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学科主题: 临床医学
题名:
Dasatinib inhibits primary melanoma cell proliferation through morphology-dependent disruption of Src-ERK signaling
作者: Wu, Jianghong1,2; Liao, Xin3; Yu, Bo4,5,6; Su, Bing3,5,6
关键词: melanoma ; Src ; ERK ; dasatinib ; U0126
刊名: ONCOLOGY LETTERS
发表日期: 2013-02-01
DOI: 10.3892/ol.2012.1066
卷: 5, 期:2, 页:527-532
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: TYROSINE KINASE INHIBITOR ; ACTIVATED PROTEIN-KINASE ; BREAST-CANCER CELLS ; GENE-EXPRESSION ; MAP KINASE ; V-SRC ; GROWTH ; INVASION ; PATHWAY ; TRANSDUCTION
英文摘要:

New strategies for the treatment of advanced melanoma are urgently required. The RAS/RAF/MAPK pathway and c-Src are deregulated in the majority of malignant melanomas, suggesting that they may interact functionally and are involved in the development and progression of the malignancy. Preclinical studies have demonstrated variable inhibition of melanoma cell growth by dasatinib in vitro. Src may act through different downstream signaling pathways. In the present study, we demonstrate that dasatinib induces changes in cell morphology, characterized by an arborized and contracted appearance, and accompanied by a reduction in cell proliferation in primary melanoma cells. This morphological change is demonstrated to be associated with the inhibition of nuclear translocation of activated ERK1/2. Together, these results indicate that Src may promote cell proliferation through the activation of the ERK signaling pathway in melanoma oncogenesis.

语种: 英语
所属项目编号: ZYA201106080030A
项目资助者: Research Grants of Shenzhen Science and Technology Project
WOS记录号: WOS:000313764400022
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50572
Appears in Collections:北京大学深圳医院_皮肤性病科_期刊论文

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作者单位: 1.Fudan Univ, Dept Gastr Canc & Soft Tissue Sarcoma Surg, Shanghai Canc Ctr, Shanghai 200032, Peoples R China
2.Fudan Univ, Shanghai Med Coll, Dept Oncol, Shanghai 200032, Peoples R China
3.Shenzhen PKU HKUST Med Ctr, Biomed Res Inst, Shenzhen 518036, Guangdong, Peoples R China
4.Peking Univ, Shenzhen Hosp, Dept Dermatol, Shenzhen, Peoples R China
5.Shenzhen PKU HKUST Med Ctr, Shenzhen Key Lab Translat Med Dermatol, Shenzhen 518036, Guangdong, Peoples R China
6.Peking Univ, Shenzhen Hosp, Shenzhen Key Discipline Dermatol, Shenzhen 518036, Guangdong, Peoples R China

Recommended Citation:
Wu, Jianghong,Liao, Xin,Yu, Bo,et al. Dasatinib inhibits primary melanoma cell proliferation through morphology-dependent disruption of Src-ERK signaling[J]. ONCOLOGY LETTERS,2013,5(2):527-532.
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