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学科主题: 临床医学
题名:
The orphan nuclear receptors, estrogen receptor-related receptors: Their role as new biomarkers in gynecological cancer
作者: Sun, PM1; Wei, LH1; Denkert, C1; Lichtenegger, W1; Sehouli, J1
关键词: orphan nuclear receptors ; ERR ; ER ; cross-talk ; biomarker ; review
刊名: ANTICANCER RESEARCH
发表日期: 2006-03-01
卷: 26, 期:2C, 页:1699-1706
收录类别: ISTP ; SCI
文章类型: Proceedings Paper
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: ALPHA ERR-ALPHA ; HUMAN LACTOFERRIN GENE ; RESPONSE ELEMENTS ; TRANSCRIPTIONAL ACTIVATION ; BREAST-CANCER ; EXPRESSION ; GAMMA ; PROMOTER ; BETA ; COACTIVATOR
英文摘要:

The family of estrogen receptor-related receptors (ERRs) is a subfamily of the orphan nuclear receptors, which is closely related to the estrogen receptor (ER) family. Research on ERRs has shown that the ERR family share target genes, co-regulators and promoters with the E R family. ERRs seem to interfere with the classic ER-mediated estrogen responsive signaling in various ways. Moreover, ERRs have been reported to be prognostic biomarkers in breast, ovarian and colorectal cancer. ERRs should be considered as additional factors in the evaluation of gynecological tumors. Since ERRs have an important influence on the overall estrogenic response, they are of clinical importance in gynecological cancer, but also regarding women′s general health.

语种: 英语
WOS记录号: WOS:000236684100005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50557
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: 1.Peking Univ, Peoples Hosp, Dept Gynecol Oncol, Beijing 100044, Peoples R China
2.Univ Med Berlin, Charite, Dept Obstet & Gynecol, D-13353 Berlin, Germany
3.Univ Med Berlin, Charite, Inst Pathol, D-10117 Berlin, Germany

Recommended Citation:
Sun, PM,Wei, LH,Denkert, C,et al. The orphan nuclear receptors, estrogen receptor-related receptors: Their role as new biomarkers in gynecological cancer[J]. ANTICANCER RESEARCH,2006,26(2C):1699-1706.
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