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学科主题: 临床医学
题名:
Interaction between Microbes and Host Intestinal Health: Modulation by Dietary Nutrients and Gut-Brain-Endocrine-Immune Axis
作者: Chen, Jingshu1; Li, Yuan2; Tian, Yanan3; Huang, Chang1; Li, Defa1; Zhong, Qing4; Ma, Xi1,4
关键词: Gut-brain-endocrine-immune axis ; Intestine ; Metabolism ; Microbes ; Nutrients ; Reactions
刊名: CURRENT PROTEIN & PEPTIDE SCIENCE
发表日期: 2015
DOI: 10.2174/1389203716666150630135720
卷: 16, 期:7, 页:592-603
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology
研究领域[WOS]: Biochemistry & Molecular Biology
关键词[WOS]: CHAIN FATTY-ACIDS ; PROTEIN-COUPLED RECEPTOR ; SEGMENTED FILAMENTOUS BACTERIA ; WHITE ADIPOSE-TISSUE ; REGULATORY T-CELLS ; GERM-FREE-MICE ; ADAPTIVE IMMUNITY ; DENDRITIC CELLS ; INDUCED OBESITY ; BILE-ACID
英文摘要:

The mammalian gut, the site of digestion and nutrients absorption, harbors diverse microbes that play an essential role in maintaining physiological homeostasis of the gastrointestinal system. These commensal microbes are important for the normal development of the host immune system and alteration of the microbiota of gastrointestinal system has been found to play an important role in the development of obesity, metabolic syndromes such as type 2 diabetes, and cardiovascular diseases. Several recent studies with mouse models and in humans have demonstrated that intestinal microbiota has important role in host metabolism by regulating energy absorption and modulating the endocrine functions. A variety of nutrients and metabolites derived from commensal bacteria have been proved to be important regulators in improving gut barrier functions and immune homeostasis. Here we review current literature on the interactions between microbes and host in the Gastrointestinal (GI) tract and based on these interactions we proposed a hypothesis in which the microbiota interacts with the host gastrointestine through a gut-brain-endocrine-immune system. By understanding this system, we should be in better position to develop treatment for metabolic diseases and inflammation in human and animals.

语种: 英语
所属项目编号: 2013CB117303 ; 201403047 ; 31272448 ; xx2013055 ; 2014JD017
项目资助者: National Basic Research Program of China (973 Program) ; National Department Public Benefit Research Foundation ; National Natural Science Foundation of China ; Beijing Nova program ; Chinese Universities Scientific Fund
WOS记录号: WOS:000359432300004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50581
Appears in Collections:北京大学第三临床医学院_消化科_期刊论文

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作者单位: 1.Peking Univ, Hosp 3, Dept Gastroenterol, Beijing 100191, Peoples R China
2.Univ Texas SW Med Ctr Dallas, Dept Internal Med, Ctr Autophagy Res, Dallas, TX 75390 USA
3.China Agr Univ, State Key Lab Anim Nutr, Beijing 100193, Peoples R China
4.Texas A&M Univ, Dept Vet Physiol & Pharmacol, College Stn, TX 77843 USA

Recommended Citation:
Chen, Jingshu,Li, Yuan,Tian, Yanan,et al. Interaction between Microbes and Host Intestinal Health: Modulation by Dietary Nutrients and Gut-Brain-Endocrine-Immune Axis[J]. CURRENT PROTEIN & PEPTIDE SCIENCE,2015,16(7):592-603.
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