; ADEFOVIR DIPIVOXIL ; LAMIVUDINE TREATMENT ; HEPATOCELLULAR-CARCINOMA ; PEGINTERFERON ALPHA-2A ; HBEAG SEROCONVERSION ; SUSTAINED RESPONSE
英文摘要

Chronic hepatitis B (CHB) is characterized by an impaired immune response to hepatitis B virus. Among the nucleos(t)ides used in CHB treatment, telbivudine is associated with the highest rates of hepatitis B e antigen (HBeAg) seroconversion rates, which are similar to those observed with pegylated interferon (PegIFN). Besides direct antiviral effect, modulation of the immune system may be an additional benefit for telbivudine-treated patients. Indeed, there is much clinical data indicating an IFN-like behaviour for telbivudine in contrast to other oral nucleos(t)ides, such as high HBeAg seroconversion, similar hepatitis B surface antigen (HBsAg) decline and biphasic viral kinetics. Clinical studies, animal models and in vitro studies suggest that both the innate and adaptive immune system responses contribute to high HBeAg seroconversion during telbivudine treatment through modulation of the function and/or expression of CD4+/CD8+ T cells, Th1/Th2, Treg, PD-1/PD-L1, Th17, IL-21 and TFH. The results described in this review suggest that the antiviral effect of telbivudine may be attributable not only to direct suppression of hepatitis B virus, but also to immunoregulatory effects. Hypothetically, telbivudine shares some common signal pathways with IFN.

语种英语
WOS记录号WOS:000315822400004
项目编号008ZX10002-008 ; 2012ZX10002-006 ; 2012ZX09312-011
资助机构National Major Science and Technology Special Project of China
引用统计
被引频次:11[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50541
专题北京大学第一临床医学院_感染疾病科
作者单位1.Peking Univ, Hosp 1, Dept Infect Dis, Beijing 100871, Peoples R China
2.Peking Univ, Hosp 1, Ctr Liver Dis, Beijing 100871, Peoples R China
3.Novartis Pharmaceut, Basel, Switzerland
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GB/T 7714
Wang, G. -Q.,Ding, Y. -P.,Dong, Y. -H.. Telbivudine treatment is associated with high hepatitis B e antigen seroconversion and immune modulatory effects in chronic hepatitis B patients[J]. JOURNAL OF VIRAL HEPATITIS,2013,suppl.1(SI):9-17.
APA Wang, G. -Q.,Ding, Y. -P.,&Dong, Y. -H..(2013).Telbivudine treatment is associated with high hepatitis B e antigen seroconversion and immune modulatory effects in chronic hepatitis B patients.JOURNAL OF VIRAL HEPATITIS,suppl.1(SI),9-17.
MLA Wang, G. -Q.,et al."Telbivudine treatment is associated with high hepatitis B e antigen seroconversion and immune modulatory effects in chronic hepatitis B patients".JOURNAL OF VIRAL HEPATITIS suppl.1.SI(2013):9-17.
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