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学科主题: 临床医学
题名:
Galectin-9 in Combination With EX-527 Prolongs the Survival of Cardiac Allografts in Mice After Cardiac Transplantation
作者: Tao, Y. -F.1,2; Lin, F.3; Yan, X. -Y.4; Gao, X. -G.5; Teng, F.5; Fu, Z. -R.5; Wang, Z. -X.1,2
刊名: TRANSPLANTATION PROCEEDINGS
发表日期: 2015-07-01
DOI: 10.1016/j.transproceed.2015.04.091
卷: 47, 期:6, 页:2003-2009
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Immunology ; Surgery ; Transplantation
研究领域[WOS]: Immunology ; Surgery ; Transplantation
关键词[WOS]: ACUTE REJECTION ; TH17 CELLS ; LIVER-TRANSPLANTATION ; INNATE IMMUNITY ; TIM-3 LIGAND ; INDUCTION ; ALLOIMMUNITY ; INFLAMMATION ; LYMPHOCYTES ; SUPPRESSES
英文摘要:

Galectin-9 (Gal-9), a member of the galectin family, has a variety of biologic activities. However, its role in allografts is not fully clarified yet. The relationship between interleukin-17 (IL-17) and Gal-9 and the role of Gal-9 in T(H)17-cell differentiation also remain unclear. We built a murine cardiac transplantation model, which we treated with Gal-9 and/or EX-527, a specific Sirtuin-1 inhibitor. Afterwards, flow-cytometric analysis and reverse-transcription polymerase chain reaction were used to detect the number of T(H)17 cells and the expression of key factors involved in the differentiation of T(H)17 cells; in addition, the survival times of cardiac transplanted mice in different groups were recorded. The levels of circulating T(H)17 cells were found to increase in the peripheral blood of mice that exhibited acute rejection (AR) after heart transplantation, which was determined to be correlated with the rejection grade. Gal-9 or EX-527 can inhibit the activation and differentiation of T(H)17 cells and effectively suppress T(H)17-cell-mediated AR. These data provide new evidence for the potential regulatory effects of Gal-9 in alloimmune responses in a murine model of heart transplantation, and suggest the combined use of galectin-9 and EX-527 may be a powerful method to induce tolerance of fully mismatched murine cardiac allografts.

语种: 英语
所属项目编号: 81001327 ; 11410708700 ; 11ZR1448100
项目资助者: National Natural Science Foundation of China ; International Science and Technology Cooperation Foundation of Shanghai ; Natural Science Foundation of Shanghai
WOS记录号: WOS:000360776700079
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50604
Appears in Collections:北京大学临床研究所_期刊论文

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作者单位: 1.Fudan Univ, Huashan Hosp, Dept Gen Surg, Shanghai 200040, Peoples R China
2.Fudan Univ, Huashan Hosp, Liver Transplant Ctr, Shanghai 200040, Peoples R China
3.Taizhou First Peoples Hosp, Dept Gen Surg, Taizhou, Zhejiang, Peoples R China
4.Peking Univ, Clin Res Inst, Hlth Sci Ctr, Beijing 100871, Peoples R China
5.Second Mil Med Univ, Changzheng Hosp, Div Liver Transplantat, Organ Transplant Ctr, Shanghai, Peoples R China

Recommended Citation:
Tao, Y. -F.,Lin, F.,Yan, X. -Y.,et al. Galectin-9 in Combination With EX-527 Prolongs the Survival of Cardiac Allografts in Mice After Cardiac Transplantation[J]. TRANSPLANTATION PROCEEDINGS,2015,47(6):2003-2009.
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