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Topical application of a Chinese medicine, Qingpeng ointment, ameliorates 2, 4-dinitrofluorobenzene-induced allergic contact dermatitis in BALB/c mice
Li, Yuanyuan; Li, Lin-Feng
关键词Allergic Contact Dermatitis Dinitrofluorobenzene Mouse Qingpeng Ointment Traditional Chinese Medicine
刊名EUROPEAN JOURNAL OF DERMATOLOGY
2013-11-01
DOI10.1684/ejd.2013.2185
23期:6页:803-806
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Dermatology
研究领域[WOS]Dermatology
英文摘要

Background: Qingpeng ointment (QP) is a traditional Chinese medicine which has been used for treatment of eczema in China. However, the mechanisms of its anti-inflammatory activities are not known. Objectives: To assess the anti-inflammatory effects of QP using a mouse model of allergic contact dermatitis, compare the effects with mometasone furoate cream (MF), and to relate the effects to modulation of inflammatory cytokines. Methods: Persistent dermatitis was induced in BALB/c mice using dinitrofluorobenzene. Topical treatment, including the vehicle of QP, 50%, 75%, 100% QP in vehicle, and MF was applied for 14 days. Dermatitis was evaluated macroscopically and microscopically at day 8 and day 15 after treatment. The levels of IL1B, IL2, TNFA, IFNG in both sera and skin tissue were detected with Enzyme-Linked Immunosorbent Assay (ELISA). Results: Significant reductions of skin inflammation in mice skin were observed after treatment with QP and MF, but not with the vehicle of QP. Similar to MF, QP also suppressed the expression of IL1B, IL2, TNFA and IFNG. Conclusion: This study demonstrates that QP inhibits allergic contact dermatitis in mice, similar to MF. QP suppresses the expression of Th1 cytokines in both sera and skin tissue, by which it may exert its anti-inflammatory effects.

语种英语
WOS记录号WOS:000331460000007
资助机构Chinese Association of the Integration of Traditional and Western Medicine
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50610
专题北京大学第三临床医学院_皮肤科
作者单位Peking Univ, Hosp 3, Dept Dermatol, Beijing 100191, Peoples R China
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GB/T 7714
Li, Yuanyuan,Li, Lin-Feng. Topical application of a Chinese medicine, Qingpeng ointment, ameliorates 2, 4-dinitrofluorobenzene-induced allergic contact dermatitis in BALB/c mice[J]. EUROPEAN JOURNAL OF DERMATOLOGY,2013,23(6):803-806.
APA Li, Yuanyuan,&Li, Lin-Feng.(2013).Topical application of a Chinese medicine, Qingpeng ointment, ameliorates 2, 4-dinitrofluorobenzene-induced allergic contact dermatitis in BALB/c mice.EUROPEAN JOURNAL OF DERMATOLOGY,23(6),803-806.
MLA Li, Yuanyuan,et al."Topical application of a Chinese medicine, Qingpeng ointment, ameliorates 2, 4-dinitrofluorobenzene-induced allergic contact dermatitis in BALB/c mice".EUROPEAN JOURNAL OF DERMATOLOGY 23.6(2013):803-806.
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