IR@PKUHSC  > 北京大学临床肿瘤学院
学科主题临床医学
Mycoplasma infections and different human carcinomas
Huang, S; Li, JY; Wu, J; Meng, L; Shou, CC
刊名WORLD JOURNAL OF GASTROENTEROLOGY
2001-04-01
7期:2页:266-269
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Gastroenterology & Hepatology
研究领域[WOS]Gastroenterology & Hepatology
关键词[WOS]MALIGNANT TRANSFORMATION ; CELLS ; CANCER ; SEQUENCE ; DNA ; PCR
英文摘要

CONCLUSION There was high correlation between mycoplasma infection and different cancers, which suggests the possibility of an association between the two, The mechanism involved in oncogenesis by mycoplasma remains unknown

AIM To explore relationships between human carcinomas and mycoplasma infection.

METHODS Monoclonal antibody PD4, which specifically recognizes a distinct protein from mycoplasma hyorhinis, was used to detect mycoplasma infection in different paraffin-embedded carcinoma tissues with immunohistochemistry. PCR was applied to amplify the mycoplasma DNA from the positive samples for confirming immunohistochemistry.

RESULTS Fifty of 90 cases (56%) of gastric carcinoma were positive for mycoplasma hyorhinis, In other gastric diseases, the mycoplasma infection ratio was 28% (18/ 49) in chronic superficial gastritis, 30% (14/ 46) in gastric ulcer and 37% (18/ 49) in intestinal metaplasia, The difference is significant with gastric cancer (chi (2) = 12.06, P <0.05), In colon carcinoma, the mycoplasma infection ratio was 55.1% (32/ 58), but it was 20.9% (10/ 49) in adenomarous polyp (chi (2) = 13.46, P <0.005). Gastric and colon cancers with high differentiation had a higher mycoplasma infection ratio than those with low differentiation (P <0.05). Mycoplasma infection in esophageal cancer, lung cancer, breast cancer and glioma was 50.9% (27/ 53), 52.6% (31/ 59), 39.7% (25/ 63) and 41% (38/ 91), respectively. The mycoplasma DNA was successfully amplified with the DNA extracted from the cancer tissues that were positive for mycoplasma infection (detected with antibody PD4).

CONCLUSION There was high correlation between mycoplasma infection and different cancers, which suggests the possibility of an association between the two, The mechanism involved in oncogenesis by mycoplasma remains unknown.

语种英语
WOS记录号WOS:000168299400020
引用统计
被引频次:91[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50553
专题北京大学临床肿瘤学院
北京大学第三临床医学院_财务处
北京大学临床肿瘤学院_生化与分子生物学研究室
作者单位Peking Univ, Dept Biochem & Mol Biol, Beijing Inst Canc Res, Sch Med, Beijing 100034, Peoples R China
推荐引用方式
GB/T 7714
Huang, S,Li, JY,Wu, J,et al. Mycoplasma infections and different human carcinomas[J]. WORLD JOURNAL OF GASTROENTEROLOGY,2001,7(2):266-269.
APA Huang, S,Li, JY,Wu, J,Meng, L,&Shou, CC.(2001).Mycoplasma infections and different human carcinomas.WORLD JOURNAL OF GASTROENTEROLOGY,7(2),266-269.
MLA Huang, S,et al."Mycoplasma infections and different human carcinomas".WORLD JOURNAL OF GASTROENTEROLOGY 7.2(2001):266-269.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Huang, S]的文章
[Li, JY]的文章
[Wu, J]的文章
百度学术
百度学术中相似的文章
[Huang, S]的文章
[Li, JY]的文章
[Wu, J]的文章
必应学术
必应学术中相似的文章
[Huang, S]的文章
[Li, JY]的文章
[Wu, J]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。