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Isolation, Structure Characterization, and Immunomodulating Activity of a Hyperbranched Polysaccharide from the Fruiting Bodies of Ganoderma sinense
Han, Xiao-Qiang1,2; Chan, Ben Chung Lap2; Dong, Cai-Xia3; Yang, Yin-Hua4,5; Ko, Chun-Hay2; Yue, Grace Gar-Lee2; Chen, Dan6; Wong, Chun-Kwok2,7; Lau, Clara Bik-San2; Tu, Peng-Fei1; Shaw, Pang-Chui4,5; Fung, Kwok-Pui2; Leung, Ping-Chung2; Hsiao, Wen-Luan3; Han, Quan-Bin2,3
关键词Ganoderma Sinense Polysaccharide Immunological Activity Cytokine Dendritic Cell
刊名JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
2012-05-02
DOI10.1021/jf205056u
60期:17页:4276-4281
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Agriculture, Multidisciplinary ; Chemistry, Applied ; Food Science & Technology
资助者Government of the Hong Kong Special Administrative Region ; Hong Kong Baptist University ; University Grants Council of Hong Kong SAR ; Government of the Hong Kong Special Administrative Region ; Hong Kong Baptist University ; University Grants Council of Hong Kong SAR
研究领域[WOS]Agriculture ; Chemistry ; Food Science & Technology
关键词[WOS]LUCIDUM POLYSACCHARIDES ; ANTIOXIDANT ACTIVITIES ; DENDRITIC CELLS ; PROTEIN ; IDENTIFICATION ; FUNGAL ; TRITERPENOIDS ; INDUCTION
英文摘要

A polysaccharide (GSP-6B) with a molecular mass of 1.86 x 10(6) Da was isolated from the fruiting bodies of Ganoderma sinense. Chemical composition analysis, methylation analysis, infrared spectroscopy, and nuclear magnetic resonance spectroscopy were conducted to elucidate its structure. GSP-6B contains a backbone of (1 -> 6)-linked-beta-D-glucopyranosyl residues, bearing branches at the O-3 position of every two sugar residues along the backbone. The side chains contain (1 -> 4)-linked-beta-D-glucopyranosyl residues, (1 -> 3)-linked-beta-D-glucopyranosyl residues, and nonreducing end beta-D-glucopyranosyl residues. An in vitro immunomodulating. activity assay revealed that GSP-6B could significantly induce the release of IL-1 beta and TNF-alpha in human peripheral blood mononuclear cell (PBMC) and showed no toxicity to either PBMC or a human macrophage cell line THP-1. GSP-6B could also activate dendritic cells (DC) by stimulating the secretion of IL-12 and IL-10 from DC.

语种英语
所属项目编号ITS/311/09 ; InP/108/10 ; FRG2/11-12/048 ; SEG CUHK08 ; CUHK09
资助者Government of the Hong Kong Special Administrative Region ; Hong Kong Baptist University ; University Grants Council of Hong Kong SAR ; Government of the Hong Kong Special Administrative Region ; Hong Kong Baptist University ; University Grants Council of Hong Kong SAR
WOS记录号WOS:000303362800014
引用统计
被引频次:39[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50559
专题北京大学药学院
作者单位1.Peking Univ, State Key Lab Nat & Biomimet Drugs, Sch Pharmaceut Sci, Hlth Sci Ctr, Beijing 100191, Peoples R China
2.Chinese Univ Hong Kong, State Key Lab Phytochem & Plant Resources W China, Inst Chinese Med, Shatin, Hong Kong, Peoples R China
3.Hong Kong Baptist Univ, Sch Chinese Med, Hong Kong, Hong Kong, Peoples R China
4.Chinese Univ Hong Kong, Sch Life Sci, Shatin, Hong Kong, Peoples R China
5.Chinese Univ Hong Kong, Ctr Prot Sci & Crystallog, Hong Kong, Hong Kong, Peoples R China
6.Tianjin Med Univ, Dept Pharmacol, Sch Basic Med Sci, Tianjin 300070, Peoples R China
7.Chinese Univ Hong Kong, Prince Wales Hosp, Dept Chem Pathol, Shatin, Hong Kong, Peoples R China
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GB/T 7714
Han, Xiao-Qiang,Chan, Ben Chung Lap,Dong, Cai-Xia,et al. Isolation, Structure Characterization, and Immunomodulating Activity of a Hyperbranched Polysaccharide from the Fruiting Bodies of Ganoderma sinense[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2012,60(17):4276-4281.
APA Han, Xiao-Qiang.,Chan, Ben Chung Lap.,Dong, Cai-Xia.,Yang, Yin-Hua.,Ko, Chun-Hay.,...&Han, Quan-Bin.(2012).Isolation, Structure Characterization, and Immunomodulating Activity of a Hyperbranched Polysaccharide from the Fruiting Bodies of Ganoderma sinense.JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,60(17),4276-4281.
MLA Han, Xiao-Qiang,et al."Isolation, Structure Characterization, and Immunomodulating Activity of a Hyperbranched Polysaccharide from the Fruiting Bodies of Ganoderma sinense".JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 60.17(2012):4276-4281.
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