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学科主题: 临床医学
题名:
PRSS3 expression is associated with tumor progression and poor prognosis in epithelial ovarian cancer
作者: Ma, Ruiqiong; Ye, Xue; Cheng, Hongyan; Ma, Yu; Cui, Heng; Chang, Xiaohong
关键词: Epithelial ovarian cancer ; PRSS3 ; Survival ; Prognostic marker
刊名: GYNECOLOGIC ONCOLOGY
发表日期: 2015-06-01
DOI: 10.1016/j.ygyno.2015.02.022
卷: 137, 期:3, 页:546-552
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology ; Obstetrics & Gynecology
研究领域[WOS]: Oncology ; Obstetrics & Gynecology
关键词[WOS]: PROTEASE-ACTIVATED RECEPTOR-2 ; INHIBITOR RESISTANCE ; CELL-PROLIFERATION ; TRYPSIN-INHIBITOR ; HUMAN MESOTRYPSIN ; BREAST-CANCER ; COLON-CANCER ; METASTASIS ; GROWTH ; BRAIN
英文摘要:

Objective. PRSS3 is an atypical isoform of trypsin that has been associated with breast, lung, and pancreatic cancers. This study aimed to elucidate the role of PRSS3 in tumor tissues of patients with epithelial ovarian cancer (EOC) and to investigate the prognostic value of this marker.

Methods. PRSS3 expression was evaluated by immunohistochemistry and real-time PCR (RT-PCR) in ovarian cancers, benign ovarian tumors and the ovaries of age-matched normal patients. Correlations between clinicopathologic variables and PRSS3 expression in EOC tissues and the prognostic value of PRSS3 for progression-free survival (PFS) and overall survival (OS) were evaluated.

Results. PRSS3 expression was significantly elevated in EOC tissues compared to benign ovarian tumors and normal ovarian controls at both the mRNA and protein levels. There was a good correlation between the PRSS3 expression levels measured by the two different techniques. High PRSS3 expression in EOC tissues was significantly associated with advanced FIGO stage and lymph node metastasis. In a univariate survival analysis of the ovarian carcinoma cohort, positive expression of PRSS3 was significantly associated with shortened patient survival. Importantly, PRSS3 expression was a significant independent prognostic parameter in the multivariate analysis.

Conclusions. These findings indicate that PRSS3 overexpression can be used as a predictor of clinical outcome in patients with ovarian cancer and may therefore represent a new prognostic marker. (C) 2015 Elsevier Inc. All rights reserved.

语种: 英语
所属项目编号: 81101951 ; 2012AA02A507
项目资助者: National Science Foundation for Young Scientists of China ; National High Technology Research and Development Program of China (863 Program)
WOS记录号: WOS:000355779000030
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50578
Appears in Collections:北京大学第二临床医学院_妇科肿瘤中心_期刊论文

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作者单位: Peking Univ, Peoples Hosp, Gynecol Oncol Ctr, Beijing 100044, Peoples R China

Recommended Citation:
Ma, Ruiqiong,Ye, Xue,Cheng, Hongyan,et al. PRSS3 expression is associated with tumor progression and poor prognosis in epithelial ovarian cancer[J]. GYNECOLOGIC ONCOLOGY,2015,137(3):546-552.
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