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学科主题: 临床医学
题名:
Topical application of a Chinese medicine, Qingpeng ointment, ameliorates 2, 4-dinitrofluorobenzene-induced allergic contact dermatitis in BALB/c mice
作者: Li, Yuanyuan; Li, Lin-Feng
关键词: Allergic contact dermatitis ; dinitrofluorobenzene ; mouse ; Qingpeng ointment ; traditional Chinese medicine
刊名: EUROPEAN JOURNAL OF DERMATOLOGY
发表日期: 2013-11-01
DOI: 10.1684/ejd.2013.2185
卷: 23, 期:6, 页:803-806
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Dermatology
研究领域[WOS]: Dermatology
英文摘要:

Background: Qingpeng ointment (QP) is a traditional Chinese medicine which has been used for treatment of eczema in China. However, the mechanisms of its anti-inflammatory activities are not known. Objectives: To assess the anti-inflammatory effects of QP using a mouse model of allergic contact dermatitis, compare the effects with mometasone furoate cream (MF), and to relate the effects to modulation of inflammatory cytokines. Methods: Persistent dermatitis was induced in BALB/c mice using dinitrofluorobenzene. Topical treatment, including the vehicle of QP, 50%, 75%, 100% QP in vehicle, and MF was applied for 14 days. Dermatitis was evaluated macroscopically and microscopically at day 8 and day 15 after treatment. The levels of IL1B, IL2, TNFA, IFNG in both sera and skin tissue were detected with Enzyme-Linked Immunosorbent Assay (ELISA). Results: Significant reductions of skin inflammation in mice skin were observed after treatment with QP and MF, but not with the vehicle of QP. Similar to MF, QP also suppressed the expression of IL1B, IL2, TNFA and IFNG. Conclusion: This study demonstrates that QP inhibits allergic contact dermatitis in mice, similar to MF. QP suppresses the expression of Th1 cytokines in both sera and skin tissue, by which it may exert its anti-inflammatory effects.

语种: 英语
项目资助者: Chinese Association of the Integration of Traditional and Western Medicine
WOS记录号: WOS:000331460000007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/50610
Appears in Collections:北京大学第三临床医学院_皮肤科_期刊论文

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作者单位: Peking Univ, Hosp 3, Dept Dermatol, Beijing 100191, Peoples R China

Recommended Citation:
Li, Yuanyuan,Li, Lin-Feng. Topical application of a Chinese medicine, Qingpeng ointment, ameliorates 2, 4-dinitrofluorobenzene-induced allergic contact dermatitis in BALB/c mice[J]. EUROPEAN JOURNAL OF DERMATOLOGY,2013,23(6):803-806.
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