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学科主题: 精神卫生
题名:
Nicotine dependence, symptoms and oxidative stress in male patients with schizophrenia
作者: Zhang, Xiang Yang1; Tan, Yun Long1; Zhou, Dong Feng1; Haile, Colin N.1; Wu, Gui Ying1; Cao, Lian Yuan1; Kosten, Therese A.1; Kosten, Thomas R.1
关键词: schizophrenia ; nicotine ; cigarette smoking ; oxidative stress ; antioxidant enzymes ; symptom
刊名: NEUROPSYCHOPHARMACOLOGY
发表日期: 2007-09-01
DOI: 10.1038/sj.npp.1301317
卷: 32, 期:9, 页:2020-2024
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences ; Pharmacology & Pharmacy ; Psychiatry
研究领域[WOS]: Neurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry
关键词[WOS]: LIPID-PEROXIDATION ; PARKINSONS-DISEASE ; CIGARETTE-SMOKING ; TOBACCO SMOKING ; DIFFERENT FORMS ; IN-VITRO ; ENZYMES ; ASSOCIATION ; RELEVANCE ; DOPAMINE
英文摘要:

The high rate of smoking in schizophrenia may reflect patients′ attempts to reduce the side effects of antipsychotic medications, and one mechanism for this reduction may be a reduction in oxidative stress and free radical-mediated brain damage that may contribute to schizophrenic symptoms and to complications of its treatment. Symptoms were assessed with the Positive and Negative Syndrome Scale (PANSS), side effects were assessed with the Simpson and Angus Rating Scale ( SAS), and malondialdehyde (MDA), superoxide dismutase ( SOD), glutathione peroxidase (GSH- Px) and catalase ( CAT) activities were measured in plasma. All of these measures were compared in 130 male inpatients with DSM-IV schizophrenia: 104 smokers and 26 non-smokers. The results showed that the positive PANSS symptoms were lower in smokers than non-smokers (14.5 vs 17.5), while the negative symptoms were lower in those who smoked more cigarettes (r = -0.23). The SAS showed no differences. The CAT activity was correlated with both GSH- Px and SOD activities. Of the three enzymes only the CAT activity was significantly higher in smokers than non-smokers ( 2.9 vs 1.6 U/ml), but greater SOD activity correlated more cigarettes smoked ( r = 0.24). Consistent with some protection against oxidative stress, MDA also was significantly lower in smokers than non-smokers (9.2 vs 14.4 nmol/ml). The fewer positive symptoms in smokers and fewer negative symptoms in those who smoked more cigarettes may be a selection bias, but appears to be associated with decreased oxidative stress and lipid peroxidation in schizophrenics who smoke tobacco.

语种: 英语
WOS记录号: WOS:000248788900017
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50546
Appears in Collections:北京大学精神卫生研究所_期刊论文

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作者单位: 1.Baylor Coll Med, VA Med Ctr, Menninger Dept Psychiat & Behav Sci, Houston, TX 77030 USA
2.Peking Univ, Inst Mental Hlth, Beijing 100871, Peoples R China
3.Beijing HuiLongGuan Hosp, Ctr Biol Psychiat, Beijing, Peoples R China

Recommended Citation:
Zhang, Xiang Yang,Tan, Yun Long,Zhou, Dong Feng,et al. Nicotine dependence, symptoms and oxidative stress in male patients with schizophrenia[J]. NEUROPSYCHOPHARMACOLOGY,2007,32(9):2020-2024.
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