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学科主题临床医学
Sulfur dioxide restores calcium homeostasis disturbance in rat with isoproterenol-induced myocardial injury
Chen, Shanshan1; Du, Junbao1,2; Liang, Yinfang1; Zhang, Rongyuan1; Tang, Chaoshu2,3; Jin, Hongfang1
关键词Sulfur Dioxide Isoproterenol Myocardial Injury Calcium Homeostasis
刊名HISTOLOGY AND HISTOPATHOLOGY
2012-09-01
27期:9页:1219-1226
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cell Biology ; Pathology
研究领域[WOS]Cell Biology ; Pathology
关键词[WOS]CARDIOVASCULAR-SYSTEM ; AIR-POLLUTION ; DERIVATIVES ; CARDIOMYOCYTES ; MODULATION ; INFARCTION ; OVERLOAD ; PROTECTS ; HEART
英文摘要

Backgrounds: sulfur dioxide (SO2) could relieve isoproterenol (ISO)-induced myocardial injury, while the mechanism is unclear. This study aims to explore whether the protective effect of SO2 on ISO-induced myocardial injury was mediated by the restoration of calcium homeostasis disturbance in cardiomyocyte. Methods and results: Rats were randomly divided into four groups: ISO group, ISO+SO2 group, control group and SO2 group. Content of Ca2+ in H9c2 cells was assayed using confocal microscope, and cardiac function parameters were measured by echocardiography. Plasma biochemical values and myocardial ultra-structure changes were measured. Meanwhile, the activity, protein and gene levels of sarcoplasmic reticulum Ca2+ ATPase (SERCA), and protein and phosphorylation of phospholamban (PLN) were detected. We found SO2 derivatives could restore the decreased cardiac function, the abnormal lactate dehydrogenase, creatine kinase, alpha-hydroxybutyrate dehydrogenase, potassium, calcium, blood urea nitrogen and the damaged myocardial ultra-structure in rats, and regulate the increased Ca2+ content in H9c2 induced by ISO. In addition, compared with ISO group, the decreased activities, protein and mRNA level of SERCA, as well as the decreased protein phosphorylation level of PLN in myocardial tissues were increased in ISO+SO2 group. Conclusion: SO2 derivatives might relieve calcium overload in association with the upregulating expression of SERCA and p-PLN/PLN by myocardial tissues in rats with ISO-induced myocardial injury.

语种英语
WOS记录号WOS:000306521400011
项目编号2011CB503904 ; 2012CB517806 ; 81070111 ; 30821001 ; 7112130
资助机构Major State Basic Research Development Program ; National Natural Science Foundation of China ; Natural Science Foundation of Beijing
引用统计
被引频次:12[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50609
专题北京大学第一临床医学院_儿科
北京大学临床肿瘤学院_移植与免疫治疗病区
作者单位1.Peking Univ, Hosp 1, Dept Pediat, Beijing 100034, Peoples R China
2.Minist Educ, Key Lab Mol Cardiol, Beijing, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Dept Physiol & Pathophysiol, Beijing 100034, Peoples R China
推荐引用方式
GB/T 7714
Chen, Shanshan,Du, Junbao,Liang, Yinfang,et al. Sulfur dioxide restores calcium homeostasis disturbance in rat with isoproterenol-induced myocardial injury[J]. HISTOLOGY AND HISTOPATHOLOGY,2012,27(9):1219-1226.
APA Chen, Shanshan,Du, Junbao,Liang, Yinfang,Zhang, Rongyuan,Tang, Chaoshu,&Jin, Hongfang.(2012).Sulfur dioxide restores calcium homeostasis disturbance in rat with isoproterenol-induced myocardial injury.HISTOLOGY AND HISTOPATHOLOGY,27(9),1219-1226.
MLA Chen, Shanshan,et al."Sulfur dioxide restores calcium homeostasis disturbance in rat with isoproterenol-induced myocardial injury".HISTOLOGY AND HISTOPATHOLOGY 27.9(2012):1219-1226.
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