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学科主题: 临床医学
题名:
Human Telomerase RNA Gene Amplification Detection Increases the Specificity of Cervical Intraepithelial Neoplasia Screening
作者: Zheng, Lei1; Liu, Ai-Lan1; Qi, Tao1; Wang, Qian1; Cai, Zhen1; Su, Ya-Juan1; Hu, Yan-Wei1; Liu, Guo-Bing2; Wei, Li-Hui3
关键词: TERC ; FISH ; Human papillomavirus ; HC II ; Cervical intraepithelial neoplasia
刊名: INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
发表日期: 2010-08-01
DOI: 10.1111/IGC.0b013e3181e5c424
卷: 20, 期:6, 页:912-917
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology ; Obstetrics & Gynecology
研究领域[WOS]: Oncology ; Obstetrics & Gynecology
关键词[WOS]: HUMAN-PAPILLOMAVIRUS INFECTION ; SQUAMOUS-CELL CARCINOMAS ; CANCER ; DYSPLASIA ; LESIONS ; WOMEN ; TERC ; HPV ; DIAGNOSIS ; CYTOLOGY
英文摘要:

Objectives: The purpose of this study was to evaluate the clinical significance of genomic amplification of the human telomerase RNA gene (TERC) for cervical cancer screening and explore whether it can serve as a biomarker to improve the specificity of human papillomavirus (HPV) DNA testing for cervical cancer screening.

Methods: One hundred twenty women, including 20 cases of normal (control), 14 cases of cervical intraepithelial neoplasia grade I (CIN I), 35 cases of CIN II, 36 cases of CIN III, and 15 cases of squamous cervical cancer diagnosed by histopathologic evaluation, were subjected to cytopathologic examination, TERC detection by fluorescence in situ hybridization (FISH), and HPV DNA testing by Hybrid Capture II.

Results: TERC amplification was significantly associated with cytopathologic diagnosis (P < 0.001) and histopathologic evaluation (P < 0.001). The positive rate of TERC gain was significantly higher in patients with CIN III or squamous cervical cancer than in patients with CIN I or those in the control group (P < 0.001). The specificity and positive predictive value of FISH for detecting CIN II or more severe cervical lesions (>= CIN II) were obviously higher than those of HPV DNA testing (97.1% vs 52.9%, 98.7% vs 83.8%).

Conclusions: TERC amplification analyzed by FISH may serve as an adjunctive test to HPV DNA testing for improving the specificity and positive predictive value of cervical cancer screening.

语种: 英语
所属项目编号: WKJ 2007-3-001
项目资助者: Ministry of Health of the People&prime ; s Republic of China
WOS记录号: WOS:000280572000001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50567
Appears in Collections:北京大学第二临床医学院_妇科_期刊论文

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作者单位: 1.So Med Univ Guangzhou, Lab Med Ctr, Nanfang Hosp, Guangzhou 510515, Guangdong, Peoples R China
2.So Med Univ Guangzhou, Dept Gynecol, Nanfang Hosp, Guangzhou 510515, Guangdong, Peoples R China
3.Peking Univ, Peoples Hosp, Dept Gynecol, Beijing 100871, Peoples R China

Recommended Citation:
Zheng, Lei,Liu, Ai-Lan,Qi, Tao,et al. Human Telomerase RNA Gene Amplification Detection Increases the Specificity of Cervical Intraepithelial Neoplasia Screening[J]. INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER,2010,20(6):912-917.
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