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学科主题: 精神卫生
题名:
Association Study of Serotonin Transporter Gene Polymorphisms with Obstructive Sleep Apnea Syndrome in Chinese Han Population
作者: Yue, Weihua1,2; Liu, Huiguo3; Zhang, Jishui4; Zhang, Xianghui2; Wang, Xiaoping2; Liu, Tieqiao2; Liu, Pozi2,5; Hao, Wei1,2
关键词: Obstructive sleep apnea syndrome (OSAS) ; serotonin transporter (5-HTT) ; association study
刊名: SLEEP
发表日期: 2008-11-01
卷: 31, 期:11, 页:1535-1541
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Clinical Neurology ; Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: EXTRACELLULAR SEROTONIN ; AFFECTIVE-DISORDERS ; HYPOPNEA SYNDROME ; SUSCEPTIBILITY ; SYMPTOMATOLOGY ; EPIDEMIOLOGY ; AGGREGATION ; INHERITANCE ; PERFORMANCE ; SYMPTOMS
英文摘要:

Background: Since the serotonin (5-HT) is associated with circadian rhythm and breathing regulation, the serotonin transporter (5-HTT), which plays an important role in serotoninergic transmission, might be a strong candidate gene in the pathogenesis of obstructive sleep apnea syndrome (OSAS).

Objective: To investigate the association of 5-HTT gene polymorphisms with OSAS and clinical characteristics.

Methods: We genotyped the 5-HTT gene linked polymorphic region (5-HTTLPR) and a variable number of tandem repeats at intron 2 (STin2.VNTR) in 254 OSAS patients and 338 healthy controls in Chinese Han population.

Results: In total sample, the 10-repeat allele of STin2.VNTR was significantly associated with OSAS (P = 0.007, OR = 1.72, 95% Cl = 1.15-2.58), but no association was found in 5-HTTLPR. In male subjects, both polymorphisms showed significant association with OSAS (Allele L: P 0.005, OR = 1.44, 95% Cl = 1.11 to 1.87; Allele 10: P = 0.002, OR 1.94, 95% Cl = 1.26 to 3.00). Two haplotypes, S-12 and L-10, constructed by the above polymorphisms also revealed significant associations with OSAS (global P-values were 0.020 for total sample and 0.0006 for male subjects, respectively). Male patients carrying the haplotype S-12 showed a significantly lower apnea / hypopnea index (AHI), depressive factor, plasma 5-HT level and 5-hydroxyindolacetic acid (5-HIAA) levels, but higher episodic memory, when compared with non-S-12 carriers (P < 0.05). However, no significant differences were found in excessive daytime sleepiness or other psychological function across haplotype carriers (P > 0.05).

Conclusions: These findings support that 5-HTT gene may be involved in susceptibility to OSAS, especially with sex-dependent effect.

语种: 英语
WOS记录号: WOS:000260550100012
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50580
Appears in Collections:北京大学精神卫生研究所_期刊论文

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作者单位: 1.Cent S Univ, Xiangya Hosp 2, Mental Hlth Inst, Changsha 410011, Hunan, Peoples R China
2.Peking Univ, Inst Mental Hlth, Minist Hlth, Key Lab Mental Hlth, Beijing 100871, Peoples R China
3.Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Wuhan 430074, Peoples R China
4.Capital Univ Med Sci, Beijing Childrens Hosp, Beijing, Peoples R China
5.Tsinghua Univ, Affiliated Hosp 2, Beijing 100084, Peoples R China

Recommended Citation:
Yue, Weihua,Liu, Huiguo,Zhang, Jishui,et al. Association Study of Serotonin Transporter Gene Polymorphisms with Obstructive Sleep Apnea Syndrome in Chinese Han Population[J]. SLEEP,2008,31(11):1535-1541.
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