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Inhibition of platelet aggregation by polyaspartoyl L-arginine and its mechanism
Wang, YY1; Tang, ZY1; Dong, M1; Liu, XY1; Peng, SQ1
关键词Platelet Aggregation Bleeding Time Platelet Adhesiveness Polyaspartoyl L-arginine Nitric Oxide Cyclic Amp Thromboxane b(2) 6-ketoprostaglandin F1 Alpha
刊名ACTA PHARMACOLOGICA SINICA
2004-04-01
25期:4页:469-473
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Multidisciplinary ; Pharmacology & Pharmacy
研究领域[WOS]Chemistry ; Pharmacology & Pharmacy
关键词[WOS]NITRIC-OXIDE RELEASE
英文摘要

AIM: To observe the oral anti-platelet efficacy and the potential action mechanism of polyaspartoyl L-arginine (PDR), a new L-arginine rich compound. METHODS: Platelet aggregation was conducted by Born′s method; bleeding time was determined using tail′s bleeding time in mice; platelet adhesion was carried out with glass bottle method; nitric oxide (NO) was tested with Griess′ method; and cAMP, thromboxane B, (TXB,) and 6-keto-PGF(1alpha) were assessed with commercial kits. RESULTS: The inhibition by PDR (15-60 mg/kg ig or 10 mg/kg iv) of platelet aggregation induced by adenosine diphosphate (ADP), collagen or thrombin at 1 h after oral administration or at 20 min after iv injection for rats (P<0.01), and its (15 mg/kg, ig) inhibition of ADP-induced platelet aggregation for rabbits during 6 h after administration were observed. PDR (15-60 mg/kg) prolonged the bleeding time of mice (Pless than or equal to0.05) and (30 mg/kg) increased NO concentration in plasma. On the other hand PDR did not change the contents of cAMP in platelet and TXB, or 6-keto-PGF(1alpha) in plasma. CONCLUSION: PDR is a novel, oral effective platelet aggregation inhibitor and its action mechanism possibly related to increasing NO generation.

语种英语
WOS记录号WOS:000220750000012
引用统计
被引频次:16[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50576
专题北京大学药学院_分子与细胞药理学系
医学人文研究院/公共教学部_哲学与社会科学系
作者单位1.Peking Univ, Sch Pharmaceut Sci, Dept Pharmacol, Beijing 100083, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, Dept Med Chem, Beijing 100083, Peoples R China
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Wang, YY,Tang, ZY,Dong, M,et al. Inhibition of platelet aggregation by polyaspartoyl L-arginine and its mechanism[J]. ACTA PHARMACOLOGICA SINICA,2004,25(4):469-473.
APA Wang, YY,Tang, ZY,Dong, M,Liu, XY,&Peng, SQ.(2004).Inhibition of platelet aggregation by polyaspartoyl L-arginine and its mechanism.ACTA PHARMACOLOGICA SINICA,25(4),469-473.
MLA Wang, YY,et al."Inhibition of platelet aggregation by polyaspartoyl L-arginine and its mechanism".ACTA PHARMACOLOGICA SINICA 25.4(2004):469-473.
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