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学科主题: 公共卫生
题名:
Phage Display Applications for Molecular Imaging
作者: Cai, Jiong1,2; Liu, Zhaofei3; Wang, Fan3; Li, Fang1,2
关键词: Phage display ; molecular imaging ; tumor ; peptide ; antibody
刊名: CURRENT PHARMACEUTICAL BIOTECHNOLOGY
发表日期: 2010-09-01
卷: 11, 期:6, 页:603-609
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Pharmacology & Pharmacy
研究领域[WOS]: Biochemistry & Molecular Biology ; Pharmacology & Pharmacy
关键词[WOS]: MEDULLARY-THYROID CARCINOMA ; CARBONIC-ANHYDRASE-IX ; TUMOR-HOMING PEPTIDE ; IN-VIVO ; BINDING PEPTIDE ; APOPTOSIS ; CANCER ; CELLS ; TECHNOLOGY ; LIBRARIES
英文摘要:

The advancement of molecular imaging hardware and disease targets has driven the demand of novel probes for diagnosis of human diseases. The high-throughput property of phage-display techniques makes the fast developments of these probes possible. The antibody and peptide phage display libraries have been widely used in ligand-selections for a variety of targets in tumors including osteosarcomas, pancreatic ductal adenocarcinomas, thyroid, head and neck squamous cell carcinomas, prostate, bladder, colon and gastric cancers. The phage display techniques also have been utilized in development of imaging agents for tumor therapy response, apoptosis, hypoxia, infection and inflammation, Alzheimer′s diseases, diabetes and cardiovascular diseases.

语种: 英语
所属项目编号: 30670741 ; 30870728 ; 20820102035 ; 30930030 ; 30900373 ; 2007AA02Z467 ; 2009ZX09103-733 ; 2009ZX09103-746 ; 2009ZX09301-010
项目资助者: NSFC ; "863" project ; Ministry of Science and Technology of China
WOS记录号: WOS:000281435100007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50547
Appears in Collections:北京大学医药卫生分析中心_期刊论文

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作者单位: 1.Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Nucl Med, Beijing 100730, Peoples R China
2.Chinese Acad Med Sci, Beijing 100730, Peoples R China
3.Peking Univ, Med Isotopes Res Ctr, Beijing 100191, Peoples R China

Recommended Citation:
Cai, Jiong,Liu, Zhaofei,Wang, Fan,et al. Phage Display Applications for Molecular Imaging[J]. CURRENT PHARMACEUTICAL BIOTECHNOLOGY,2010,11(6):603-609.
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