学科主题临床医学
Peritumoural neutrophils negatively regulate adaptive immunity via the PD-L1/PD-1 signalling pathway in hepatocellular carcinoma
He, Gaixia1,2; Zhang, Henghui1,2,4,5; Zhou, Jinxue3; Wang, Beibei4,5; Chen, Yanhui1,2; Kong, Yaxian4,5; Xie, Xingwang1,2; Wang, Xueyan1,2; Fei, Ran1,2; Wei, Lai1,2; Chen, Hongsong1,2; Zeng, Hui4,5
关键词Neutrophils Hepatocellular Carcinoma Predictive Value Programmed Death Ligand 1
刊名JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
2015-11-18
DOI10.1186/s13046-015-0256-0
34
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]TUMOR-ASSOCIATED NEUTROPHILS ; TO-LYMPHOCYTE RATIO ; CANCER ; BLOCKADE ; PD-1 ; THERAPY ; MICROENVIRONMENT ; OVEREXPRESSION ; RECURRENCE ; PREDICTOR
英文摘要

Background: PD-L1 expression on neutrophils contributes to the impaired immune response in infectious disease, but the detailed role of PD-L1 expression on neutrophils in HCC remains unclear.

Methods: We investigated the phenotype and morphology of neutrophils infiltrated in tumour tissues from both patients with HCC and hepatoma-bearing mice.

Results: We found that neutrophils dominantly infiltrated in the peritumoural region. The neutrophil-to-T cell ratio (NLR) was higher in peritumoural tissue than that in the intratumoural tissue and was negatively correlated with the overall survival of patients with HCC. Infiltrating neutrophils displayed a phenotype of higher frequency of programmed cell death ligand 1 (PD-L1) positive neutrophils. The ratio of PD-L1(+) neutrophils-to-PD-1(+) T cells was higher in peritumoural tissue and better predicted the disease-free survival of patients with HCC. We further confirmed a higher frequency of PD-L1(+) neutrophils and PD-1(+) T cells in hepatoma-bearing mice. Functionally, the PD-L1(+) neutrophils from patients with HCC effectively suppressed the proliferation and activation of T cells, which could be partially reversed by the blockade of PD-L1.

Conclusions: Our results indicate that the tumour microenvironment induces impaired antitumour immunity via the modulation of PD-L1 expression on tumour infiltrating neutrophils.

语种英语
WOS记录号WOS:000366491500001
项目编号91029741 ; 81171550 ; 81001072 ; 2012ZX10002011-006 ; 7152151
资助机构National Natural Science Foundation of China ; National Key Sci-Tech Special Project of China ; Beijing Natural Science Foundation
引用统计
被引频次:22[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50597
专题北京大学第二临床医学院_北京大学肝病研究所
作者单位1.Beijing Key Lab Emerging Infect Dis, Beijing 100015, Peoples R China
2.Peking Univ, Peoples Hosp, Inst Hepatol, Beijing 100044, Peoples R China
3.Beijing Key Lab Hepatitis C & Immunotherapy Liver, Beijing 100044, Peoples R China
4.Henan Tumour Hosp, Dept Hepatobiliary & Pancreat Surg, Zhengzhou 450008, Henan, Peoples R China
5.Capital Med Univ, Beijing Ditan Hosp, Inst Infect Dis, Beijing 100015, Peoples R China
推荐引用方式
GB/T 7714
He, Gaixia,Zhang, Henghui,Zhou, Jinxue,et al. Peritumoural neutrophils negatively regulate adaptive immunity via the PD-L1/PD-1 signalling pathway in hepatocellular carcinoma[J]. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH,2015,34.
APA He, Gaixia.,Zhang, Henghui.,Zhou, Jinxue.,Wang, Beibei.,Chen, Yanhui.,...&Zeng, Hui.(2015).Peritumoural neutrophils negatively regulate adaptive immunity via the PD-L1/PD-1 signalling pathway in hepatocellular carcinoma.JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH,34.
MLA He, Gaixia,et al."Peritumoural neutrophils negatively regulate adaptive immunity via the PD-L1/PD-1 signalling pathway in hepatocellular carcinoma".JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH 34(2015).
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