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学科主题: 临床医学
题名:
Mycoplasma infections and different human carcinomas
作者: Huang, S; Li, JY; Wu, J; Meng, L; Shou, CC
刊名: WORLD JOURNAL OF GASTROENTEROLOGY
发表日期: 2001-04-01
卷: 7, 期:2, 页:266-269
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Gastroenterology & Hepatology
研究领域[WOS]: Gastroenterology & Hepatology
关键词[WOS]: MALIGNANT TRANSFORMATION ; CELLS ; CANCER ; SEQUENCE ; DNA ; PCR
英文摘要:

CONCLUSION There was high correlation between mycoplasma infection and different cancers, which suggests the possibility of an association between the two, The mechanism involved in oncogenesis by mycoplasma remains unknown

AIM To explore relationships between human carcinomas and mycoplasma infection.

METHODS Monoclonal antibody PD4, which specifically recognizes a distinct protein from mycoplasma hyorhinis, was used to detect mycoplasma infection in different paraffin-embedded carcinoma tissues with immunohistochemistry. PCR was applied to amplify the mycoplasma DNA from the positive samples for confirming immunohistochemistry.

RESULTS Fifty of 90 cases (56%) of gastric carcinoma were positive for mycoplasma hyorhinis, In other gastric diseases, the mycoplasma infection ratio was 28% (18/ 49) in chronic superficial gastritis, 30% (14/ 46) in gastric ulcer and 37% (18/ 49) in intestinal metaplasia, The difference is significant with gastric cancer (chi (2) = 12.06, P <0.05), In colon carcinoma, the mycoplasma infection ratio was 55.1% (32/ 58), but it was 20.9% (10/ 49) in adenomarous polyp (chi (2) = 13.46, P <0.005). Gastric and colon cancers with high differentiation had a higher mycoplasma infection ratio than those with low differentiation (P <0.05). Mycoplasma infection in esophageal cancer, lung cancer, breast cancer and glioma was 50.9% (27/ 53), 52.6% (31/ 59), 39.7% (25/ 63) and 41% (38/ 91), respectively. The mycoplasma DNA was successfully amplified with the DNA extracted from the cancer tissues that were positive for mycoplasma infection (detected with antibody PD4).

CONCLUSION There was high correlation between mycoplasma infection and different cancers, which suggests the possibility of an association between the two, The mechanism involved in oncogenesis by mycoplasma remains unknown.

语种: 英语
WOS记录号: WOS:000168299400020
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50553
Appears in Collections:北京大学临床肿瘤学院_期刊论文

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作者单位: Peking Univ, Dept Biochem & Mol Biol, Beijing Inst Canc Res, Sch Med, Beijing 100034, Peoples R China

Recommended Citation:
Huang, S,Li, JY,Wu, J,et al. Mycoplasma infections and different human carcinomas[J]. WORLD JOURNAL OF GASTROENTEROLOGY,2001,7(2):266-269.
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