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学科主题: 临床医学
题名:
Sulfur dioxide restores calcium homeostasis disturbance in rat with isoproterenol-induced myocardial injury
作者: Chen, Shanshan1; Du, Junbao1,2; Liang, Yinfang1; Zhang, Rongyuan1; Tang, Chaoshu2,3; Jin, Hongfang1
关键词: Sulfur dioxide ; Isoproterenol ; Myocardial injury ; Calcium homeostasis
刊名: HISTOLOGY AND HISTOPATHOLOGY
发表日期: 2012-09-01
卷: 27, 期:9, 页:1219-1226
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cell Biology ; Pathology
研究领域[WOS]: Cell Biology ; Pathology
关键词[WOS]: CARDIOVASCULAR-SYSTEM ; AIR-POLLUTION ; DERIVATIVES ; CARDIOMYOCYTES ; MODULATION ; INFARCTION ; OVERLOAD ; PROTECTS ; HEART
英文摘要:

Backgrounds: sulfur dioxide (SO2) could relieve isoproterenol (ISO)-induced myocardial injury, while the mechanism is unclear. This study aims to explore whether the protective effect of SO2 on ISO-induced myocardial injury was mediated by the restoration of calcium homeostasis disturbance in cardiomyocyte. Methods and results: Rats were randomly divided into four groups: ISO group, ISO+SO2 group, control group and SO2 group. Content of Ca2+ in H9c2 cells was assayed using confocal microscope, and cardiac function parameters were measured by echocardiography. Plasma biochemical values and myocardial ultra-structure changes were measured. Meanwhile, the activity, protein and gene levels of sarcoplasmic reticulum Ca2+ ATPase (SERCA), and protein and phosphorylation of phospholamban (PLN) were detected. We found SO2 derivatives could restore the decreased cardiac function, the abnormal lactate dehydrogenase, creatine kinase, alpha-hydroxybutyrate dehydrogenase, potassium, calcium, blood urea nitrogen and the damaged myocardial ultra-structure in rats, and regulate the increased Ca2+ content in H9c2 induced by ISO. In addition, compared with ISO group, the decreased activities, protein and mRNA level of SERCA, as well as the decreased protein phosphorylation level of PLN in myocardial tissues were increased in ISO+SO2 group. Conclusion: SO2 derivatives might relieve calcium overload in association with the upregulating expression of SERCA and p-PLN/PLN by myocardial tissues in rats with ISO-induced myocardial injury.

语种: 英语
所属项目编号: 2011CB503904 ; 2012CB517806 ; 81070111 ; 30821001 ; 7112130
项目资助者: Major State Basic Research Development Program ; National Natural Science Foundation of China ; Natural Science Foundation of Beijing
WOS记录号: WOS:000306521400011
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50609
Appears in Collections:北京大学第一临床医学院_儿科_期刊论文

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作者单位: 1.Peking Univ, Hosp 1, Dept Pediat, Beijing 100034, Peoples R China
2.Minist Educ, Key Lab Mol Cardiol, Beijing, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Dept Physiol & Pathophysiol, Beijing 100034, Peoples R China

Recommended Citation:
Chen, Shanshan,Du, Junbao,Liang, Yinfang,et al. Sulfur dioxide restores calcium homeostasis disturbance in rat with isoproterenol-induced myocardial injury[J]. HISTOLOGY AND HISTOPATHOLOGY,2012,27(9):1219-1226.
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