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学科主题: 临床医学
题名:
Effects of diffusion time and diffusion gradient strength on the mean diffusivity of water molecules in healthy human brain
作者: Gao Song1; Wang Xiaoying1; Bao Shanglian1
关键词: diffusion time ; diffusion gradient strength ; diffusion-weighted imaging ; diffusion tensor imaging ; mean diffusivity
刊名: PROGRESS IN NATURAL SCIENCE
发表日期: 2006-07-01
卷: 16, 期:7, 页:706-711
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Materials Science, Multidisciplinary ; Multidisciplinary Sciences
研究领域[WOS]: Materials Science ; Science & Technology - Other Topics
关键词[WOS]: WHITE-MATTER ; SELF-DIFFUSION ; TENSOR ; ECHO ; NMR ; COEFFICIENT ; IMAGES
英文摘要:

Diffusion time and diffusion gradient strength are two important parameters of pulsed gradient spin echo (PGSE) that is the most commonly used method in diffusion-weighted magnetic resonance imaging. However, the effects of the diffusion time on the mean diffusivity (MD) in previous studies are controversial. In this study, a new experimental protocol was designed to evaluate the effects of the two parameters on the results of PGSE. It was found that MD decreased significantly with the increased diffusion time or increased diffusion gradient strength, which cannot be explained by the previous theories. Through theoretical analysis, we found the flaw in the pulsed gradient spin echo (PGSE) method, which is the explanation for the controversial results of diffusion time obtained by others.

语种: 英语
WOS记录号: WOS:000239697500006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50599
Appears in Collections:北京大学第一临床医学院_放射治疗科_期刊论文

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作者单位: 1.Peking Univ, Lab Med Phys & Engn, Beijing 100871, Peoples R China
2.Peking Univ, Affiliated Hosp 1, Dept Radiol, Beijing 100034, Peoples R China

Recommended Citation:
Gao Song,Wang Xiaoying,Bao Shanglian. Effects of diffusion time and diffusion gradient strength on the mean diffusivity of water molecules in healthy human brain[J]. PROGRESS IN NATURAL SCIENCE,2006,16(7):706-711.
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