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IR@PKUHSC  > 北京大学药学院  > 分子与细胞药理学系  > 期刊论文
学科主题: 药学
题名:
Inhibition of platelet aggregation by polyaspartoyl L-arginine and its mechanism
作者: Wang, YY1; Tang, ZY1; Dong, M1; Liu, XY1; Peng, SQ1
关键词: platelet aggregation ; bleeding time ; platelet adhesiveness ; polyaspartoyl L-arginine ; nitric oxide ; cyclic AMP ; thromboxane B(2) ; 6-ketoprostaglandin F1 alpha
刊名: ACTA PHARMACOLOGICA SINICA
发表日期: 2004-04-01
卷: 25, 期:4, 页:469-473
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Multidisciplinary ; Pharmacology & Pharmacy
研究领域[WOS]: Chemistry ; Pharmacology & Pharmacy
关键词[WOS]: NITRIC-OXIDE RELEASE
英文摘要:

AIM: To observe the oral anti-platelet efficacy and the potential action mechanism of polyaspartoyl L-arginine (PDR), a new L-arginine rich compound. METHODS: Platelet aggregation was conducted by Born′s method; bleeding time was determined using tail′s bleeding time in mice; platelet adhesion was carried out with glass bottle method; nitric oxide (NO) was tested with Griess′ method; and cAMP, thromboxane B, (TXB,) and 6-keto-PGF(1alpha) were assessed with commercial kits. RESULTS: The inhibition by PDR (15-60 mg/kg ig or 10 mg/kg iv) of platelet aggregation induced by adenosine diphosphate (ADP), collagen or thrombin at 1 h after oral administration or at 20 min after iv injection for rats (P<0.01), and its (15 mg/kg, ig) inhibition of ADP-induced platelet aggregation for rabbits during 6 h after administration were observed. PDR (15-60 mg/kg) prolonged the bleeding time of mice (Pless than or equal to0.05) and (30 mg/kg) increased NO concentration in plasma. On the other hand PDR did not change the contents of cAMP in platelet and TXB, or 6-keto-PGF(1alpha) in plasma. CONCLUSION: PDR is a novel, oral effective platelet aggregation inhibitor and its action mechanism possibly related to increasing NO generation.

语种: 英语
WOS记录号: WOS:000220750000012
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50576
Appears in Collections:北京大学药学院_分子与细胞药理学系_期刊论文

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作者单位: 1.Peking Univ, Sch Pharmaceut Sci, Dept Pharmacol, Beijing 100083, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, Dept Med Chem, Beijing 100083, Peoples R China

Recommended Citation:
Wang, YY,Tang, ZY,Dong, M,et al. Inhibition of platelet aggregation by polyaspartoyl L-arginine and its mechanism[J]. ACTA PHARMACOLOGICA SINICA,2004,25(4):469-473.
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