IR@PKUHSC  > 北京大学基础医学院  > 药理学系
学科主题基础医学
In vitro inhibitory effects of bergenin and norbergenin on bovine adrenal tyrosine hydroxylase
Zhang, YH1; Fang, LH1; Lee, MK1; Ku, BS1
关键词Bergenin Norbergenin Bovine Adrenal Tyrosine Hydroxylase L-tyrosine Noncompetitive Inhibition
刊名PHYTOTHERAPY RESEARCH
2003-09-01
DOI10.1002/ptr.1292
17期:8页:967-969
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]Pharmacology & Pharmacy
关键词[WOS]SYNTHESIZING SYSTEM ; STRESS ; ULCERS ; RATS
英文摘要

The aqueous extract of Mallotus japonicus (Euphorbiaceae) showed an inhibitory effect on bovine adrenal tyrosine hydroxylase (TH), the rate-limiting enzyme in the biosynthesis of catecholamine. The present study was undertaken to investigate the effects of bergenin and norbergenin, constituents of the aqueous extract of Mallotus japonicus on bovine adrenal TH. Bergenin and norbergenin inhibited the TH activity by 29.0% and 53.4% at a concentration of 20 mug/mL, respectively, and exhibited noncompetitive inhibition of TH activity with the substrate L-tyrosine. The inhibition of TH activity and the inhibitory effect of norbergenin was more potent than that of bergenin. From these results, it is presumed that bergenin and norbergenin may be the active components of Mallotus japonicus in inhibiting TH, and these inhibitory effects may be partially responsible for the clinical use of Mallotus japonicus in treating peptic ulcer by reducing the availability of dopa/dopamine in vivo. Copyright (C) 2003 John Wiley Sons, Ltd.

语种英语
WOS记录号WOS:000185509400024
引用统计
被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50542
专题北京大学基础医学院_药理学系
北京大学基础医学院
作者单位1.Peking Univ, Dept Pharmacol, Sch Basic Med Sci, Beijing 100083, Peoples R China
2.Beijing Univ, State Special Lab Bioorgan Mol Engn, Coll Chem & Mol Engn, Beijing 100871, Peoples R China
3.Chungbuk Natl Univ, Coll Pharm, Dept Pharmacol, Cheongju 361763, South Korea
推荐引用方式
GB/T 7714
Zhang, YH,Fang, LH,Lee, MK,et al. In vitro inhibitory effects of bergenin and norbergenin on bovine adrenal tyrosine hydroxylase[J]. PHYTOTHERAPY RESEARCH,2003,17(8):967-969.
APA Zhang, YH,Fang, LH,Lee, MK,&Ku, BS.(2003).In vitro inhibitory effects of bergenin and norbergenin on bovine adrenal tyrosine hydroxylase.PHYTOTHERAPY RESEARCH,17(8),967-969.
MLA Zhang, YH,et al."In vitro inhibitory effects of bergenin and norbergenin on bovine adrenal tyrosine hydroxylase".PHYTOTHERAPY RESEARCH 17.8(2003):967-969.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
In vitro inhibitory (81KB)期刊论文出版稿开放获取CC BY-NC-SA浏览 请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Zhang, YH]的文章
[Fang, LH]的文章
[Lee, MK]的文章
百度学术
百度学术中相似的文章
[Zhang, YH]的文章
[Fang, LH]的文章
[Lee, MK]的文章
必应学术
必应学术中相似的文章
[Zhang, YH]的文章
[Fang, LH]的文章
[Lee, MK]的文章
相关权益政策
暂无数据
收藏/分享
文件名: In vitro inhibitory effects of bergenin and norbergenin on bovine adrenal tyrosine hydroxylase.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。