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Neonatal outcomes after the transfer of vitrified blastocysts: closed versus open vitrification system
Chen, Yuan1,2; Zheng, Xiaoying1,2; Yan, Jie1,2; Qiao, Jie1,2; Liu, Ping1,2
关键词Vitrification Blastocyst Closed Carrier Open Carrier
刊名REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
2013-11-21
DOI10.1186/1477-7827-11-107
11
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Endocrinology & Metabolism ; Reproductive Biology
资助者National Natural Sciences Foundation of China ; National Science Fund for Distinguished Young Scholars ; National Natural Sciences Foundation of China ; National Science Fund for Distinguished Young Scholars
研究领域[WOS]Endocrinology & Metabolism ; Reproductive Biology
关键词[WOS]LIQUID-NITROGEN ; EMBRYO-TRANSFER ; WARMING CYCLES ; CONTAMINATION ; CRYOPRESERVATION ; SURVIVAL ; METAANALYSIS ; OOCYTES
英文摘要

Background: Increasing evidence indicates that closed vitrification has been successfully used in the cryopreservation of human oocytes and embryos. Little information is available regarding the neonatal outcome of closed blastocysts vitrification. The aim of this study was to evaluate the effectiveness and safety of blastocyst vitrification using a high-security closed vitrification system compared with an open vitrification system.

Methods: A total of 332 vitrified-warmed blastocyst transfer cycles between April 2010 and May 2012 were analyzed retrospectively. The post-thaw survival rate, implantation rate, clinical pregnancy rate, live birth rate, and neonatal outcome were recorded.

Results: There were no significant differences between the open vitrification group and the close vitrification group regarding the post-thaw survival rate (98% versus 95.8%), clinical pregnancy rate (47.6% versus 42.2%), implantation rate (42.9% versus 35.6%), and live birth rate (39.8% versus 32.1%). In total, 332 warming cycles produced 131 healthy babies. There were no significant differences in the mean gestational age, the birth weight, and the birth length between the two groups. No adverse neonatal outcomes were observed in the children born after the transfer of closed vitrified blastocysts compared with the transfer of open vitrified blastocysts.

Conclusions: These data suggest that blastocyst vitrification using a closed vitrification device seems safe and effective with results comparable to those obtained through open vitrification.

语种英语
所属项目编号81000234 ; 30825038
资助者National Natural Sciences Foundation of China ; National Science Fund for Distinguished Young Scholars ; National Natural Sciences Foundation of China ; National Science Fund for Distinguished Young Scholars
WOS记录号WOS:000327991500001
引用统计
被引频次:14[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/50621
专题北京大学第三临床医学院_生殖医学中心
作者单位1.Minist Educ, Key Lab Assisted Reprod, Beijing 100191, Peoples R China
2.Peking Univ, Hosp 3, Ctr Reprod Med, Dept Obstet & Gynecol, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Chen, Yuan,Zheng, Xiaoying,Yan, Jie,et al. Neonatal outcomes after the transfer of vitrified blastocysts: closed versus open vitrification system[J]. REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY,2013,11.
APA Chen, Yuan,Zheng, Xiaoying,Yan, Jie,Qiao, Jie,&Liu, Ping.(2013).Neonatal outcomes after the transfer of vitrified blastocysts: closed versus open vitrification system.REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY,11.
MLA Chen, Yuan,et al."Neonatal outcomes after the transfer of vitrified blastocysts: closed versus open vitrification system".REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY 11(2013).
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