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学科主题临床医学
Promoter hypermethylation of BCL6B gene is a potential plasma DNA biomarker for gastric cancer
Yang, Qingfan1,2,3,4,5; Gao, Jing6; Xu, Lixia1,2,3,4; Zeng, Zhirong5; Sung, Joseph J. Y.1,2,3,4; Yu, Jun1,2,3,4
关键词Bcl6b Biomarker Gastric Cancer Plasma Dna Promoter Methylation
刊名BIOMARKERS
2013-12-01
DOI10.3109/1354750X.2013.853839
18期:8页:721-725
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biotechnology & Applied Microbiology ; Toxicology
资助者National Basic Research Program of China (973 Program) ; National Natural Science Foundation of China ; Group Research Scheme CUHK ; National Basic Research Program of China (973 Program) ; National Natural Science Foundation of China ; Group Research Scheme CUHK
研究领域[WOS]Biotechnology & Applied Microbiology ; Toxicology
关键词[WOS]CPG ISLAND HYPERMETHYLATION ; CELL-FREE DNA ; BREAST-CANCER ; SERUM DNA ; METHYLATION ; TUMOR ; ANTIGEN
英文摘要

We previously showed that BCL6B acts as a tumor suppressor in gastric cancer and up to 66% gastric cancer patients have promoter hypermethylation in tumor tissues. We aimed to evaluate the feasibility of detecting BCL6B methylation in plasma DNA as a potential biomarker for gastric cancer. Hypermethylation of the CpG islands in BCL6B promoter was detected in 42.5% (17/40) plasma DNA samples from gastric cancer patients, while no methylation was found in the plasma DNA of healthy controls (p<0.001). BCL6B methylation may serve as a novel potential non-invasive plasma biomarker for the detection of gastric cancer.

语种英语
所属项目编号2010CB529305 ; 81172346 ; 3110043
资助者National Basic Research Program of China (973 Program) ; National Natural Science Foundation of China ; Group Research Scheme CUHK ; National Basic Research Program of China (973 Program) ; National Natural Science Foundation of China ; Group Research Scheme CUHK
WOS记录号WOS:000327504100012
引用统计
被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50560
专题北京大学临床肿瘤学院_胃肠肿瘤中心
作者单位1.Chinese Univ Hong Kong, Dept Med & Therapeut, Shatin, Hong Kong, Peoples R China
2.Chinese Univ Hong Kong, Li Ka Shing Inst Hlth Sci, State Key Lab Digest Dis, Shatin, Hong Kong, Peoples R China
3.Chinese Univ Hong Kong, Inst Digest Dis, Shatin, Hong Kong, Peoples R China
4.Chinese Univ Hong Kong, Shenzhen Res Inst, Shenzhen, Peoples R China
5.Sun Yat Sen Univ, Affiliated Hosp 1, Dept Gastroenterol, Guangzhou 510275, Guangdong, Peoples R China
6.Peking Univ, Canc Hosp & Inst, Dept Gastrointestinal Oncol, Minist Educ,Key Lab Carcinogenesis & Translat Res, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Yang, Qingfan,Gao, Jing,Xu, Lixia,et al. Promoter hypermethylation of BCL6B gene is a potential plasma DNA biomarker for gastric cancer[J]. BIOMARKERS,2013,18(8):721-725.
APA Yang, Qingfan,Gao, Jing,Xu, Lixia,Zeng, Zhirong,Sung, Joseph J. Y.,&Yu, Jun.(2013).Promoter hypermethylation of BCL6B gene is a potential plasma DNA biomarker for gastric cancer.BIOMARKERS,18(8),721-725.
MLA Yang, Qingfan,et al."Promoter hypermethylation of BCL6B gene is a potential plasma DNA biomarker for gastric cancer".BIOMARKERS 18.8(2013):721-725.
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