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学科主题基础医学
Spontaneous conversion between mutL and 6 bp Delta mutL in Salmonella typhimurium LT7: Association with genome diversification and possible roles in bacterial adaptation
Gong, Jun1; Liu, Wei-Qiao1; Liu, Gui-Rong1; Chen, Fang1; Li, Jun-Qian1; Xu, Guo-Min1; Wang, Ling1; Johnston, Randal N.1; Eisenstark, Abraham1; Liu, Shu-Lin1
关键词mutL Salmonella genome diversification bacterial adaptation mutator
刊名GENOMICS
2007-10-01
DOI10.1016/j.ygeno.2007.06.009
90期:4页:542-549
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biotechnology & Applied Microbiology ; Genetics & Heredity
研究领域[WOS]Biotechnology & Applied Microbiology ; Genetics & Heredity
关键词[WOS]DNA MISMATCH REPAIR ; ESCHERICHIA-COLI MUTS ; MUTATION-RATES ; ENTERICA ; TYPHI ; SEQUENCE ; PROTEINS ; REARRANGEMENTS ; RECOMBINATION ; POPULATIONS
英文摘要

Previously, we reported the phenomenon of genome diversification in Salmonella typhimurium LT7, i.e., individual strains derived from LT7 kept changing the genome structure by inversions, translocations, duplications, and mutations. To elucidate the genetic basis, we sequenced selected genes of the mismatch repair (MMR) system for correlations between MMR defects and genome diversification. We chose S. typhimurium LT7 mutants 8111F2 and 9052D1 for mut gene sequence analyses and found that both mutants had a deletion of one of three tandem 6-bp repeats, GCTGGC GCTGGC GCTGGC, within mutL, which was designated 6 bp Delta mutL. mutS and mutH genes were unchanged in the mutants analyzed. Some sublines of 8111F2 and 9052D1 spontaneously stopped the genome diversification process at certain stages during single-colony restreaking passages, and in these strains the 6 bp Delta mutL genotype also became wild-type mutL. We conclude that conversion between mutL and 6 bp Delta mutL occurs spontaneously and that transient defects of mutL facilitate genome diversification without leading to the accumulation of multiple detrimental genetic changes. Spontaneous conversion between mutL and 6 bp Delta mutL may be an important mechanism used by bacteria to regulate genetic stability in adaptation to changing environments. (C) 2007 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000249990500012
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被引频次:15[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
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条目标识符http://ir.bjmu.edu.cn/handle/400002259/50596
专题北京大学基础医学院_病原生物学系
北京大学基础医学院
作者单位1.Peking Univ, Dept Microbiol, Hlth Sci Ctr, Beijing 100083, Peoples R China
2.Univ Calgary, Dept Microbiol & Infect Dis, Calgary, AB T2N 4N1, Canada
3.Univ Calgary, Dept Biochem & Mol Biol, Calgary, AB T2N 4N1, Canada
4.Univ Missouri, Canc Res Ctr, Columbia, MO 65211 USA
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Gong, Jun,Liu, Wei-Qiao,Liu, Gui-Rong,et al. Spontaneous conversion between mutL and 6 bp Delta mutL in Salmonella typhimurium LT7: Association with genome diversification and possible roles in bacterial adaptation[J]. GENOMICS,2007,90(4):542-549.
APA Gong, Jun.,Liu, Wei-Qiao.,Liu, Gui-Rong.,Chen, Fang.,Li, Jun-Qian.,...&Liu, Shu-Lin.(2007).Spontaneous conversion between mutL and 6 bp Delta mutL in Salmonella typhimurium LT7: Association with genome diversification and possible roles in bacterial adaptation.GENOMICS,90(4),542-549.
MLA Gong, Jun,et al."Spontaneous conversion between mutL and 6 bp Delta mutL in Salmonella typhimurium LT7: Association with genome diversification and possible roles in bacterial adaptation".GENOMICS 90.4(2007):542-549.
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